DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1951 and SCY1

DIOPT Version :9

Sequence 1:	NP_651655.1	Gene:	CG1951 / 43423	FlyBaseID:	FBgn0039623	Length:	835	Species:	Drosophila melanogaster
Sequence 2:	NP_011432.1	Gene:	SCY1 / 852797	SGDID:	S000003051	Length:	804	Species:	Saccharomyces cerevisiae

Alignment Length:	817	Identity:	189/817 - (23%)
Similarity:	365/817 - (44%)	Gaps:	122/817 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 WKVYNGHKKSTK----QEVSVFVFEKKSLERW--------SKD-DRETML-----ETLRRGVQQL 92
            |.:|.|..||:.    .:||:|:|:||..|.:        ||. .|:.:|     |.||.....|
Yeast    27 WSIYTGRPKSSSSSSPSKVSIFMFDKKQFENYLLHYGIIKSKSGSRDKVLIQEAYEILRNQANNL 91

  Fly    93 TKIRHPHVLTVQHPLEESRDSLAFATEPVFASLANVVGDNVRSEKKLY------DVEIRHGLLQL 151
            .|::||::||:..||||...:..|.||.|.:||..|..:....|:...      ::.::.|:|||
Yeast    92 AKLKHPNILTLIEPLEEHSKNFMFVTEFVTSSLETVFRETDDEEQNFLQGHVKDNIVVQRGILQL 156

  Fly   152 FDGLQFLHQDAKIVHRNISAETIVINKNRSWKLFGFDFCIANQPATDGTPHWPFREYTTSLHVLA 216
            .:.|.|:|..|..||.||....|.||:|..||:.|..:.:...|.|: |..:...:|...:....
Yeast   157 VNALDFVHNRASFVHLNIQPRAIFINENSDWKISGLGYLVKIPPGTN-TSEYFLPQYDPRVPPFM 220

  Fly   217 QPSLEYTAPELALNSVNTPDSDLFSLGVLIFTIYAGKPLKMFGSDYSS------FRRYANDLNQR 275
            ...|.|||||:...:..|..:|.||||:||:.:|.||.|  |.|:.|:      :.::.:.::..
Yeast   221 HLQLNYTAPEIVFENTLTFKNDYFSLGLLIYFLYTGKDL--FRSENSTSEYKLEYNKFESKISTM 283

  Fly   276 KYPPM-NAVPSELTESLKALLHPSANLR-PKLHELKQIAYFQDVGVKTLSYLDSLYQWDNLQKSK 338
            .:..: :.||.:|...:..|::.....| ..:..:....:|||..||||::||.|...:|.:|..
Yeast   284 SWDNIFSKVPQKLRHCIPKLINRDIYSRYDNITLILDSEFFQDPLVKTLNFLDDLPTKNNEEKYV 348

  Fly   339 FYKGLPQIIPTLPHRVNLHSILPYLV--------KEFVNSPMIPFVLPNVLLIAEMSSQREYCDH 395
            |.:||..::|..|..:.....||.|:        ::.|:...:...|..::.|....||..:.:.
Yeast   349 FLEGLVNLLPEFPPALLQKKFLPILLELLSQFCAEKVVSDKCVGKSLDLIIKIGSTLSQLSFQEK 413

  Fly   396 ILPHLKPIFKLTD---PI---QILLIFMQKMDLLLKLTPAEEVKQSVLPLLYRSL----ECDMPQ 450
            :.|.|     |:|   |:   :..:..:..:|.|.:.....:..:::|..|:..:    |.|:..
Yeast   414 VYPVL-----LSDANFPVLLKKATICLIDNLDTLKQKVKRSDFLENILKPLFNYVLHDSESDITV 473

  Fly   451 I-QDLCLAVLPTFSTLIDYNAMKNSVLPRIKKLCLQSSNVSVKVNCLISIGKLLE--NLDKWLVL 512
            : |:..|:.:|....::|:..:|..:||.:..|..::::::||..|:.....::|  ::|.:...
Yeast   474 VCQEKLLSQIPLALEVLDFPTVKQFLLPLLSNLFTKTTSLTVKNTCVTCFQIMIEHKSIDSYTCS 538

  Fly   513 DEILPFLQQIQSREPAIIMGIIGIYKIAMTNTKLGITKD-VMAHKCIPYLVPLSVENGLTIAQFN 576
            :.:||..:.:::|:|.|:..::.:::    ...|.||.: |:..:.:|.:...|:.:.||.:|::
Yeast   539 ETVLPLFKSMKTRDPRILSKLLKLFE----TVPLIITDEIVLVDQVLPLMWNYSMASTLTKSQYS 599

  Fly   577 TIISLIKEMMGRVEQEQREKL-QQLSTIQRD----------NKPKDASEILANELENSTLSPYGS 630
            .....|.:|...:::....|| .:::.|..|          .|.:|...:.|..:|.:.:.|...
Yeast   600 GYTKAINKMSSDIQKHHIAKLDDKVNDIGEDAFHKVIEPTIMKKEDPETVAAKNIEVAAMQPVKK 664

  Fly   631 INGNKINDDMFSGFTVGQPKAAIGA-AIAPAKAREQLKISHNTISAPPAARPDILSSMMQSNLTG 694
            ..|:..      |.|:.|.|:.:.: .:.|..|..........:::||         ...|:.||
Yeast   665 KTGSSY------GETLPQSKSILNSKPLNPKNALATRGFPTRILNSPP---------QTPSSRTG 714

  Fly   695 LGTITVAAAPPPTTTQMPSN-NGWHSANPLVMNHQLASPQASNNNSFSLDDLDPFAGGRPSVGAP 758
            ...:|...:...::|::... |.:.|.:......|.::|.            |.:....||....
Yeast   715 SKVMTKGGSNDASSTKVEEEFNEFQSFSSTGSIRQTSAPS------------DVWMNSTPSPTPT 767

  Fly   759 KANNTNGANMYTVQQPTVNYIYPTGYSLNSIQQHQQQ 795
            .|::||               .|.|:|: |:|.::::
Yeast   768 SASSTN---------------LPPGFSI-SLQPNKRK 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1951	NP_651655.1	Pkinase	31..314	CDD:278497	86/299 (29%)
		PK_SCY1_like	37..316	CDD:270913	87/301 (29%)
		HEAT repeat	396..425	CDD:293787	7/34 (21%)
		HEAT repeat	435..465	CDD:293787	7/34 (21%)
		HEAT repeat	474..501	CDD:293787	6/26 (23%)
SCY1	NP_011432.1	PK_SCY1_like	18..326	CDD:270913	87/301 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343961
Domainoid	1	1.000	111	1.000	Domainoid score	I1377
eggNOG	1	0.900	-	-		E1_KOG2137
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	195	1.000	Inparanoid score	I883
Isobase	1	0.950	-	0	Normalized mean entropy	S3280
OMA	1	1.010	-	-		QHG54564
OrthoFinder	1	1.000	-	-		FOG0003248
OrthoInspector	1	1.000	-	-		otm46832
orthoMCL	1	0.900	-	-		OOG6_102086
Panther	1	1.100	-	-	LDO	PTHR12984
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5334
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.740