DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cpsf100 and dclre1a

DIOPT Version :9

Sequence 1:	NP_651658.1	Gene:	Cpsf100 / 43426	FlyBaseID:	FBgn0027873	Length:	756	Species:	Drosophila melanogaster
Sequence 2:	NP_001018385.4	Gene:	dclre1a / 324964	ZFINID:	ZDB-GENE-050522-124	Length:	926	Species:	Danio rerio

Alignment Length:	828	Identity:	151/828 - (18%)
Similarity:	255/828 - (30%)	Gaps:	281/828 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 LKYNQTVSLKDKGYGISITPLNAGHMIGGTIWKIVKVGEEDIVYATDFNHKKERHL------SGC 187
            ||.|:..|.|.:|....:|....    ..|:.|.||..|:.    ||.:|:...:.      ||.
Zfish    16 LKKNKKRSCKSQGSREHVTKRKK----ESTVQKTVKSAEKH----TDLDHQIGSNAPNNTVNSGS 72

  Fly   188 E------LDRLQRPSLLITDAYNAQYQQARRRARDEKLMTNILQTVRNNGNVLIAVDTAGRVLEL 246
            |      :.|         |..||..|..|......::..:||.......:|...:|||.
Zfish    73 EDVNHGTVSR---------DVPNADSQSGRGFCPVCQMPFSILVVQSQQWHVAECLDTAA----- 123

  Fly   247 AHMLDQLWKNKESGLMAYSLALLNNVSYNVIEFAKSQ-----IEWMSDKLTKAFEGARNNPFQFK 306
                |.. |....||...|....:...||..:.|:|:     ::.:||....:.....:...:..
Zfish   124 ----DNC-KECPDGLQCMSTIPNHYKRYNHSQLAQSRAQNDSVQAISDFSLNSVNNGASTSVKES 183

  Fly   307 HIQLCHSLADVYKLPAGPKVVLASTPD-------LESGFTRDLFVQ--WASNANNS--------- 353
            .:....:::......:.|...|..||.       |.|..|.|:..:  |:.:...|
Zfish   184 SVDSAVNVSASSSQSSSPGDRLKGTPTKSNALLLLRSPNTEDIKKKKGWSPSVKRSQSQISSQEA 248

  Fly   354 ------------IILTTRTSPGTLAMELVE--------NCAPGKQI-ELDVRRRVDLEGAELEEY 397
                        :....:|.|..:..||.|        :|:|..:: |:|...||:....:...|
Zfish   249 KAKISAPGEVRCVDSAVQTQPNEVKKELFECKDDDDYISCSPLSELPEVDEEHRVEKSNNDRHFY 313

  Fly   398 ---LRTQGEKLNPLIVKPDVEEESSSESEDDIEMSVI---------------TGKHDIVVRPEGR 444
               |:...:.||..           |:.:||:...||               ..|....:.||..
Zfish   314 STALQEDDDSLNLF-----------SDEDDDLFFDVIDQYEEHGPDKSSLDTCEKQQTSLAPESH 367

  Fly   445 -----------HHSGFFKSNKRHHVMFPYHEEKVKCDEYGEIINLDDYRIADATGYEFVPMEEQN 498
                       ||.....::....:..|   :.:..:...:.|:...:..:..:.:|.|...:.|
Zfish   368 LTASSSTGVSFHHCSTNNNSSNSQLQSP---QSLVLEHLRDRISTPTHVKSLTSSFEEVNFTQTN 429

  Fly   499 KENVKKE----------------EPGIGAEQQANGGI-----------VDNDVQLLEKPTKLISQ 536
            :|:...:                :.|....:|.:.|:           ...:|:.|.:...|...
Zfish   430 QESFSNQADLSATQSMAPRRTQIKAGPSGLKQTDIGVFFGLKPLHEKKAGKEVKPLVREADLQKS 494

  Fly   537 RKTIEVNAQVQRIDFEGR--------SDG-------ESMLKILSQLRPRRVIVIHGTAEGTQ--- 583
            |:.....||.:....:||        |:|       |..:.:.:|...:|    .|.|||.:
Zfish   495 RRVRVSEAQGEDGKRQGRWRGKSKAPSEGSGVSPAVEDSVALPTQTEGKR----GGRAEGRKRWN 555

  Fly   584 ---------VVARHCE-----QNVGARVFTPQKGEIIDVT------------------SEIHIYQ 616
                     ...:.|.     ...|..|...|.|.:..||                  |.:.||.
Zfish   556 RGKATDGDPKEPKRCPFYKKIPGTGFAVDAFQYGVVEGVTAYFLTHFHSDHYGGLKKDSAVPIYC 620

  Fly   617 VRLTEGLV-SQLQFQKGKDAEVAWVDGRLGMRVKAIEAPMDVTVEQDASVQEGKTLTLETLADDE 680
            .::|..|| |:|:.    |.:...|   |.|..:.|...:.||: .||:...|..:.|..|.|.:
Zfish   621 NKVTSNLVKSKLKV----DEQYIHV---LPMNTECIVQGVKVTL-LDANHCPGAAMLLFVLPDGQ 677

  Fly   681 IPIHNSVLINELKLSDFK----------------QTLMRNN-------------------INSEF 710
            ..:|.         .||:                |||..:.                   :|:.|
Zfish   678 TVLHT---------GDFRADPSMERYPELQGLRIQTLYLDTTYCSPEYTFPTQQEVVTFAVNTAF 733

  Fly   711 SGGVL------WCSNGT---------LALRRVDAGKVAMEGCLSEEYY 743
            ....|      .|  ||         ||:..|.:.||    |||::.|
Zfish   734 ERVTLNPRTLVVC--GTYSVGKEKVFLAVSEVLSSKV----CLSKDKY 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf100	NP_651658.1	CPSF2-like_MBL-fold	7..204	CDD:293851	20/86 (23%)
		YSH1	19..400	CDD:224157	64/329 (19%)
		Beta-Casp	243..369	CDD:214983	23/160 (14%)
		RMMBL	538..577	CDD:284853	9/53 (17%)
		CPSF100_C	617..753	CDD:290038	39/178 (22%)
dclre1a	NP_001018385.4	SNM1A-like_MBL-fold	558..714	CDD:293856	34/172 (20%)
dclre1a	NP_001018385.4	DRMBL	785..888	CDD:284854
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1236
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900