DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cpsf100 and cpsf-3

DIOPT Version :9

Sequence 1:	NP_651658.1	Gene:	Cpsf100 / 43426	FlyBaseID:	FBgn0027873	Length:	756	Species:	Drosophila melanogaster
Sequence 2:	NP_502553.2	Gene:	cpsf-3 / 178285	WormBaseID:	WBGene00013460	Length:	707	Species:	Caenorhabditis elegans

Alignment Length:	727	Identity:	152/727 - (20%)
Similarity:	272/727 - (37%)	Gaps:	196/727 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 CYILQIDDVRILLDCGWD---EKFDA----NFIKELKRQVHTLDAVLLSHPDAYHLGALPYLVGK 77
            |::|:....|::||||..   ...||    :|:     ::..:|.:|::|....|.||||:|:.|
Worm    26 CHLLEYKGKRVMLDCGVHPGLHGVDALPFVDFV-----EIENIDLLLITHFHLDHCGALPWLLQK 85

  Fly    78 LGLNCPIYATIPVFKMGQMFMYDLYMSHFNMGDFD---LFSLDDVDTAFEKITQLKYNQTVSLKD 139
            .......:.|.....:.:|.:.| |:.....|..|   |::.||::.:..||..:.:.:...:.
Worm    86 TAFQGKCFMTHATKAIYRMLLGD-YVRISKYGGPDRNQLYTEDDLEKSMAKIETIDFREQKEVN- 148

  Fly   140 KGYGISITPLNAGHMIGGTIWKIVKVGEEDIVYATDFNHKKERHLSGCELDRLQRPSLLITDAYN 204
               ||...|..|||::|...: ::::....::|..||:..::|||...|:..: .|.:|||::..
Worm   149 ---GIRFWPYVAGHVLGACQF-MIEIAGVRVLYTGDFSCLEDRHLCAAEIPPI-TPQVLITESTY 208

  Fly   205 AQYQQARRRARDEKLMTNILQTVRNNGNVLIAVDTAGRVLELAHMLDQLWKNKESGLMAYSLALL 269
            .......|..|:::....:...|...|..||.....|...||..:||:.|::.:. |....:...
Worm   209 GTQTHEDRAVREKRFTQMVHDIVTRGGRCLIPAFAIGPAQELMLILDEYWESHQE-LHDIPVYYA 272

  Fly   270 NNVSYNVIEFAKSQIEWMSDKLTKAFEGARNNPFQFKHIQLCHSLADVYKLPAGPKVVLASTPDL 334
            ::::...:...::.:..|:.::.|..  |..|||.|||:.....: |.:: .|||.||||:...|
Worm   273 SSLAKKCMSVYQTFVNGMNSRIQKQI--AVKNPFIFKHVSTLRGM-DQFE-DAGPCVVLATPGML 333

  Fly   335 ESGFTRDLFVQWASNANNSIILTTRTSPGTLAMELVENCAPGKQIELDVRRRVDLEGAELEEYLR 399
            :|||:|:||..|..:..|..|:......||||..::                     :|.||.:.
Worm   334 QSGFSRELFESWCPDTKNGCIIAGYCVEGTLAKHIL---------------------SEPEEIVS 377

  Fly   400 TQGEKLNPLIVKPDVEEESSSESEDDIEMSVITGKHDIVVRPEGRHHSGFFKSNKRHHVMFPYHE 464
            ..|||| |:.::...           :..|..|..|..         |.|.|:.|..|::.
Worm   378 LSGEKL-PMRMQVGY-----------VSFSAHTDYHQT---------SNFVKALKPPHLVL---- 417

  Fly   465 EKVKCDEYGEIINLDDYRIADATGYEF----VPMEEQNKENVKKEEPGIGAEQQANGGIVDNDVQ 525
                  .:||:..:.  |:......:|    :|:|..|..|
Worm   418 ------VHGELHEMS--RLKSGIERQFQDDNIPIEVHNPRN------------------------ 450

  Fly   526 LLEKPTKLISQRKTIEVNAQVQRIDFEGRSDGESMLKILSQLRPRRVIVIHGTAEGTQVVARHCE 590
                                .:|:..:.|  ||...|::.:| .:||...:.|..|..|     :
Worm   451 --------------------TERLQLQFR--GEKTAKVIGKL-AQRVPENNETISGVLV-----K 487

  Fly   591 QNVGARVFTPQKGEIIDVTSEIHIYQVRLTEGLVSQLQFQKGKDAEVAWVDGRLGMRVKAIEAPM 655
            .|....:..|:  |:...||                                   :|:.::|..|
Worm   488 NNFSYSIMVPE--ELGSYTS-----------------------------------LRISSLEQRM 515

  Fly   656 DVTVEQDASVQEGKTLTLETLADDEIPIHNSVLINELKLSDFKQ--------TLMRNNINSEFSG 712
            .|.......:   ....|:.|.||      :.||..:||.:..:        |:.:..:|....|
Worm   516 SVHYSGSLKL---LIFNLQQLNDD------ACLIQNIKLKEISKKGSVTQAITVFQGKVNVTVYG 571

  Fly   713 G-----VLWCSN 719
            .     |.|.||
Worm   572 NDHVVVVRWDSN 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf100	NP_651658.1	CPSF2-like_MBL-fold	7..204	CDD:293851	49/193 (25%)
		YSH1	19..400	CDD:224157	96/389 (25%)
		Beta-Casp	243..369	CDD:214983	37/125 (30%)
		RMMBL	538..577	CDD:284853	8/38 (21%)
		CPSF100_C	617..753	CDD:290038	19/116 (16%)
cpsf-3	NP_502553.2	CPSF3-like_MBL-fold	11..206	CDD:293850	49/191 (26%)
		YSH1	13..456	CDD:224157	118/544 (22%)
		Beta-Casp	247..368	CDD:214983	37/125 (30%)
		RMMBL	381..421	CDD:284853	12/70 (17%)
		CPSF73-100_C	477..694	CDD:215023	27/158 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1236
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810