Protein Alignment Cpsf100 and ints11

DIOPT Version :10

• Sequence 1: NP_651658.1
• Gene: Cpsf100 / 43426
• FlyBaseID: FBgn0027873
• Length: 756
• Species: Drosophila melanogaster
• Sequence 2: NP_001018457.1
• Gene: ints11 / 553648
• ZFINID: ZDB-GENE-050522-13
• Length: 598
• Species: Danio rerio
• Alignment Length: 616
• Identity: 132/616 - (21%)
• Similarity: 230/616 - (37%)
• Gaps: 181/616 - (29%)

  Fly     5 IKLHTISGAMDESPPCYILQIDDVRILLDCGW------DEKF-DANFIKELKRQVHTLDAVLLSH 62
            ||:..:....|....|.::.|....|:||||.      |.:| |.::|.:..|....||.|::||
Zfish     4 IKVTPLGAGQDVGRSCILVSIGGKNIMLDCGMHMGFNDDRRFPDFSYITQNGRLTEFLDCVIISH 68

  Fly    63 PDAYHLGALPYLVGKLGLNCPIYATIPVFKMGQMFMYDL-YMSHFNMGDFDLFSLDDVDTAFEKI 126
            ....|.|||||:...:|.:.|||.|.|...:..:.:.|. .::....|:.:.|:...:....:|:
Zfish    69 FHLDHCGALPYMSEMVGYDGPIYMTHPTKAICPILLEDFRKITVDKKGETNFFTSQMIKDCMKKV 133

  Fly   127 TQLKYNQTVSLKDKGYGISITPLNAGHMIGGTIWKIVKVGEEDIVYATDFNHKKERHLSGCELDR 191
            ..|..:|||.:.|:   :.|....|||::|..:.:| |||.|.:||..|:|...:|||....:|:
Zfish   134 VPLNLHQTVQVDDE---LEIKAYYAGHVLGAAMVQI-KVGSESVVYTGDYNMTPDRHLGAAWIDK 194

  Fly   192 LQRPSLLITDAYNAQYQQARRRARDEKLMTNILQTVRNNGNVLIAVDTAGRVLELAHMLDQLWKN 256
            . ||.:||:::..|...:..:|.|:...:..:.:||...|.|||.|...||..||..:|:..|:.
Zfish   195 C-RPDILISESTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWER 258

  Fly   257 KE-SGLMAYSLALLNNVSYNVIEFAKSQIEWMSDKLTKAFEGARNNPFQFKHIQ-LCHSLADVYK 319
            .. ...:.:|..|....::    :.|..|.|.:.|:.|.|  .:.|.|:||||: ...|.||
Zfish   259 MNLKAPIYFSTGLTEKANH----YYKLFITWTNQKIRKTF--VQRNMFEFKHIKAFDRSYAD--- 314

  Fly   320 LPAGPKVVLASTPDLESGFTRDLFVQWASNANNSIILTTRTSPGTLAMELVENCAPGKQIELDVR 384
             ..||.||.|:...|.:|.:..:|.:||.|..|.:|:......||:..::           |:.:
Zfish   315 -NPGPMVVFATPGMLHAGQSLQIFKKWAGNEKNMVIMPGYCVQGTVGHKI-----------LNGQ 367

  Fly   385 RRVDLEGAELEEYLRTQGEKLNPLIVKPDVEEESSSESEDDIEMSVITGKHDIVVRPEGRHHSGF 449
            :::::||
Zfish   368 KKLEMEG---------------------------------------------------------- 374

  Fly   450 FKSNKRHHVMFPYHEEKVKCDEYGEIINLDDYRIADATGYEFVPMEEQNKENVKKEEPGIGAEQQ 514
                                                                             
Zfish   375 ----------------------------------------------------------------- 374

  Fly   515 ANGGIVDNDVQLLEKPTKLISQRKTIEVNAQVQRIDFEGRSDGESMLKILSQLRPRRVIVIHGTA 579
                                  |.|::|..||:.:.|...:|.:.:::::....||.::::||.|
Zfish   375 ----------------------RATLDVKLQVEYMSFSAHADAKGIMQLIRMAEPRNMLLVHGEA 417

  Fly   580 EGTQVVARHCEQNVGARVFTPQKGEIIDVTS 610
            :..:.:....||......|.|..||...:.:
Zfish   418 KKMEFLKDKIEQEFSISCFMPANGETTTIVT 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf100	NP_651658.1	CPSF2-like_MBL-fold	7..204	CDD:293851	61/204 (30%)
		Beta-Casp	243..369	CDD:214983	36/127 (28%)
		RMMBL	539..600	CDD:462191	14/60 (23%)
		CPSF100_C	617..753	CDD:463836
ints11	NP_001018457.1	YSH1	5..416	CDD:440849	123/581 (21%)
		INTS11-like_MBL-fold	6..204	CDD:293849	61/202 (30%)
		HXHXDH motif	68..73		1/4 (25%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q5TA45	470..480