DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cpsf100 and Snm1

DIOPT Version :9

Sequence 1:	NP_651658.1	Gene:	Cpsf100 / 43426	FlyBaseID:	FBgn0027873	Length:	756	Species:	Drosophila melanogaster
Sequence 2:	NP_649548.1	Gene:	Snm1 / 40669	FlyBaseID:	FBgn0037338	Length:	763	Species:	Drosophila melanogaster

Alignment Length:	527	Identity:	100/527 - (18%)
Similarity:	167/527 - (31%)	Gaps:	197/527 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 ELKRQVHTLDAVLLS-----HPDAYHLGALPYLVGK---LGLN--------------CPIYATIP 89
            |.|....:||.|.:|     .|......:.|..:.|   ||.|              ||.|..:.
  Fly   207 EAKLSNSSLDLVEISPGPNKSPTNNFYRSSPAAITKESPLGKNSKKGTVRKQRKPKPCPPYKVVE 271

  Fly    90 VFKMGQMFMYD------------LYMSHFNMGDF----------------------DLFSLDDVD 120
                |..|..|            .:::||:...:                      ....||:.
  Fly   272 ----GTSFCVDGFQFGEIEGVTHYFLTHFHADHYIGLTKKFCHPLYVSPISARLVRTFIKLDET- 331

  Fly   121 TAFEKITQLKYNQTVSLKDKGYGISITPLNAGHMIGGTIWKIVKVGEEDIVYATDF--------- 176
                .|.::..:||:.:.    |:.:|.|.|.|..|..::.......|.|::..||
  Fly   332 ----HIHEIDVDQTLDVD----GVQVTALEANHCPGALMFFFKLSSGECILHTGDFRASADMESL 388

  Fly   177 ----NHKKERHLSGCELDRLQRPSLLITDAYNAQYQ-QARRRARDEKLMTNILQTVRNNGNVLIA 236
                ||.        .:|.|...:..:...|:..:| ::..||.|  |:...|:  :|....::.
  Fly   389 PIFWNHS--------NIDLLYLDTTYMNKNYDFCHQSESVDRAVD--LVRAFLE--KNAAKRILI 441

  Fly   237 V-----------------------------DTAGRVLELAHMLDQLWKNKESGLMAYSLALLNNV 272
            |                             .||.|.|.... ||.:.....||...:.:| :..:
  Fly   442 VCGSYVIGKEKIWLALAKEFTMRVWTESNRSTAVRCLNWPD-LDSVLTEDRSGANLHVIA-MGKI 504

  Fly   273 SY-NVIEF---AKSQIE---------WMSDKLTKAFEGARNNPFQFKHIQLCHSLADVYK----- 319
            || :::::   .:.|.:         |  :|.:|...|.|.:....::.:  ||   .||
  Fly   505 SYPSLVDYFTEFEDQYDMLLGIRPSGW--EKNSKPSYGKRISTIGIEYSE--HS---SYKELERF 562

  Fly   320 ---LPAGPKVVLASTPDLESGFTRDLFV------QWASNANNSIILTTRTSPGTLAMELVENCAP 375
               |.  ||.|:::.|     ..|||:|      :|......:.:|.|...|...........|.
  Fly   563 VRFLK--PKRVISTVP-----VGRDLYVTGEVPIRWYKYEGRASMLRTGFQPSISTFLATPKRAF 620

  Fly   376 GKQIELDVRRRVDLEGAELEEYLRTQGEKLNPLIVKPDVEEESSSESE---DDIEMSVITGKHDI 437
            .|            ..|:.|.:       |:|      |:|.:|..||   ||...||:...|..
  Fly   621 AK------------FSADTEMF-------LSP------VDENASKGSEDKKDDDRESVVPTNHVT 660

  Fly   438 VV--RPE 442
            ::  .||
  Fly   661 IISDTPE 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf100	NP_651658.1	CPSF2-like_MBL-fold	7..204	CDD:293851	39/225 (17%)
		YSH1	19..400	CDD:224157	86/478 (18%)
		Beta-Casp	243..369	CDD:214983	31/152 (20%)
		RMMBL	538..577	CDD:284853
		CPSF100_C	617..753	CDD:290038
Snm1	NP_649548.1	SNM1A-1C-like_MBL-fold	252..408	CDD:293831	27/176 (15%)
Snm1	NP_649548.1	DRMBL	481..578	CDD:284854	22/112 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1236
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900