Protein Alignment Cpsf100 and Ints9

DIOPT Version :10

• Sequence 1: NP_651658.1
• Gene: Cpsf100 / 43426
• FlyBaseID: FBgn0027873
• Length: 756
• Species: Drosophila melanogaster
• Sequence 2: NP_700463.3
• Gene: Ints9 / 210925
• MGIID: 1098533
• Length: 658
• Species: Mus musculus
• Alignment Length: 697
• Identity: 140/697 - (20%)
• Similarity: 251/697 - (36%)
• Gaps: 229/697 - (32%)

  Fly     5 IKLHTISGAMDESPPCYILQIDDVRILLDCGWDEKFDANFI------------------------ 45
            :||:.:||  ..:.||.:|:.....|:||||.|.....||:
Mouse     1 MKLYCLSG--HPTLPCNVLKFKSTTIMLDCGLDMTSTLNFLPLPLVQSPRLSNLPGWSLKDGNAF 63

  Fly    46 --KELKR---------------------QVHTLDAVLLSHPDAYH-LGALPYLVGKLGLNCPIYA 86
              ||||.                     .:.|:|.:|:|:   || :.||||:....|....:||
Mouse    64 LDKELKECSGHVFVDSVPEFCLPETELIDLSTVDVILISN---YHCMMALPYITEHTGFTGTVYA 125

  Fly    87 TIPVFKMGQMFMYDLY-----------MSHFNMGDFD------------------LFSLDDVDTA 122
            |.|..::|::.|.:|.           .|.:...|..                  .:::.:|::|
Mouse   126 TEPTMQIGRLLMEELVNFIERVPKAQSASLWKNKDIQRLLPSPLKDAVEVSTWRRCYTMQEVNSA 190

  Fly   123 FEKITQLKYNQTVSLKDKGYG-ISITPLNAGHMIGGTIWKIVKVGEEDIVYATDFNHKKERHLSG 186
            ..||..:.|:|.:.|    :| :.:|||::|:.:|.:.|.|            ..:::|..::||
Mouse   191 LSKIQLVGYSQKIEL----FGAVQVTPLSSGYALGSSNWII------------QSHYEKVSYVSG 239

  Fly   187 CELDRLQRPSLLITDAYNAQYQQARRRARDEKLMTNILQ-------------------TVRNNGN 232
                    .|||.|  :.....||..:..|..::|.:.|                   ||||.||
Mouse   240 --------SSLLTT--HPQPMDQASLKNSDVLILTGLTQIPTANPDGMVGEFCSNLALTVRNGGN 294

  Fly   233 VLIAVDTAGRVLELAHMLDQLWKNKESGLMAYSLALLNNVSYNVIEFAKSQIEWM-SDKLTKAFE 296
            ||:....:|.:.:|...|.|...:  :||.......::.|:.:.:||::...||: .:|.:|.:
Mouse   295 VLVPCYPSGVIYDLLECLYQYIDS--AGLSNIPFYFISPVANSSLEFSQIFAEWLCHNKQSKVY- 356

  Fly   297 GARNNPF---------QFKHIQLCH-SLADVYKLPAGPKVVLASTPDLESGFTRDLFVQWASNAN 351
             ....||         :.||.:..| ..::.::.|.   |:....|.|..|........|..::.
Mouse   357 -LPEPPFPHAELIQTNKLKHYRSIHGDFSNDFRQPC---VLFTGHPSLRFGDVVHFMELWGKSSL 417

  Fly   352 NSIILT----------------------------------------------------TRTSPGT 364
            |:||.|                                                    |:..|..
Mouse   418 NTIIFTEPDFSYLEALAPYQPLAMKCIYCPIDTRLNFIQVSKLLKEVQPLHVVCPEQYTQPPPAQ 482

  Fly   365 L-AMELVENCAP-------GKQIELDVRRRVDLEGAELEEYLRTQGEKLNPLIVKPDVEEESSS- 420
            . .|:|:.:|.|       .:.:.|..:||.     |..|.:....:.|.|:.:||.:...:.|
Mouse   483 AHRMDLMIDCQPPAMSYRRAEVLALPFKRRY-----EKIEIMPELADSLVPMEIKPGISLATVSA 542

  Fly   421 --ESEDDIEMSVITGKHDIVVRPEGRHHSGFFKSNKRHHVMFPYHEEKVKCDEYGEIINLDDY-R 482
              .::|:        ||.:...|:....:   .|.||..|.....:.||........|.::.: :
Mouse   543 VLHTKDN--------KHVLQPPPKPTQPT---SSKKRKRVNEDIPDCKVLKPLLSGSIPVEQFVQ 596

  Fly   483 IADATGYEFVPMEEQNKENV---KKEEPGIGAEQQANGGIVDNDVQL 526
            ..:..|:..:.:|:..|.::   ::.|..|..|:.:...|.|||..|
Mouse   597 TLEKHGFSDIKVEDTAKGHIVLLQEAETLIQIEEDSTHIICDNDETL 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf100	NP_651658.1	CPSF2-like_MBL-fold	7..204	CDD:293851	60/274 (22%)
		Beta-Casp	243..369	CDD:214983	30/189 (16%)
		RMMBL	539..600	CDD:462191
		CPSF100_C	617..753	CDD:463836
Ints9	NP_700463.3	Int9-like_MBL-fold	1..265	CDD:293852	64/294 (22%)
		Beta-Casp	307..425	CDD:214983	27/124 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	548..572		7/34 (21%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9NV88	566..570		2/3 (67%)