Protein Alignment Cpsf100 and INTS9

DIOPT Version :10

• Sequence 1: NP_651658.1
• Gene: Cpsf100 / 43426
• FlyBaseID: FBgn0027873
• Length: 756
• Species: Drosophila melanogaster
• Sequence 2: NP_001349967.1
• Gene: INTS9 / 55756
• HGNCID: 25592
• Length: 676
• Species: Homo sapiens
• Alignment Length: 716
• Identity: 143/716 - (19%)
• Similarity: 260/716 - (36%)
• Gaps: 249/716 - (34%)

  Fly     5 IKLHTISGAMDESPPCYILQIDDVRILLDCGWDEKFDANFI------------------------ 45
            :||:.:||  ..:.||.:|:.....|:||||.|.....||:
Human     1 MKLYCLSG--HPTLPCNVLKFKSTTIMLDCGLDMTSTLNFLPLPLVQSPRLSNLPGWSLKDGNAF 63

  Fly    46 --KELKR---------------------QVHTLDAVLLSHPDAYH-LGALPYLVGKLGLNCPIYA 86
              ||||.                     .:.|:|.:|:|:   || :.||||:....|....:||
Human    64 LDKELKECSGHVFVDSVPEFCLPETELIDLSTVDVILISN---YHCMMALPYITEHTGFTGTVYA 125

  Fly    87 TIPVFKMGQMFMYDLY-----------MSHFNMGDFD------------------LFSLDDVDTA 122
            |.|..::|::.|.:|.           .|.:...|..                  .:::.:|::|
Human   126 TEPTVQIGRLLMEELVNFIERVPKAQSASLWKNKDIQRLLPSPLKDAVEVSTWRRCYTMQEVNSA 190

  Fly   123 FEKITQLKYNQTVSLKDKGYG-ISITPLNAGHMIGGTIWKIVKVGEEDIVYATDFNHKKERHLSG 186
            ..||..:.|:|.:.|    :| :.:|||::|:.:|.:.|.|            ..:::|..::||
Human   191 LSKIQLVGYSQKIEL----FGAVQVTPLSSGYALGSSNWII------------QSHYEKVSYVSG 239

  Fly   187 CELDRLQRPSLLITDAYNAQYQQARRRARDEKLMTNILQ-------------------TVRNNGN 232
                    .|||.|  :.....||..:..|..::|.:.|                   ||||.||
Human   240 --------SSLLTT--HPQPMDQASLKNSDVLVLTGLTQIPTANPDGMVGEFCSNLALTVRNGGN 294

  Fly   233 VLIAVDTAGRVLELAHMLDQLWKNKESGLMAYSLALLNNVSYNVIEFAKSQIEWM-SDKLTKAFE 296
            ||:....:|.:.:|...|.|...:  :||.:..|..::.|:.:.:||::...||: .:|.:|.:
Human   295 VLVPCYPSGVIYDLLECLYQYIDS--AGLSSVPLYFISPVANSSLEFSQIFAEWLCHNKQSKVY- 356

  Fly   297 GARNNPF---------QFKHIQLCH-SLADVYKLPAGPKVVLASTPDLESGFTRDLFVQWASNAN 351
             ....||         :.||....| ..::.::.|.   ||....|.|..|........|..::.
Human   357 -LPEPPFPHAELIQTNKLKHYPSIHGDFSNDFRQPC---VVFTGHPSLRFGDVVHFMELWGKSSL 417

  Fly   352 NSIILT----------------------------------------------------TRTSPG- 363
            |::|.|                                                    |:..|.
Human   418 NTVIFTEPDFSYLEALAPYQPLAMKCIYCPIDTRLNFIQVSKLLKEVQPLHVVCPEQYTQPPPAQ 482

  Fly   364 TLAMELVENCAP-------GKQIELDVRRRVDLEGAELEEYLRTQGEKLNPLIVKPDVEEESSS- 420
            :..|:|:.:|.|       .:.:.|..:||.     |..|.:....:.|.|:.:||.:...:.|
Human   483 SHRMDLMIDCQPPAMSYRRAEVLALPFKRRY-----EKIEIMPELADSLVPMEIKPGISLATVSA 542

  Fly   421 --ESEDDIEMSVITGKHDIVVRPEGR---HHSGFFKSNKR-------HHVMFPYHEEKVKCDEY- 472
              .::|:        ||  :::|..|   ..||  |..||       ..|:.|.....:..:::
Human   543 VLHTKDN--------KH--LLQPPPRPAQPTSG--KKRKRVSDDVPDCKVLKPLLSGSIPVEQFV 595

  Fly   473 ------GEIINLDDYRIA---DATGYEFVPMEEQNKENV---KKEEPGIGAEQQANGGIVDNDVQ 525
                  .::.:|....::   :..|:..:.:|:..|.::   ::.|..|..|:.:...|.|||..
Human   596 QTLEKISQMCSLPSPPLSFLLEQHGFSDIKVEDTAKGHIVLLQEAETLIQIEEDSTHIICDNDEM 660

  Fly   526 L 526
            |
Human   661 L 661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf100	NP_651658.1	CPSF2-like_MBL-fold	7..204	CDD:293851	60/274 (22%)
		Beta-Casp	243..369	CDD:214983	31/189 (16%)
		RMMBL	539..600	CDD:462191
		CPSF100_C	617..753	CDD:463836
INTS9	NP_001349967.1	Int9-like_MBL-fold	1..265	CDD:293852	64/294 (22%)
		Beta-Casp	307..425	CDD:214983	28/124 (23%)