DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cpsf100 and CPSF3

DIOPT Version :9

Sequence 1:	NP_651658.1	Gene:	Cpsf100 / 43426	FlyBaseID:	FBgn0027873	Length:	756	Species:	Drosophila melanogaster
Sequence 2:	NP_001308765.1	Gene:	CPSF3 / 51692	HGNCID:	2326	Length:	688	Species:	Homo sapiens

Alignment Length:	747	Identity:	171/747 - (22%)
Similarity:	300/747 - (40%)	Gaps:	171/747 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 CYILQIDDVRILLDCGWD---EKFDA----NFIKELKRQVHTLDAVLLSHPDAYHLGALPYLVGK 77
            |.||:....:|:||||..   |..||    :.|...:     :|.:|:||....|.||||:.:.|
Human    31 CIILEFKGRKIMLDCGIHPGLEGMDALPYIDLIDPAE-----IDLLLISHFHLDHCGALPWFLQK 90

  Fly    78 L---GLNCPIYATIPVFKMGQMFMYDLYMSHFNMGDFD-LFSLDDVDTAFEKITQLKYNQTVSLK 138
            .   |.....:||..:::    ::...|:...|:...| |::..|::.:.:||..:.:::...:.
Human    91 TSFKGRTFMTHATKAIYR----WLLSDYVKVSNISADDMLYTETDLEESMDKIETINFHEVKEVA 151

  Fly   139 DKGYGISITPLNAGHMIGGTIWKIVKVGEEDIVYATDFNHKKERHLSGCELDRLQRPSLLITDAY 203
                ||.....:|||::|..:: ::::....::|..||:.:::|||...|:..: :|.:||.::.
Human   152 ----GIKFWCYHAGHVLGAAMF-MIEIAGVKLLYTGDFSRQEDRHLMAAEIPNI-KPDILIIEST 210

  Fly   204 NAQYQQARRRARDEKLMTNILQTVRNNGNVLIAVDTAGRVLELAHMLDQLWKNKESGLMAYSLAL 268
            ...:...:|..|:.:....:...|...|..||.|...||..||..:||:.|:|... |....:..
Human   211 YGTHIHEKREEREARFCNTVHDIVNRGGRGLIPVFALGRAQELLLILDEYWQNHPE-LHDIPIYY 274

  Fly   269 LNNVSYNVIEFAKSQIEWMSDKLTKAFEGARNNPFQFKHIQLCHSL---ADVYKLPAGPKVVLAS 330
            .::::...:...::.:..|:||:.|...  .||||.||||....|:   .|:     ||.||:||
Human   275 ASSLAKKCMAVYQTYVNAMNDKIRKQIN--INNPFVFKHISNLKSMDHFDDI-----GPSVVMAS 332

  Fly   331 TPDLESGFTRDLFVQWASNANNSIILTTRTSPGTLAMELVENCAPGKQIELDVRRRVDLEGAELE 395
            ...::||.:|:||..|.::..|.:|:......||||..::                     :|.|
Human   333 PGMMQSGLSRELFESWCTDKRNGVIIAGYCVEGTLAKHIM---------------------SEPE 376

  Fly   396 EYLRTQGEKLNPLIVKPDVEEESSSESEDDIEMSVITGKHDIVVRPEGRHHSGFFKSNKRHHVMF 460
            |.....|:|| ||           ..|.|.|..|..|         :.:..|.|.::.|..||:.
Human   377 EITTMSGQKL-PL-----------KMSVDYISFSAHT---------DYQQTSEFIRALKPPHVIL 420

  Fly   461 PYHEEKVKCDEYGEIINLDDYRIADATGYEFVPMEEQNKENV---------------------KK 504
            .:.|:       .|:..|....|.:....:.|.:|..|..|.                     ||
Human   421 VHGEQ-------NEMARLKAALIREYEDNDEVHIEVHNPRNTEAVTLNFRGEKLAKVMGFLADKK 478

  Fly   505 EEPGIGAEQQANGGIVDNDVQL-------LEKPTKL----ISQRKTIEVNA-------QVQRI-- 549
            .|.|    |:.:|.:|..:...       |...|.|    :.|.:.|....       |:|::
Human   479 PEQG----QRVSGILVKRNFNYHILSPCDLSNYTDLAMSTVKQTQAIPYTGPFNLLCYQLQKLTG 539

  Fly   550 DFEGRSDGE----SMLKILSQLRPRRVIVIHGT--------AEGTQVVARHCEQNVGARVFTPQK 602
            |.|.....|    .:.|.::.::...::|:...        |:....|....:.|...|     |
Human   540 DVEELEIQEKPALKVFKNITVIQEPGMVVLEWLANPSNDMYADTVTTVILEVQSNPKIR-----K 599

  Fly   603 GEIIDVTS--EIHIYQVRLT--------EGLVSQLQFQKGKDAEV--AWVDGR---LGMRVKAIE 652
            |.:..|:.  |:|:|..||.        |..||.      ||..:  ..|||:   |.:..:.:|
Human   600 GAVQKVSKKLEMHVYSKRLEIMLQDIFGEDCVSV------KDDSILSVTVDGKTANLNLETRTVE 658

  Fly   653 APMDVTVEQDASVQEGKTLTLETLADDEIPIH 684
            .  :...|.|.|::|...|..:.|.:...|:|
Human   659 C--EEGSEDDESLREMVELAAQRLYEALTPVH 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf100	NP_651658.1	CPSF2-like_MBL-fold	7..204	CDD:293851	48/194 (25%)
		YSH1	19..400	CDD:224157	99/393 (25%)
		Beta-Casp	243..369	CDD:214983	39/128 (30%)
		RMMBL	538..577	CDD:284853	8/51 (16%)
		CPSF100_C	617..753	CDD:290038	20/81 (25%)
CPSF3	NP_001308765.1	YSH1	22..458	CDD:224157	122/498 (24%)
		CPSF3-like_MBL-fold	22..209	CDD:293850	48/192 (25%)
		Beta-Casp	250..371	CDD:214983	39/128 (30%)
		RMMBL	384..424	CDD:284853	14/60 (23%)
		CPSF73-100_C	481..687	CDD:215023	44/222 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1236
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810