Protein Alignment Cpsf100 and cpsf-2

DIOPT Version :9

• Sequence 1: NP_651658.1
• Gene: Cpsf100 / 43426
• FlyBaseID: FBgn0027873
• Length: 756
• Species: Drosophila melanogaster
• Sequence 2: NP_504822.1
• Gene: cpsf-2 / 179103
• WormBaseID: WBGene00017313
• Length: 843
• Species: Caenorhabditis elegans
• Alignment Length: 864
• Identity: 347/864 - (40%)
• Similarity: 501/864 - (57%)
• Gaps: 129/864 - (14%)

  Fly     1 MTSIIKLHTISGAMDESPPCYILQIDDVRILLDCGWDEKFDANFIKELKRQVHTLDAVLLSHPDA 65
            |||||||...|||.||.|.||:||:|...|||||||||:|...:.:|||..:..:.|||:||||.
 Worm     1 MTSIIKLKVFSGAKDEGPLCYLLQVDGDYILLDCGWDERFGLQYFEELKPFIPKISAVLISHPDP 65

  Fly    66 YHLGALPYLVGKLGLNCPIYATIPVFKMGQMFMYDLYMSHFNMGDFDLFSLDDVDTAFEKITQLK 130
            .|||.|||||.|.||..|:|||:||:||||||:||:..||.::.:|:.::||||||||||:.|:|
 Worm    66 LHLGGLPYLVSKCGLTAPVYATVPVYKMGQMFIYDMVYSHLDVEEFEHYTLDDVDTAFEKVEQVK 130

  Fly   131 YNQTVSLKDKGYGISITPLNAGHMIGGTIWKIVKVGEEDIVYATDFNHKKERHLSGCELDRLQRP 195
            |||||.||... |:..|.|.||||:||:||:|.:|..|||||..||||||||||:||..|...||
 Worm   131 YNQTVVLKGDS-GVHFTALPAGHMLGGSIWRICRVTGEDIVYCVDFNHKKERHLNGCSFDNFNRP 194

  Fly   196 SLLITDAYNAQYQQARRRARDEKLMTNILQTVRNNGNVLIAVDTAGRVLELAHMLDQLWKNKESG 260
            .||||.|::....|.||:.|||:|:|.||:|||..|:.:|.:|||||||||||:|||||.|.::|
 Worm   195 HLLITGAHHISLPQMRRKDRDEQLVTKILRTVRQKGDCMIVIDTAGRVLELAHLLDQLWSNADAG 259

  Fly   261 LMAYSLALLNNVSYNVIEFAKSQIEWMSDKLTK-AFEGARNNPFQFKHIQLCHSLADVYKLPAGP 324
            |..|:|.::::|:.:|::|||||:|||::||.| ....||.|||..||:.||||..::.:: ..|
 Worm   260 LSTYNLVMMSHVASSVVQFAKSQLEWMNEKLFKYDSSSARYNPFTLKHVTLCHSHQELMRV-RSP 323

  Fly   325 KVVLASTPDLESGFTRDLFVQWASNANNSIILTTRTSPGTLAMELV---ENCAPG------KQIE 380
            ||||.|:.|:||||:|:||:.|.|:..|.:|||.|.:..|||.:||   |....|      :.|.
 Worm   324 KVVLCSSQDMESGFSRELFLDWCSDPRNGVILTARPASFTLAAKLVNMAERANDGVLKHEDRLIS 388

  Fly   381 LDVRRRVDLEGAELEEYLRTQGEKLNPLIVKPDVEE---------------ESSSESEDDIEMSV 430
            |.|::||.|||.||.||.|.:.|:        |.||               ||....:|||...:
 Worm   389 LVVKKRVALEGEELLEYKRRKAER--------DAEETRLRMERARRQAQANESDDSDDDDIAAPI 445

  Fly   431 ITGKH------------------DIVVRPEGRHHSGFFKSNKRHHVMFPYHEEKVKCDEYGEIIN 477
            :. :|                  ||:.:.:.:..:.|||:.|:...||||.|||||.|:|||:|.
 Worm   446 VP-RHSEKDFRSFDGSENDAHTFDIMAKWDNQQKASFFKTTKKSFPMFPYIEEKVKWDDYGEVIK 509

  Fly   478 LDDYRIADATGYEFVPMEEQNKENVKKEEPGIGAEQQANGGIVDNDVQLLEKPTKLISQRKTIEV 542
            .:||.:......         ::...|:||.:..:::....:.:.:..:.|.|||.:..:..:||
 Worm   510 PEDYTVISKIDL---------RKGQNKDEPVVVKKREEEEEVYNPNDHVEEMPTKCVEFKNRVEV 565

  Fly   543 NAQVQRIDFEGRSDGESMLKILSQLRPRRVIVIHGTAEGTQ-VVARHCEQNVGARVF-TPQKGEI 605
            :.:::.|::||.|||||..|:|:.|.||::||:||:.:.|: :||...:......:. .|:.|.:
 Worm   566 SCRIEFIEYEGISDGESTKKLLAGLLPRQIIVVHGSRDDTRDLVAYFADSGFDTTMLKAPEAGAL 630

  Fly   606 IDVTSEIHIYQVRLTEGLVSQLQFQKGKDA-EVAWVDGRLGMRVKAIEAPM----------DVTV 659
            :|.:.|..||||.|::.|::.:||::..:. .:||:|.|: |..:||:..:          |...
 Worm   631 VDASVESFIYQVALSDALLADIQFKEVSEGNSLAWIDARV-MEKEAIDNMLAVGTSNLMIDDKNR 694

  Fly   660 EQDASVQE----------------GKTLTLETLADDE---------------------------- 680
            |:|.:.||                |:..:.|:||..|
 Worm   695 EEDVNDQEENGATEGEGNAEPMEIGENGSQESLAISESGKEVENGHTNDSRTKKGTKGKIRGNLI 759

  Fly   681 --------IPIHNSVLINELKLSDFKQTLMRNNINSEFSGGVLWCSNGTLALRRVDAGKVAMEGC 737
                    ||||.:|.:|:.||||||..|......:||..|.|..:.|..::||.|.|...|||.
 Worm   760 LDPLPKRLIPIHQAVFVNDPKLSDFKNLLTDKGYKAEFLSGTLLINGGNCSIRRNDTGVFQMEGA 824

  Fly   738 LSEEYYKIRELLYEQYAIV 756
            .:::|||:|.|.|:|:|::
 Worm   825 FTKDYYKLRRLFYDQFAVL 843

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf100	NP_651658.1	CPSF2-like_MBL-fold	7..204	CDD:293851	117/196 (60%)
		YSH1	19..400	CDD:224157	210/390 (54%)
		Beta-Casp	243..369	CDD:214983	64/126 (51%)
		RMMBL	538..577	CDD:284853	17/38 (45%)
		CPSF100_C	617..753	CDD:290038	53/198 (27%)
cpsf-2	NP_504822.1	RMMBL	562..601	CDD:284853	18/38 (47%)
		CPSF100_C	642..840	CDD:290038	53/198 (27%)
		YSH1	10..376	CDD:224157	203/367 (55%)
		CPSF2-like_MBL-fold	10..203	CDD:293851	116/193 (60%)
		Beta-Casp	242..368	CDD:214983	64/126 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159490
Domainoid	1	1.000	221	1.000	Domainoid score	I1494
eggNOG	1	0.900	-	-		E1_COG1236
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6460
Inparanoid	1	1.050	611	1.000	Inparanoid score	I492
Isobase	1	0.950	-	0	Normalized mean entropy	S2127
OMA	1	1.010	-	-		QHG53972
OrthoDB	1	1.010	-	-		D129179at33208
OrthoFinder	1	1.000	-	-		FOG0005213
OrthoInspector	1	1.000	-	-		oto18745
orthoMCL	1	0.900	-	-		OOG6_103283
Panther	1	1.100	-	-	LDO	PTHR45922
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R191
SonicParanoid	1	1.000	-	-		X3727
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750