DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cpsf100 and Cpsf3

DIOPT Version :9

Sequence 1:	NP_651658.1	Gene:	Cpsf100 / 43426	FlyBaseID:	FBgn0027873	Length:	756	Species:	Drosophila melanogaster
Sequence 2:	NP_061283.2	Gene:	Cpsf3 / 54451	MGIID:	1859328	Length:	684	Species:	Mus musculus

Alignment Length:	747	Identity:	171/747 - (22%)
Similarity:	301/747 - (40%)	Gaps:	171/747 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 CYILQIDDVRILLDCGWD---EKFDA----NFIKELKRQVHTLDAVLLSHPDAYHLGALPYLVGK 77
            |.||:....:|:||||..   |..||    :.|...:     :|.:|:||....|.||||:.:.|
Mouse    27 CIILEFKGRKIMLDCGIHPGLEGMDALPYIDLIDPAE-----IDLLLISHFHLDHCGALPWFLQK 86

  Fly    78 L---GLNCPIYATIPVFKMGQMFMYDLYMSHFNMGDFD-LFSLDDVDTAFEKITQLKYNQTVSLK 138
            .   |.....:||..:::    ::...|:...|:...| |::..|::.:.:||..:.:::...:.
Mouse    87 TSFKGRTFMTHATKAIYR----WLLSDYVKVSNISADDMLYTETDLEESMDKIETINFHEVKEVA 147

  Fly   139 DKGYGISITPLNAGHMIGGTIWKIVKVGEEDIVYATDFNHKKERHLSGCELDRLQRPSLLITDAY 203
                ||.....:|||::|..:: ::::....::|..||:.:::|||...|:..: :|.:||.::.
Mouse   148 ----GIKFWCYHAGHVLGAAMF-MIEIAGVKLLYTGDFSRQEDRHLMAAEIPNI-KPDILIIEST 206

  Fly   204 NAQYQQARRRARDEKLMTNILQTVRNNGNVLIAVDTAGRVLELAHMLDQLWKNKESGLMAYSLAL 268
            ...:...:|..|:.:....:...|...|..||.|...||..||..:||:.|:|... |....:..
Mouse   207 YGTHIHEKREEREARFCNTVHDIVNRGGRGLIPVFALGRAQELLLILDEYWQNHPE-LHDIPIYY 270

  Fly   269 LNNVSYNVIEFAKSQIEWMSDKLTKAFEGARNNPFQFKHIQLCHSL---ADVYKLPAGPKVVLAS 330
            .::::...:...::.:..|:||:.|...  .||||.||||....|:   .|:     ||.||:||
Mouse   271 ASSLAKKCMAVYQTYVNAMNDKIRKQIN--INNPFVFKHISNLKSMDHFDDI-----GPSVVMAS 328

  Fly   331 TPDLESGFTRDLFVQWASNANNSIILTTRTSPGTLAMELVENCAPGKQIELDVRRRVDLEGAELE 395
            ...:::|.:|:||..|.::..|.:|:......||||..::                     :|.|
Mouse   329 PGMIQNGLSRELFESWCTDKRNGVIIAGYCVEGTLAKHIM---------------------SEPE 372

  Fly   396 EYLRTQGEKLNPLIVKPDVEEESSSESEDDIEMSVITGKHDIVVRPEGRHHSGFFKSNKRHHVMF 460
            |.....|:|| ||           ..|.|.|..|..|         :.:..|.|.::.|..||:.
Mouse   373 EITTMSGQKL-PL-----------KMSVDYISFSAHT---------DYQQTSEFIRALKPPHVIL 416

  Fly   461 PYHEEKVKCDEYGEIINLDDYRIADATGYEFVPMEEQNKENV---------------------KK 504
            .:.|:       .|:..|....|.:....:.|.:|..|..|.                     ||
Mouse   417 VHGEQ-------NEMARLKAALIREYEDNDEVHIEVHNPRNTEAVTLNFRGEKLAKVMGFLADKK 474

  Fly   505 EEPGIGAEQQANGGIVDNDVQL-------LEKPTKL----ISQRKTIEVNA-------QVQRI-- 549
            .|.|    |:.:|.:|..:...       |...|.|    :.|.:.|....       |:|::
Mouse   475 PEQG----QRVSGILVKRNFNYHILSPCDLSNYTDLAMSTVKQTQAIPYTGPFYLLYYQLQKLTG 535

  Fly   550 DFEGRSDGE----SMLKILSQLRPRRVIVIHGT--------AEGTQVVARHCEQNVGARVFTPQK 602
            |.|.....|    .:.|.::.::...::|:...        |:....|....:.|...|     |
Mouse   536 DVEELEIQEKPALKVFKSITVVQEPGMVVLEWLANPSNDMYADTVTTVILEVQSNPKIR-----K 595

  Fly   603 GEIIDVTS--EIHIYQVRLT--------EGLVSQLQFQKGKDAEV--AWVDGR---LGMRVKAIE 652
            |.:..|:.  |:|:|..||.        |..||.      ||..|  ..|||:   :.:..:|:|
Mouse   596 GAVQKVSKKLEMHVYSKRLEVMLQDIFGEDCVSV------KDDSVLSVTVDGKTANINLETRAVE 654

  Fly   653 APMDVTVEQDASVQEGKTLTLETLADDEIPIH 684
            .  :...|.|.|::|...|..:.|.:...|:|
Mouse   655 C--EEGSEDDESLREMVELAAQRLYEALTPVH 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf100	NP_651658.1	CPSF2-like_MBL-fold	7..204	CDD:293851	48/194 (25%)
		YSH1	19..400	CDD:224157	98/393 (25%)
		Beta-Casp	243..369	CDD:214983	38/128 (30%)
		RMMBL	538..577	CDD:284853	8/51 (16%)
		CPSF100_C	617..753	CDD:290038	21/81 (26%)
Cpsf3	NP_061283.2	CPSF3-like_MBL-fold	12..205	CDD:293850	48/192 (25%)
		YSH1	14..454	CDD:224157	121/498 (24%)
		CPSF73-100_C	479..682	CDD:371691	44/215 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1236
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810