DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cpsf100 and cpsf2

DIOPT Version :9

Sequence 1:	NP_651658.1	Gene:	Cpsf100 / 43426	FlyBaseID:	FBgn0027873	Length:	756	Species:	Drosophila melanogaster
Sequence 2:	NP_001120452.1	Gene:	cpsf2 / 100145546	XenbaseID:	XB-GENE-950595	Length:	783	Species:	Xenopus tropicalis

Alignment Length:	806	Identity:	426/806 - (52%)
Similarity:	557/806 - (69%)	Gaps:	73/806 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTSIIKLHTISGAMDESPPCYILQIDDVRILLDCGWDEKFDANFIKELKRQVHTLDAVLLSHPDA 65
            |||||||.|::||.:||..||:||:|:.|.||||||||.|..:.|..:|:.||.:|||||||||.
Frog     1 MTSIIKLTTLAGAQEESAVCYLLQVDEFRFLLDCGWDENFSMDIIDSVKKYVHQVDAVLLSHPDP 65

  Fly    66 YHLGALPYLVGKLGLNCPIYATIPVFKMGQMFMYDLYMSHFNMGDFDLFSLDDVDTAFEKITQLK 130
            .|||||||.||||||||.||:||||:|||||||||||.|..|..||.||||||||.||:||.|||
Frog    66 LHLGALPYAVGKLGLNCAIYSTIPVYKMGQMFMYDLYQSRHNTEDFSLFSLDDVDCAFDKIQQLK 130

  Fly   131 YNQTVSLKDKGYGISITPLNAGHMIGGTIWKIVKVGEEDIVYATDFNHKKERHLSGCELDRLQRP 195
            |:|.|.||.||:|:|||||.||||||||||||||.|||:||||.|||||:|.||:||.|:.:.||
Frog   131 YSQIVHLKGKGHGLSITPLPAGHMIGGTIWKIVKDGEEEIVYAVDFNHKREIHLNGCSLEMISRP 195

  Fly   196 SLLITDAYNAQYQQARRRARDEKLMTNILQTVRNNGNVLIAVDTAGRVLELAHMLDQLWKNKESG 260
            ||||||.:||.|.|.||:.|||:|:||:|:|:|.:|||||||||||||||||.:|||:|:.|::|
Frog   196 SLLITDCFNATYVQPRRKQRDEQLLTNVLETLRGDGNVLIAVDTAGRVLELAQLLDQIWRTKDAG 260

  Fly   261 LMAYSLALLNNVSYNVIEFAKSQIEWMSDKLTKAFEGARNNPFQFKHIQLCHSLADVYKLPAGPK 325
            |..|||||||||||||:||:|||:|||||||.:.||..|||||||:|:.|||..:|:.::|: ||
Frog   261 LGVYSLALLNNVSYNVVEFSKSQVEWMSDKLMRCFEDKRNNPFQFRHLTLCHGFSDLARVPS-PK 324

  Fly   326 VVLASTPDLESGFTRDLFVQWASNANNSIILTTRTSPGTLAMELVENCAPGKQ-IELDVRRRVDL 389
            |||||.||||.||:|:||:||..:..||:|||.||:|||||..|:::  |.:: |::::|:||.|
Frog   325 VVLASQPDLECGFSRELFIQWCQDPKNSVILTYRTTPGTLARFLIDH--PSERIIDIELRKRVKL 387

  Fly   390 EGAELEEYLRTQGEKLNPLIVK-------PDVEEESSSESEDDIEMSVI-TGKHDIVVRPEGRHH 446
            ||.||||||  :.|||.....|       .|::....|::|:||:.:.. ..|||::::.||...
Frog   388 EGKELEEYL--EKEKLKKEAAKKLEQSKEADLDSSDDSDAEEDIDQTTSHKAKHDLMMKNEGSRK 450

  Fly   447 SGFFKSNKRHHVMFPYHEEKVKCDEYGEIINLDDYRIADATGYEFVPMEEQNKENVKKEEPGIGA 511
            ..|||..|:.:.|||..||::|.|||||||..:|:         .||..:..::...|.|.|:
Frog   451 GSFFKQAKKSYPMFPAPEERIKWDEYGEIIKPEDF---------LVPELQATEDEKTKLESGL-- 504

  Fly   512 EQQANGGIVDNDVQLLEKPTKLISQRKTIEVNAQVQRIDFEGRSDGESMLKILSQLRPRRVIVIH 576
                ..|....|..|.:.|||.||..:::|:.|:|..||:||||||:|:.||::|::||::|::|
Frog   505 ----TNGEEPMDQDLSDVPTKCISATESMEIKARVTYIDYEGRSDGDSIKKIINQMKPRQLIIVH 565

  Fly   577 GTAEGTQVVARHCEQNVG--ARVFTPQKGEIIDVTSEIHIYQVRLTEGLVSQLQFQKGKDAEVAW 639
            |..:.||.:|..|....|  .:|:||:..|.:|.|||.|||||||.:.|||.|:|.|.||.|:||
Frog   566 GPPDATQDLAEACRAFGGKDIKVYTPKLHETVDATSETHIYQVRLKDSLVSSLKFCKAKDTELAW 630

  Fly   640 VDGRLGMRVKAIEAPMDVTVEQDASVQEG-----------------------KTL---------- 671
            :||.|.|||..::.  .|.:|:.....||                       |:|
Frog   631 IDGVLDMRVSKVDT--GVILEEGELKDEGEDSEMQVDTQALDASAIAQQKAIKSLFGDDDKEFSE 693

  Fly   672 ------TLETLADDEIPIHNSVLINELKLSDFKQTLMRNNINSEFSGGVLWCSNGTLALRRVDAG 730
                  |||.|..:|:|.|.||.:||.:||||||.|:|..|.:||.||||.|:| .:|:||.:.|
Frog   694 ESEIIPTLEPLPSNEVPGHQSVFMNEPRLSDFKQVLLREGIQAEFVGGVLVCNN-MVAVRRTETG 757

  Fly   731 KVAMEGCLSEEYYKIRELLYEQYAIV 756
            ::.:||||.|:::|||||||||||||
Frog   758 RIGLEGCLCEDFFKIRELLYEQYAIV 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf100	NP_651658.1	CPSF2-like_MBL-fold	7..204	CDD:293851	138/196 (70%)
		YSH1	19..400	CDD:224157	256/381 (67%)
		Beta-Casp	243..369	CDD:214983	82/125 (66%)
		RMMBL	538..577	CDD:284853	18/38 (47%)
		CPSF100_C	617..753	CDD:290038	71/174 (41%)
cpsf2	NP_001120452.1	CPSF2-like_MBL-fold	7..204	CDD:293851	138/196 (70%)
		Beta-Casp	243..368	CDD:214983	82/125 (66%)
		RMMBL	528..591	CDD:377862	26/62 (42%)
		CPSF100_C	608..780	CDD:372551	71/174 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	261	1.000	Domainoid score	I1922
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H6460
Inparanoid	1	1.050	811	1.000	Inparanoid score	I475
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D129179at33208
OrthoFinder	1	1.000	-	-		FOG0005213
OrthoInspector	1	1.000	-	-		oto103198
Panther	1	1.100	-	-	LDO	PTHR45922
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3727
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160