Protein Alignment Cpsf100 and INTS11

DIOPT Version :10

• Sequence 1: NP_651658.1
• Gene: Cpsf100 / 43426
• FlyBaseID: FBgn0027873
• Length: 756
• Species: Drosophila melanogaster
• Sequence 2: XP_011539949.1
• Gene: INTS11 / 54973
• HGNCID: 26052
• Length: 660
• Species: Homo sapiens
• Alignment Length: 622
• Identity: 135/622 - (21%)
• Similarity: 237/622 - (38%)
• Gaps: 182/622 - (29%)

  Fly    15 DESPPCYILQIDDVRILLDCGW------DEKF-DANFIKELKRQVHTLDAVLLSHPDAYHLGALP 72
            |....|.::.|....::||||.      |.:| |.::|.:..|....||.|::||....|.||||
Human    74 DVGRSCILVSIAGKNVMLDCGMHMGFNDDRRFPDFSYITQNGRLTDFLDCVIISHFHLDHCGALP 138

  Fly    73 YLVGKLGLNCPIYATIPVFKMGQMFMYDL-YMSHFNMGDFDLFSLDDVDTAFEKITQLKYNQTVS 136
            |....:|.:.|||.|.|...:..:.:.|. .::....|:.:.|:...:....:|:..:..:|||.
Human   139 YFSEMVGYDGPIYMTHPTQAICPILLEDYRKIAVDKKGEANFFTSQMIKDCMKKVVAVHLHQTVQ 203

  Fly   137 LKDKGYGISITPLNAGHMIGGTIWKIVKVGEEDIVYATDFNHKKERHLSGCELDRLQRPSLLITD 201
            :.|:   :.|....|||::|..:::| |||.|.:||..|:|...:|||....:|:. ||:||||:
Human   204 VDDE---LEIKAYYAGHVLGAAMFQI-KVGSESVVYTGDYNMTPDRHLGAAWIDKC-RPNLLITE 263

  Fly   202 AYNAQYQQARRRARDEKLMTNILQTVRNNGNVLIAVDTAGRVLELAHMLDQLWKNKESGLMAY-S 265
            :..|...:..:|.|:...:..:.:||...|.|||.|...||..||..:|:..|:.....:..| |
Human   264 STYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWERMNLKVPIYFS 328

  Fly   266 LALLNNVSYNVIEFAKSQIEWMSDKLTKAFEGARNNPFQFKHIQ-LCHSLADVYKLPAGPKVVLA 329
            ..|....::    :.|..|.|.:.|:.|.|  .:.|.|:||||: ...:.||    ..||.||.|
Human   329 TGLTEKANH----YYKLFIPWTNQKIRKTF--VQRNMFEFKHIKAFDRAFAD----NPGPMVVFA 383

  Fly   330 STPDLESGFTRDLFVQWASNANNSIILTTRTSPGTLAMELVENCAPGKQIELDVRRRVDLEGAEL 394
            :...|.:|.:..:|.:||.|..|.:|:......||:..::           |..:|::::||
Human   384 TPGMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVGHKI-----------LSGQRKLEMEG--- 434

  Fly   395 EEYLRTQGEKLNPLIVKPDVEEESSSESEDDIEMSVITGKHDIVVRPEGRHHSGFFKSNKRHHVM 459
                                                                             
Human   435 ----------------------------------------------------------------- 434

  Fly   460 FPYHEEKVKCDEYGEIINLDDYRIADATGYEFVPMEEQNKENVKKEEPGIGAEQQANGGIVDNDV 524
                                                                             
Human   435 ----------------------------------------------------------------- 434

  Fly   525 QLLEKPTKLISQRKTIEVNAQVQRIDFEGRSDGESMLKILSQLRPRRVIVIHGTAEGTQVVARHC 589
                        |:.:||..||:.:.|...:|.:.:::::.|..|..|:::||.|:..:.:.:..
Human   435 ------------RQVLEVKMQVEYMSFSAHADAKGIMQLVGQAEPESVLLVHGEAKKMEFLKQKI 487

  Fly   590 EQNVGARVFTPQKGEIIDVTSEIHIYQVRLTEGLVSQ 626
            ||.:....:.|..||.:.:.:...| .|.::.||:.:
Human   488 EQELRVNCYMPANGETVTLPTSPSI-PVGISLGLLKR 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf100	NP_651658.1	CPSF2-like_MBL-fold	7..204	CDD:293851	61/196 (31%)
		Beta-Casp	243..369	CDD:214983	36/127 (28%)
		RMMBL	539..600	CDD:462191	14/60 (23%)
		CPSF100_C	617..753	CDD:463836	3/10 (30%)
INTS11	XP_011539949.1	COG1782	69..506	CDD:441388	131/602 (22%)
		INTS11-like_MBL-fold	70..264	CDD:293849	61/194 (31%)