DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cpsf100 and cft2

DIOPT Version :9

Sequence 1:	NP_651658.1	Gene:	Cpsf100 / 43426	FlyBaseID:	FBgn0027873	Length:	756	Species:	Drosophila melanogaster
Sequence 2:	NP_595448.1	Gene:	cft2 / 2539954	PomBaseID:	SPBC1709.15c	Length:	797	Species:	Schizosaccharomyces pombe

Alignment Length:	812	Identity:	245/812 - (30%)
Similarity:	405/812 - (49%)	Gaps:	110/812 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LQIDDVRILLDCGWDEKFDANFIKELKRQVHTLDAVLLSHPDAYHLGALPYLVGKLG-LNCPIYA 86
            :::|.:.|.:|.|.|:......:.|..      |.:||||.|..|:|.|.|...|.. .|..|||
pombe    18 IELDGIHIYIDPGSDDSLKHPEVPEQP------DLILLSHSDLAHIGGLVYAYYKYDWKNAYIYA 76

  Fly    87 TIPVFKMGQMFMYDLYMSHFNMGDFDLFSLDDVDTAFEKITQLKYNQTVSLKDKGYGISITPLNA 151
            |:|...||:|.|.|...|:: :.|   .|..|||..|:.|..|:|.|...|..|..|::||..||
pombe    77 TLPTINMGRMTMLDAIKSNY-ISD---MSKADVDAVFDSIIPLRYQQPTLLLGKCSGLTITAYNA 137

  Fly   152 GHMIGGTIWKIVKVGEEDIVYATDFNHKKERHLSGCE-------LDRLQRPSLLITDAYNAQYQQ 209
            ||.:|||:|.::| ..|.::||.|:||.|::||:|..       |:.|.||:.|||||.|:....
pombe   138 GHTLGGTLWSLIK-ESESVLYAVDWNHSKDKHLNGAALYSNGHILEALNRPNTLITDANNSLVSI 201

  Fly   210 ARRRARDEKLMTNILQTVRNNGNVLIAVDTAGRVLELAHMLDQLWKNKESGLMAYSLALLNNVSY 274
            ..|:.|||..:.:::.::...|.||:.||.|.|||||..:||..|...:..| .:.:..|:..|.
pombe   202 PSRKKRDEAFIESVMSSLLKGGTVLLPVDAASRVLELCCILDNHWSASQPPL-PFPILFLSPTST 265

  Fly   275 NVIEFAKSQIEWMSDKLTKAFEGARNNPFQFKHIQLCHSLADVYKLPAGPKVVLASTPDLESGFT 339
            ..|::|||.||||.|.:.:.| |...|..:|::|......:.:..:..||||:||:...||.||:
pombe   266 KTIDYAKSMIEWMGDNIVRDF-GINENLLEFRNINTITDFSQISHIGPGPKVILATALTLECGFS 329

  Fly   340 RDLFVQWASNANNSIILTTRTS---PGTLAMELV---ENCAPGK-----------QIELDVRRRV 387
            :.:.:...|..:|.:||.|:.|   ..:||.:.:   |..:..|           :..:.::.:.
pombe   330 QRILLDLMSENSNDLILFTQRSRCPQNSLANQFIRYWERASKKKRDIPHPVGLYAEQAVKIKTKE 394

  Fly   388 DLEGAELEEYLRTQGEKLNP------------LIVKPDVEEESSSESEDDIEMSV---------- 430
            .|||.||..|...:..|.|.            .|:..|:...|||| :||::::.
pombe   395 PLEGEELRSYQELEFSKRNKDAEDTALEFRNRTILDEDLSSSSSSE-DDDLDLNTEVPHVALGSS 458

  Fly   431 --ITGK-HDIVVRPEGRHHSGFFKSNKRHHVMFPYHEEKVKCDEYGEIINLDDYRIADATGYEFV 492
              :.|| .|:.:|...      .::....:.||||.|::.:.|||||||...|:.:.:... ..:
pombe   459 AFLMGKSFDLNLRDPA------VQALHTKYKMFPYIEKRRRIDEYGEIIKHQDFSMINEPA-NTL 516

  Fly   493 PMEEQNKENVKKEEPGIGAEQQANGGI------VDNDVQLLEKPTKLISQRKTIEVNAQVQRIDF 551
            .:|..:.:|......|.....:.|.|:      .|.|    |.|:|:|:..|||.|:.|||.||.
pombe   517 ELENDSDDNALSNSNGKRKWSEINDGLQQKKEEEDED----EVPSKIITDEKTIRVSCQVQFIDI 577

  Fly   552 EGRSDGESMLKILSQLRPRRVIVIHGTAEGTQVVARHCEQNVGA---RVFTPQKGEIIDVTSEIH 613
            ||..||.|:..|:.|:.|||:::||.:.|..:.:.:.| .::.|   .|:.|..||||:|:.:::
pombe   578 EGLHDGRSLKTIIPQVNPRRLVLIHASTEEKEDMKKTC-ASLSAFTKDVYIPNYGEIINVSIDVN 641

  Fly   614 IYQVRLTEGLVSQLQFQKGKDAEVAWVDGRLGMRVKAIEAPMDVTVEQ---DASVQEGKTLTLET 675
            .:.::|.:.|:..|.:.|..:.||:.:..::.:...:.|......||:   |....|.|....||
pombe   642 AFSLKLADDLIKNLIWTKVGNCEVSHMLAKVEISKPSEEEDKKEEVEKKDGDKERNEEKKEEKET 706

  Fly   676 LADDEIPIHNS---------------VLINELKLSDFKQTLMRNNINSEFSG-GVLWCSNGTLAL 724
            |     |:.|:               :|:..::|:..::.|:...|::|..| |||.| .|.:|:
pombe   707 L-----PVLNALTLRSDLARAPRAAPLLVGNIRLAYLRKALLDQGISAELKGEGVLLC-GGAVAV 765

  Fly   725 RRVDAGKVAMEGCLSEEYYKIRELLYEQYAIV 756
            |::..||:::||.||..:::||:|:|:..|:|
pombe   766 RKLSGGKISVEGSLSNRFFEIRKLVYDALAVV 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf100	NP_651658.1	CPSF2-like_MBL-fold	7..204	CDD:293851	72/188 (38%)
		YSH1	19..400	CDD:224157	134/401 (33%)
		Beta-Casp	243..369	CDD:214983	42/128 (33%)
		RMMBL	538..577	CDD:284853	20/38 (53%)
		CPSF100_C	617..753	CDD:290038	40/154 (26%)
cft2	NP_595448.1	YSH1	1..519	CDD:224157	161/521 (31%)
		CPSF2-like_MBL-fold	6..196	CDD:293851	72/188 (38%)
		Beta-Casp	235..361	CDD:214983	42/127 (33%)
		RMMBL	564..602	CDD:284853	19/37 (51%)
		CPSF100_C	645..794	CDD:290038	40/154 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	112	1.000	Domainoid score	I1574
eggNOG	1	0.900	-	-		E1_COG1236
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	335	1.000	Inparanoid score	I505
OMA	1	1.010	-	-		QHG53972
OrthoFinder	1	1.000	-	-		FOG0005213
OrthoInspector	1	1.000	-	-		oto100946
orthoMCL	1	0.900	-	-		OOG6_103283
Panther	1	1.100	-	-	LDO	PTHR45922
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R191
SonicParanoid	1	1.000	-	-		X3727
TreeFam	1	0.960	-	-
	13	12.860