DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cpsf100 and CPSF2

DIOPT Version :9

Sequence 1:	NP_651658.1	Gene:	Cpsf100 / 43426	FlyBaseID:	FBgn0027873	Length:	756	Species:	Drosophila melanogaster
Sequence 2:	NP_001309201.1	Gene:	CPSF2 / 53981	HGNCID:	2325	Length:	782	Species:	Homo sapiens

Alignment Length:	803	Identity:	433/803 - (53%)
Similarity:	560/803 - (69%)	Gaps:	68/803 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTSIIKLHTISGAMDESPPCYILQIDDVRILLDCGWDEKFDANFIKELKRQVHTLDAVLLSHPDA 65
            |||||||.|:||..:||..||:||:|:.|.||||||||.|..:.|..|::.||.:|||||||||.
Human     1 MTSIIKLTTLSGVQEESALCYLLQVDEFRFLLDCGWDEHFSMDIIDSLRKHVHQIDAVLLSHPDP 65

  Fly    66 YHLGALPYLVGKLGLNCPIYATIPVFKMGQMFMYDLYMSHFNMGDFDLFSLDDVDTAFEKITQLK 130
            .|||||||.||||||||.|||||||:|||||||||||.|..|..||.||:|||||.||:||.|||
Human    66 LHLGALPYAVGKLGLNCAIYATIPVYKMGQMFMYDLYQSRHNTEDFTLFTLDDVDAAFDKIQQLK 130

  Fly   131 YNQTVSLKDKGYGISITPLNAGHMIGGTIWKIVKVGEEDIVYATDFNHKKERHLSGCELDRLQRP 195
            ::|.|:||.||:|:|||||.||||||||||||||.|||:||||.|||||:|.||:||.|:.|.||
Human   131 FSQIVNLKGKGHGLSITPLPAGHMIGGTIWKIVKDGEEEIVYAVDFNHKREIHLNGCSLEMLSRP 195

  Fly   196 SLLITDAYNAQYQQARRRARDEKLMTNILQTVRNNGNVLIAVDTAGRVLELAHMLDQLWKNKESG 260
            ||||||::||.|.|.||:.|||:|:||:|:|:|.:|||||||||||||||||.:|||:|:.|::|
Human   196 SLLITDSFNATYVQPRRKQRDEQLLTNVLETLRGDGNVLIAVDTAGRVLELAQLLDQIWRTKDAG 260

  Fly   261 LMAYSLALLNNVSYNVIEFAKSQIEWMSDKLTKAFEGARNNPFQFKHIQLCHSLADVYKLPAGPK 325
            |..|||||||||||||:||:|||:|||||||.:.||..|||||||:|:.|||.|:|:.::|: ||
Human   261 LGVYSLALLNNVSYNVVEFSKSQVEWMSDKLMRCFEDKRNNPFQFRHLSLCHGLSDLARVPS-PK 324

  Fly   326 VVLASTPDLESGFTRDLFVQWASNANNSIILTTRTSPGTLAMELVENCAPGKQI-ELDVRRRVDL 389
            |||||.||||.||:||||:||..:..||||||.||:|||||..|::|  |.::| |:::|:||.|
Human   325 VVLASQPDLECGFSRDLFIQWCQDPKNSIILTYRTTPGTLARFLIDN--PSEKITEIELRKRVKL 387

  Fly   390 EGAELEEYLRTQGEKLNPLIVK-------PDVEEESSSESEDDIEM-SVITGKHDIVVRPEGRHH 446
            ||.||||||  :.|||.....|       .|::....|:.|:||:. |....|||::::.||...
Human   388 EGKELEEYL--EKEKLKKEAAKKLEQSKEADIDSSDESDIEEDIDQPSAHKTKHDLMMKGEGSRK 450

  Fly   447 SGFFKSNKRHHVMFPYHEEKVKCDEYGEIINLDDYRIADATGYEFVPMEEQNKENVKKEEPGIGA 511
            ..|||..|:.:.|||..||::|.|||||||..:|:         .||..:..:|...|.|.|:
Human   451 GSFFKQAKKSYPMFPAPEERIKWDEYGEIIKPEDF---------LVPELQATEEEKSKLESGL-- 504

  Fly   512 EQQANGGIVDNDVQLLEKPTKLISQRKTIEVNAQVQRIDFEGRSDGESMLKILSQLRPRRVIVIH 576
                ..|....|..|.:.|||.||..::||:.|:|..||:||||||:|:.||::|::||::|::|
Human   505 ----TNGDEPMDQDLSDVPTKCISTTESIEIKARVTYIDYEGRSDGDSIKKIINQMKPRQLIIVH 565

  Fly   577 GTAEGTQVVARHCEQNVG--ARVFTPQKGEIIDVTSEIHIYQVRLTEGLVSQLQFQKGKDAEVAW 639
            |..|.:|.:|..|....|  .:|:.|:..|.:|.|||.|||||||.:.|||.|||.|.||||:||
Human   566 GPPEASQDLAECCRAFGGKDIKVYMPKLHETVDATSETHIYQVRLKDSLVSSLQFCKAKDAELAW 630

  Fly   640 VDGRLGMRVK----------------------AIEAPMDVTV-------------EQDASVQEGK 669
            :||.|.|||.                      .:|||.|.:|             ::..:.:|.:
Human   631 IDGVLDMRVSKVDTGVILEEGELKDDGEDSEMQVEAPSDSSVIAQQKAMKSLFGDDEKETGEESE 695

  Fly   670 TL-TLETLADDEIPIHNSVLINELKLSDFKQTLMRNNINSEFSGGVLWCSNGTLALRRVDAGKVA 733
            .: |||.|...|:|.|.||.:||.:||||||.|:|..|.:||.||||.|:| .:|:||.:.|::.
Human   696 IIPTLEPLPPHEVPGHQSVFMNEPRLSDFKQVLLREGIQAEFVGGVLVCNN-QVAVRRTETGRIG 759

  Fly   734 MEGCLSEEYYKIRELLYEQYAIV 756
            :||||.:::|:||:|||||||||
Human   760 LEGCLCQDFYRIRDLLYEQYAIV 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf100	NP_651658.1	CPSF2-like_MBL-fold	7..204	CDD:293851	138/196 (70%)
		YSH1	19..400	CDD:224157	261/381 (69%)
		Beta-Casp	243..369	CDD:214983	85/125 (68%)
		RMMBL	538..577	CDD:284853	19/38 (50%)
		CPSF100_C	617..753	CDD:290038	71/171 (42%)
CPSF2	NP_001309201.1	CPSF2-like_MBL-fold	7..204	CDD:293851	138/196 (70%)
		Beta-Casp	243..368	CDD:214983	85/125 (68%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	407..449		12/41 (29%)
		RMMBL	529..591	CDD:400070	27/61 (44%)
		CPSF100_C	608..779	CDD:404222	71/171 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147385
Domainoid	1	1.000	266	1.000	Domainoid score	I1897
eggNOG	1	0.900	-	-		E1_COG1236
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6460
Inparanoid	1	1.050	821	1.000	Inparanoid score	I472
Isobase	1	0.950	-	0	Normalized mean entropy	S2127
OMA	1	1.010	-	-		QHG53972
OrthoDB	1	1.010	-	-		D129179at33208
OrthoFinder	1	1.000	-	-		FOG0005213
OrthoInspector	1	1.000	-	-		oto89362
orthoMCL	1	0.900	-	-		OOG6_103283
Panther	1	1.100	-	-	LDO	PTHR45922
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R191
SonicParanoid	1	1.000	-	-		X3727
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750