Protein Alignment Cpsf100 and Cpsf3

DIOPT Version :10

• Sequence 1: NP_651658.1
• Gene: Cpsf100 / 43426
• FlyBaseID: FBgn0027873
• Length: 756
• Species: Drosophila melanogaster
• Sequence 2: NP_001025201.1
• Gene: Cpsf3 / 298916
• RGDID: 1305767
• Length: 685
• Species: Rattus norvegicus
• Alignment Length: 748
• Identity: 171/748 - (22%)
• Similarity: 301/748 - (40%)
• Gaps: 172/748 - (22%)

  Fly    20 CYILQIDDVRILLDCGWD---EKFDA----NFIKELKRQVHTLDAVLLSHPDAYHLGALPYLVGK 77
            |.||:....:|:||||..   |..||    :.|...:     :|.:|:||....|.||||:.:.|
  Rat    27 CIILEFKGRKIMLDCGIHPGLEGMDALPYIDLIDPAE-----IDLLLISHFHLDHCGALPWFLQK 86

  Fly    78 L---GLNCPIYATIPVFKMGQMFMYDLYMSHFNMGDFD-LFSLDDVDTAFEKITQLKYNQTVSLK 138
            .   |.....:||..:::    ::...|:...|:...| |::..|::.:.:||..:.:::...:.
  Rat    87 TSFKGRTFMTHATKAIYR----WLLSDYVKVSNISADDMLYTETDLEESMDKIETINFHEVKEVA 147

  Fly   139 DKGYGISITPLNAGHMIGGTIWKIVKVGEEDIVYATDFNHKKERHLSGCELDRLQRPSLLITDAY 203
                ||.....:|||::|..:: ::::....::|..||:.:::|||...|:..: :|.:||.::.
  Rat   148 ----GIKFWCYHAGHVLGAAMF-MIEIAGMKLLYTGDFSRQEDRHLMAAEIPNI-KPDILIIEST 206

  Fly   204 NAQYQQARRRARDEKLMTNILQTVRNNGNVLIAVDTAGRVLELAHMLDQLWKNKESGLMAYSLAL 268
            ...:...:|..|:.:....:...|...|..||.|...||..||..:||:.|:|... |....:..
  Rat   207 YGTHIHEKREEREARFCNTVHDIVNRGGRGLIPVFALGRAQELLLILDEYWQNHPE-LHDIPIYY 270

  Fly   269 LNNVSYNVIEFAKSQIEWMSDKLTKAFEGARNNPFQFKHIQLCHSL---ADVYKLPAGPKVVLAS 330
            .::::...:...::.:..|:||:.|...  .||||.||||....|:   .|:     ||.||:||
  Rat   271 ASSLAKKCMAVYQTYVNAMNDKIRKQIN--INNPFVFKHISNLKSMDHFDDI-----GPSVVMAS 328

  Fly   331 TPDLESGFTRDLFVQWASNANNSIILTTRTSPGTLAMELVENCAPGKQIELDVRRRVDLEGAELE 395
            ...:::|.:|:||..|.::..|.:|:......||||..::                     :|.|
  Rat   329 PGMIQNGLSRELFESWCTDKRNGVIIAGYCVEGTLAKHIM---------------------SEPE 372

  Fly   396 EYLRTQGEKLNPLIVKPDVEEESSSESEDDIEMSVITGKHDIVVRPEGRHHSGFFKSNKRHHVMF 460
            |.....|:|| ||           ..|.|.|..|..|         :.:..|.|.::.|..||:.
  Rat   373 EITTMSGQKL-PL-----------KMSVDYISFSAHT---------DYQQTSEFIRALKPPHVIL 416

  Fly   461 PYHEEKVKCDEYGEIINLDDYRIADATGYEFVPMEEQNKENV---------------------KK 504
            .:.|:       .|:..|....|.:....:.|.:|..|..|.                     ||
  Rat   417 VHGEQ-------NEMARLKAALIREYEDNDEVHIEVHNPRNTEAVTLNFRGEKLAKVMGFLADKK 474

  Fly   505 EEPGIGAEQQANGGIVDNDVQL-------LEKPTKL----ISQRKTIEVNA-------QVQRI-- 549
            .|.|    |:.:|.:|..:...       |...|.|    :.|.:.|....       |:|::
  Rat   475 PEQG----QRVSGILVKRNFNYHILSPCDLSNYTDLAMSTVKQTQAIPYTGPFYLLYYQLQKLTG 535

  Fly   550 DFEGRSDGE----SMLKILSQLRPRRVIVIHGT--------AEGTQVVARHCEQNVGARVFTPQK 602
            |.|.....|    .:.|.::.::...::|:...        |:....|....:.|...|     |
  Rat   536 DVEELEIQEKPALKVFKSITVVQEPGMVVLEWLANPSNDMYADTVTTVILEVQSNPKIR-----K 595

  Fly   603 GEIIDVTS--EIHIYQVRLT--------EGLVSQLQFQKGKDAEV--AWVDGR---LGMRVKAIE 652
            |.:..|:.  |:|:|..||.        |..||.      ||..|  ..|||:   :.:..:|:|
  Rat   596 GAVQKVSKKLEMHVYSKRLEVMLQDIFGEDCVSV------KDDSVLSVTVDGKTANINLETRAVE 654

  Fly   653 APMDVTVEQDASVQEGKTLTLETLADD-EIPIH 684
            .  :...|.|.|::|...|..:.|.:. ..|:|
  Rat   655 C--EEGSEDDESLREMVELAAQRLYEALTPPVH 685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf100	NP_651658.1	CPSF2-like_MBL-fold	7..204	CDD:293851	48/194 (25%)
		Beta-Casp	243..369	CDD:214983	38/128 (30%)
		RMMBL	539..600	CDD:462191	12/81 (15%)
		CPSF100_C	617..753	CDD:463836	21/82 (26%)
Cpsf3	NP_001025201.1	CPSF3-like_MBL-fold	12..205	CDD:293850	48/192 (25%)
		YSH1	14..421	CDD:440849	113/458 (25%)
		CPSF73-100_C	479..682	CDD:463330	44/215 (20%)