DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cpsf100 and Dclre1c

DIOPT Version :9

Sequence 1:	NP_651658.1	Gene:	Cpsf100 / 43426	FlyBaseID:	FBgn0027873	Length:	756	Species:	Drosophila melanogaster
Sequence 2:	NP_666226.2	Gene:	Dclre1c / 227525	MGIID:	2441769	Length:	705	Species:	Mus musculus

Alignment Length:	842	Identity:	137/842 - (16%)
Similarity:	252/842 - (29%)	Gaps:	327/842 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LHTISGAMDESPPCYILQIDDVRILLDCGWDEKFDANFIKELKRQVHTLDAVLLSHPDAYHLGAL 71
            :.:..|.|.|.|...|               ::||...:|        ..|..|||....|:..|
Mouse     1 MSSFQGQMAEYPTISI---------------DRFDRENLK--------ARAYFLSHCHKDHMKGL 42

  Fly    72 --PYLVGKLGLNCPIYATIPVFKMGQMFMY------DLYMS--HFNMGDFDLFSLDDVDTAFEKI 126
              |.|  |..|.|.:          ::|:|      :|.::  .:...:..:.:::     .|..
Mouse    43 RAPSL--KRRLECSL----------KVFLYCSPVTKELLLTSPKYRFWENRIITIE-----IETP 90

  Fly   127 TQLKYNQTVSLKDKGYG----ISITPLNAGHMIGGTIWKIVKVGEEDIVYATDFNHKK------E 181
            ||      :||.|:..|    :.:|.|.|||..|..:: :.:.....::|..||...|      |
Mouse    91 TQ------ISLVDEASGEKEEVVVTLLPAGHCPGSVMF-LFQGSNGTVLYTGDFRLAKGEASRME 148

  Fly   182 RHLSGCELDRLQRPSLLITDAYNAQYQQARRRARDEKLMTNILQTVRNNGNVLIAVDTAGRVLEL 246
            ...||..:..:|...|..|......||...|    |:.:..||:.||:
Mouse   149 LLHSGGRVKDIQSVYLDTTFCDPRFYQIPSR----EQCLRGILELVRS----------------- 192

  Fly   247 AHMLDQLWKNKESGLMAYSLALLNNVSYNVIEFAKSQIEWMSDKLTKAFEGARNNPFQFKHIQLC 311
                   |..:                      :...:.|::.|....:|....|..:...:|:.
Mouse   193 -------WVTR----------------------SPHHVVWLNCKAAYGYEYLFTNLSEELGVQVH 228

  Fly   312 HSLADVYKLPAGPKVVLASTPDLESGFTRDL--------------FVQW------ASNANNSIIL 356
            ....|::|          :.||:....|.|.              ..||      .::.|.:.:.
Mouse   229 VDKLDMFK----------NMPDILHHLTTDRNTQIHACRHPKAEECFQWNKLPCGITSQNKTALH 283

  Fly   357 TTRTSPGTL-----------------------------------------AMELVENCAPGKQIE 380
            |....|.|:                                         .:.:..|..|   :.
Mouse   284 TISIKPSTMWFGERTRKTNVIVRTGESSYRACFSFHSSFSEIKDFLSYICPVNVYPNVIP---VG 345

  Fly   381 LDVRRRVDLEGAELEEYLRTQGEKLNPLIVKPDVEEES---------------SSESEDDIEMSV 430
            |.|.:.:|:               |.||...|...|..               .||.:||:
Mouse   346 LTVDKVMDV---------------LKPLCRSPQSVEPKYKPLGKLKRARTIHLDSEEDDDL---- 391

  Fly   431 ITGKHDIVVRPEGRHHSGFFKSNKRHHVMFPYHEEKVKCDEYG-EIINLDDYRIADATG------ 488
               ..|.:..|            .||.|  || :..::.:.:. :.:.||...:..:.|
Mouse   392 ---FDDPLPTP------------LRHKV--PY-QLTLQPELFSMKALPLDQPELRQSPGGCKAES 438

  Fly   489 ------YEFVPMEEQNK---ENVKKEEPGIGAEQQANGGIVDNDVQLLEKPTKLISQRKTIEVNA 544
                  ..|:..||.|.   |.::...|.:      .||:         .|:.|:.|....:|:.
Mouse   439 VWSPSLANFIDCEESNSDSGEELETPPPSL------QGGL---------GPSTLVQQNADPDVDI 488

  Fly   545 QVQRIDFEGRSD--GESMLKILSQLRPRRVIVIHGTAEGTQVVA---RHCEQNVGARVFTPQKGE 604
            ....:.|:.|.:  ||.:..:.|.:..       |.::..::.:   :.|..:  .::.:...|:
Mouse   489 PQWEVFFKRRDEITGECLEHLPSSIET-------GGSQSPKLCSDSPKLCSDS--PKLCSDSDGD 544

  Fly   605 IIDVTSEIHIYQVRLTEGLVSQLQFQKGKDAEVAWV--------------------DGRLGMRVK 649
            ...::|:.......:|:      |..:|.|::...|                    ..:|...:.
Mouse   545 STHISSQNSSQSTHITD------QGSQGWDSQCDTVLLSSQEKSGGDSTSLNKGAYKPKLKESIS 603

  Fly   650 AIEAPMDVTVEQD--------ASVQEGKTLT-LETLADDEIPIHNSVL----INELKLSDFK 698
            |.:...|....||        |.|.....|. |:||:..:.|...::|    .:....|||:
Mouse   604 ASQIEQDALCPQDTHCDLKSRAEVNGAPCLVELDTLSGRKSPPEKTLLSSTRADSQSSSDFE 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf100	NP_651658.1	CPSF2-like_MBL-fold	7..204	CDD:293851	45/216 (21%)
		YSH1	19..400	CDD:224157	72/461 (16%)
		Beta-Casp	243..369	CDD:214983	18/186 (10%)
		RMMBL	538..577	CDD:284853	6/40 (15%)
		CPSF100_C	617..753	CDD:290038	21/115 (18%)
Dclre1c	NP_666226.2	artemis-SNM1C-like_MBL-fold	1..171	CDD:293855	45/216 (21%)
		DRMBL	239..343	CDD:284854	11/103 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	451..484		10/47 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	535..569		5/39 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	638..675		7/28 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1236
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900