Protein Alignment Cpsf100 and mrt-1

DIOPT Version :10

• Sequence 1: NP_651658.1
• Gene: Cpsf100 / 43426
• FlyBaseID: FBgn0027873
• Length: 756
• Species: Drosophila melanogaster
• Sequence 2: NP_740895.1
• Gene: mrt-1 / 172666
• WormBaseID: WBGene00045237
• Length: 608
• Species: Caenorhabditis elegans
• Alignment Length: 685
• Identity: 118/685 - (17%)
• Similarity: 211/685 - (30%)
• Gaps: 305/685 - (44%)

  Fly    90 VFKMGQMFM--YDLYMSH------FNMGDFDLFSLDDVDTAFEKITQLK--------YNQTVSLK 138
            |.:.|:.|:  .|:|..|      .|.|||  .:|.:|..|...:|:::        ||:
 Worm    91 VEESGKEFLIEIDVYDDHRIGIEKLNSGDF--VALQNVHAASVGLTEMQVLHGGGQAYNR----- 148

  Fly   139 DKGYGISITPLNAGHMIGGTIWKIVKVGEEDIVYATDFNHKKERHLSGCELDRLQRPSLLITDAY 203
                |||..|::    .....::|.|...|.::.|                         :||..
 Worm   149 ----GISKVPVD----FRNEAFQIFKKRVESVLEA-------------------------VTDCD 180

  Fly   204 N-AQYQQARRRARDEKLMTNILQTVRNNGNVLIAVDTAGRVLELAHMLDQLWKNKESGLMAYSLA 267
            | .::||.....:.|    ...||..:|        |:|.. :|.|              ...:.
 Worm   181 NFIEFQQKENVVQSE----TSTQTSSSN--------TSGDA-DLKH--------------CQQIK 218

  Fly   268 LLNNVSYNVIEFAKSQIEWMSDKLTKAFEGARNNPFQFKHIQLCHSLADVYKLPAGPKVVLASTP 332
            :..::|          :::...|     .|:|.|       .|.|:.:|.|:
 Worm   219 IGEDIS----------VDYFLKK-----SGSRYN-------FLTHAHSDHYR------------- 248

  Fly   333 DLESGFTRDLFVQWASNANNSIILTTRTSPGTLAMELVENCAPGKQIELDVRRRVDLEGAELEEY 397
            .|:..:||.::                             |:|              |.|:|..:
 Worm   249 GLDKKWTRSVY-----------------------------CSP--------------ETAKLLPH 270

  Fly   398 LR-------TQGEKLNPLIVKPDVEEESSSESEDDIEMSVITGKHDIVVRPEGRHHSGFFKSNKR 455
            :.       .....:|||       ||:.....|..:::::...|    .|..
 Worm   271 IMGYTADSPPPAGLINPL-------EENVPHKFDSFQVTLVNANH----CPGA------------ 312

  Fly   456 HHVMFPYHEEKVKCDEYGEIINLDDYRIAD---------------ATGYEF-------------V 492
              |||.:...|::....|.::...|:| ||               .|..:|             :
 Worm   313 --VMFVFEGSKIEEIAGGAVLCTGDFR-ADKMFLESLKPGNQLHWMTEIKFGIIYLDNTYFSLDM 374

  Fly   493 PMEEQNK--------------ENVKKEEPGIGAEQQANGGIVDNDVQLLEKPTKLISQRKTIEVN 543
            |..|:.:              ||:......:|.|:     ::....::|.:|..:..:||.|.
 Worm   375 PFPERCEAEKILLKAIEAHPHENIVIPLHRLGREE-----LIQAISRILNEPIMVYDERKVIS-- 432

  Fly   544 AQVQRIDFEGRSDGESMLKILSQLRPRRVIVIHGTAEGTQVVARHCEQNVGARVFTPQKGEIIDV 608
               ..:||      .|...:|.|.|..:||     .:|:     :||        ..|...|||:
 Worm   433 ---DLLDF------SSNCGVLKQYRDIKVI-----KKGS-----YCE--------ISQNSVIIDI 470

  Fly   609 TSEIHIY--QVRLTEGLV-----------------SQLQF-------QKGKDAEVAWVDGRLGMR 647
            :...:.:  .|...||::                 |...|       :|....|:|.:: ..|.|
 Worm   471 SMLYYTFGNGVNDDEGIIRIPYSDHSSRSEILKFLSHFHFKTITPCTKKYSIIELASLE-NAGKR 534

  Fly   648 VKAIEAPMDVTVEQDASVQEGKTLTLETLADDEIP 682
                 :..|.|||:..|..:|..::  .|.:|.:|
 Worm   535 -----SEEDHTVEKTQSTIQGTPIS--QLQEDPLP 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf100	NP_651658.1	CPSF2-like_MBL-fold	7..204	CDD:293851	26/129 (20%)
		Beta-Casp	243..369	CDD:214983	14/125 (11%)
		RMMBL	539..600	CDD:462191	12/60 (20%)
		CPSF100_C	617..753	CDD:463836	19/90 (21%)
mrt-1	NP_740895.1	hPOT1_OB2	27..170	CDD:239944	22/93 (24%)
		metallo-hydrolase-like_MBL-fold	212..371	CDD:451500	37/276 (13%)
		DRMBL	<478..515	CDD:429512	5/36 (14%)