DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cpsf100 and cpsf3

DIOPT Version :9

Sequence 1:	NP_651658.1	Gene:	Cpsf100 / 43426	FlyBaseID:	FBgn0027873	Length:	756	Species:	Drosophila melanogaster
Sequence 2:	NP_001003836.1	Gene:	cpsf3 / 324554	ZFINID:	ZDB-GENE-030131-3275	Length:	690	Species:	Danio rerio

Alignment Length:	750	Identity:	166/750 - (22%)
Similarity:	297/750 - (39%)	Gaps:	180/750 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 CYILQIDDVRILLDCGWD---EKFDA----NFIKELKRQVHTLDAVLLSHPDAYHLGALPYLVGK 77
            |.||:....:|::|||..   |..||    :.|...:     :|.:|:||....|.||||:.:.|
Zfish    34 CIILEFKGRKIMVDCGIHPGLEGMDALPYIDLIDPAE-----IDLLLISHFHLDHCGALPWFLQK 93

  Fly    78 L---GLNCPIYATIPVFKMGQMFMYDLYMSHFNMGDFD-LFSLDDVDTAFEKITQLKYNQTVSLK 138
            .   |.....:||..:::    ::...|:...|:...| |::..|::.:.:||..:.:::...:.
Zfish    94 TSFKGRTFMTHATKAIYR----WLLSDYVKVSNISADDMLYTETDLEESMDKIETINFHEVKEVA 154

  Fly   139 DKGYGISITPLNAGHMIGGTIWKIVKVGEEDIVYATDFNHKKERHLSGCELDRLQRPSLLITDAY 203
                ||.....:|||::|..:: ::::....::|..||:.:::|||...|:..: :|.:|||::.
Zfish   155 ----GIKFWCYHAGHVLGAAMF-MIEIAGVKLLYTGDFSRQEDRHLMAAEIPSV-KPDILITEST 213

  Fly   204 NAQYQQARRRARDEKLMTNILQTVRNNGNVLIAVDTAGRVLELAHMLDQLWKNKESGLMAYSLAL 268
            ...:...:|..|:.:....:...|...|..||.|...||..||..:||:.|:|... |....:..
Zfish   214 YGTHIHEKREEREARFCNTVHDIVNREGRCLIPVFALGRAQELLLILDEYWQNHPE-LHDIPIYY 277

  Fly   269 LNNVSYNVIEFAKSQIEWMSDKLTKAFEGARNNPFQFKHIQLCHSL---ADVYKLPAGPKVVLAS 330
            .::::...:...::.:..|:||:.||..  .||||.||||....|:   .|:     ||.||:||
Zfish   278 ASSLAKKCMAVYQTYVNAMNDKIRKAIN--INNPFVFKHISNLKSMDHFDDI-----GPSVVMAS 335

  Fly   331 TPDLESGFTRDLFVQWASNANNSIILTTRTSPGTLAMELVENCAPGKQIELDVRRRVDLEGAELE 395
            ...::||.:|:||..|.::..|.:|:......||||..::                     :|.|
Zfish   336 PGMMQSGLSRELFESWCTDKRNGVIIAGYCVEGTLAKHIM---------------------SEPE 379

  Fly   396 EYLRTQGEKLNPLIVKPDVEEESSSESEDDIEMSVITGKHDIVVRPEGRHHSGFFKSNKRHHVMF 460
            |.....|:|| ||           ..|.|.|..|..|         :.:..|.|.::.|..||:.
Zfish   380 EITTMSGQKL-PL-----------KMSVDYISFSAHT---------DYQQTSEFIRALKPPHVIL 423

  Fly   461 PYHEEKVKCDEYGEIINLDDYRIADATGYEFVPMEEQNKENVKKEEPGIGAEQQAN--GGIVDND 523
            .:.|:       .|:..|....|.:....:.|.:|..|..|.:........|:.|.  |.:.|..
Zfish   424 VHGEQ-------NEMARLKAALIREYEDNDEVHIEVHNPRNTEAVTLNFRGEKLAKVMGSLADKK 481

  Fly   524 VQLLEKPTKLISQRK-----------------TIEVNAQVQRIDFEGRSDGESMLKILSQLRP-- 569
            ....::.:.::.::.                 .:....|.|.|.|.|     ....:|||||.
Zfish   482 CSQGQRVSGILVKKNFSYHILSPSDLSNYTDLAMSTVKQTQAIPFTG-----PFPLLLSQLRHLT 541

  Fly   570 -----------------RRVIVIHGT----------------AEGTQVVARHCEQNVGA-RVFTP 600
                             ..:.|||..                |:....|....:.|..| :...|
Zfish   542 GDVEEIEMSEKSTVKVFNSITVIHENNLVVLEWFANPLNDMYADAVTTVVLEVQSNPKAQKALQP 606

  Fly   601 QKGEIIDVTSEIHIYQVRLTEGLVSQLQFQ----------KGK-------DAEVAWVDGRLGMRV 648
            |:.::     :::::|.||.:      .||          |.|       |.:.|::|  |..|.
Zfish   607 QEKKV-----DVNVFQNRLLK------MFQDMFGEECVDFKDKNCLAVNVDEKTAFID--LETRT 658

  Fly   649 KAIEAPMDVTVEQDASVQEGKTLTLETLADDEIPI 683
            ...|.|.    .:|.|::|...|.::.|.:...|:
Zfish   659 VEYEEPN----PEDDSLREMLELAVQRLYEAINPV 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf100	NP_651658.1	CPSF2-like_MBL-fold	7..204	CDD:293851	48/194 (25%)
		YSH1	19..400	CDD:224157	100/393 (25%)
		Beta-Casp	243..369	CDD:214983	40/128 (31%)
		RMMBL	538..577	CDD:284853	12/74 (16%)
		CPSF100_C	617..753	CDD:290038	19/83 (23%)
cpsf3	NP_001003836.1	CPSF3-like_MBL-fold	19..212	CDD:293850	48/192 (25%)
		YSH1	21..461	CDD:224157	123/498 (25%)
		Beta-Casp	253..374	CDD:214983	40/128 (31%)
		RMMBL	387..427	CDD:284853	14/60 (23%)
		CPSF73-100_C	485..638	CDD:288554	25/168 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1236
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810