DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cpsf100 and ints-9

DIOPT Version :9

Sequence 1:	NP_651658.1	Gene:	Cpsf100 / 43426	FlyBaseID:	FBgn0027873	Length:	756	Species:	Drosophila melanogaster
Sequence 2:	NP_504953.1	Gene:	ints-9 / 179142	WormBaseID:	WBGene00017608	Length:	646	Species:	Caenorhabditis elegans

Alignment Length:	686	Identity:	140/686 - (20%)
Similarity:	251/686 - (36%)	Gaps:	209/686 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 PCYILQIDDVRILLDCGWD-----------------------EKFDANFIKELKRQVH------- 53
            ||::|:..:.|||:|...|                       :||...::|||..:|:
Worm    13 PCFLLEWPNARILMDTPIDFTPFFSFLPHVYQSPRIKNAPIAKKFQIPYLKELGNRVYVESPPEI 77

  Fly    54 -----------TLDAVLLSHPDAYHLGALPYLVGKLGLNCPIYATIPVFKMGQMFMYDL--YMSH 105
                       |:||:|:|:.::: :| ||:.....|.:..||.|...::.|::.|.::  ::|.
Worm    78 FHVSTDMLKMDTIDAILVSNYESF-VG-LPFYTEGSGFSGKIYVTEIAYQYGKLLMEEMLEFISR 140

  Fly   106 FNM-------------GDF------------DLFSLDDVDTAFEKITQLKYNQTVSLKDKGYGIS 145
            ..:             |.|            ..::..|:.:...|:..|.:|||:.|    :.|.
Worm   141 IEVLPSDKKWKREEFCGKFPNPPFQNPVEWRPYYTTTDMHSCLAKVITLSFNQTIDL----FRIK 201

  Fly   146 ITPLNAGHMIGGTIWKIVKVGEEDIVY-------ATDFNHKKERHLSGCE---LDRLQRPSLLIT 200
            :||:.:||..|...|.| |...|...|       |||....:...|...:   :..|.|  |:.|
Worm   202 VTPVVSGHTYGSAYWTI-KTENEQFAYLSASNPSATDVKLMETAPLRAVDHILVTSLSR--LVDT 263

  Fly   201 DAYNAQYQQARRRARDEKLMTNILQTVRNNGNVLIAVDTAGRVLELAHMLDQLWKNKESGLMAYS 265
            .|....|          .|:..|...::.:|:||:.:...|.:.|:...:..:........:...
Worm   264 TAKEMGY----------SLIKTITDVLKKHGSVLLPICPVGPIFEMIEAVSDIITTTNGIPLDTP 318

  Fly   266 LALLNNVSYNVIEFAKSQIEWMSDKLTKAFEGARNN-------PFQFKHI----------QLCHS 313
            :..::.|:.:.|..|....||||:        :|.|       |:...::          .|..|
Worm   319 IYFISPVAKSAIAMASISAEWMSE--------SRQNAVYLPEEPYSHSNLIKSGRVKIYDSLYGS 375

  Fly   314 LADVYKLPAGPKVVLASTPDLESGFTRDLFVQWASNANNSIILTTRTSPGTLAMELVENCAPGKQ 378
            .:..:|.|.   |:.||...|..|....:.....|:..|::|:|....|.....|...| .|.|.
Worm   376 FSKEFKTPC---VIFASHASLRIGDAAHMVEVLGSDPKNAVIVTDPDLPCEDVREPFRN-LPIKF 436

  Fly   379 IELDVRRRVDLEGAELE--------EYLRTQGEKLNPLIVKPDV----EEESSSESEDDIEMSVI 431
            |.:.:..|:|.  |.||        :|:........|:|.:||:    |:....|.::.:::|.:
Worm   437 INIPMDFRMDF--ASLERLLADAKPKYVLCSSSYTRPMIRRPDMQINYEKVWPIEYDECVQLSKL 499

  Fly   432 T-GKHDIV---VRPEGRHHSGFFKSNKRHHVMFPYHEEK------VKC--DEYGEIINLDDYRIA 484
            : .|..:|   |.||      ..|:.|     |..|..|      :.|  ..|.     ||:::.
Worm   500 SRNKQKLVTVAVHPE------VVKNLK-----FKQHPSKKLAVASIACHLSAYN-----DDFKLV 548

  Fly   485 DATGYEFVPMEEQNKENVKKEEPG-------IGAEQQANGGIVDNDVQLLEKPTKLISQRKTIEV 542
            .|            |..:.:.:.|       :.|.:..|.     |.:.:|||.:.:.:...:|.
Worm   549 PA------------KVKIARRKYGRITLAKVLKALRDKNW-----DAKEVEKPDETVLEIDELEA 596

  Fly   543 NAQVQRIDFEGRSDG----------ESMLKILSQLR 568
            ...|       ::||          |:..|||..:|
Worm   597 KITV-------KNDGTGTKISSNNQENREKILEMIR 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf100	NP_651658.1	CPSF2-like_MBL-fold	7..204	CDD:293851	58/262 (22%)
		YSH1	19..400	CDD:224157	101/483 (21%)
		Beta-Casp	243..369	CDD:214983	25/142 (18%)
		RMMBL	538..577	CDD:284853	9/41 (22%)
		CPSF100_C	617..753	CDD:290038
ints-9	NP_504953.1	metallo-hydrolase-like_MBL-fold	1..256	CDD:390040	53/249 (21%)
ints-9	NP_504953.1	Beta-Casp	298..416	CDD:214983	23/128 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1236
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810