DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1951 and AT1G22870

DIOPT Version :9

Sequence 1:	NP_651655.1	Gene:	CG1951 / 43423	FlyBaseID:	FBgn0039623	Length:	835	Species:	Drosophila melanogaster
Sequence 2:	NP_173700.2	Gene:	AT1G22870 / 838892	AraportID:	AT1G22870	Length:	913	Species:	Arabidopsis thaliana

Alignment Length:	892	Identity:	250/892 - (28%)
Similarity:	415/892 - (46%)	Gaps:	130/892 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 QTVSTLSGVLPGNNVTREYEVLEQVCTAGVGLMWKVYNGH-KKSTKQE----VSVFVFEKKSLER 72
            :||.|....:.|....::||:|:|:.:.|.||.||:|:.. :.||:.:    |.|:|.:|::|..
plant    21 KTVQTTVQEVTGPKPLQDYELLDQIGSGGPGLAWKLYSAKARDSTRPQQYPTVCVWVLDKRALSE 85

  Fly    73 ------WSKDDRETMLETLRRGVQQLTKIRHPHVLTVQHPLEESRDSLAFATEPVFASLANVVG- 130
                  .||...:..|:.:|....:|.::|||.|:.|...|:|:::::|..|||:|||:||.:|
plant    86 ARARAGLSKAAEDAFLDLIRADSGKLVRLRHPGVVHVVQALDENKNAMAMVTEPLFASVANALGN 150

  Fly   131 ----DNVRSEKKLYD---VEIRHGLLQLFDGLQFLHQDAKIVHRNISAETIVINKNRSWKLFGFD 188
                |||..:.|..:   :|::|||||:.:.|.|||.:|.::||.:|.|.:.|....||||.||.
plant   151 VENVDNVPKDLKSMEMSLLEVKHGLLQIAETLNFLHNNAHLIHRAVSPENVFITSAGSWKLAGFG 215

  Fly   189 FCIANQPATDGT----PHWPFREYTTSLHVL-AQPSLEYTAPELALNSVNTP--DSDLFSLGVLI 246
            |.|:.  |.||.    ..:.:.||.....:| .||||.||||||..:..::.  .||:||.|.|.
plant   216 FAISQ--AQDGNLDNLQSFHYSEYDVEDSILPLQPSLNYTAPELVRSKTSSAGVSSDIFSFGCLT 278

  Fly   247 FTIYAGKPLKMFGSDYSSFRRYANDLNQRKYPPMNAVPSELTESLKALLHPSANLRPKLHELKQI 311
            :.:.|.|||  |.. :::.:.|.|.||.......:::||:|...|:.:|..:.:.||...:....
plant   279 YHLVARKPL--FDC-HNNVKMYMNTLNYLTNETFSSIPSDLVSDLQRMLSMNESYRPTALDFTGS 340

  Fly   312 AYFQ-DVGVKTLSYLDSLYQWDNLQKSKFYKGLPQIIPTLPHRVNLHSILPYLVKEFVNSPMIPF 375
            ::|: |..::.|.:||.:.:.||:|||:|.|.|..:......||..:.:||.|..|..|..|.|.
plant   341 SFFRSDTRLRALRFLDHMLERDNMQKSEFLKALSDMWKDFDSRVLRYKVLPPLCAELRNLVMQPV 405

  Fly   376 VLPNVLLIAEMSSQREYCDHILPHLKPIFKLTDPIQILLIFMQKMDLLLKLTPAEEVKQSVLPLL 440
            :||.||.|||...:.::....||.|.|:.. |.....||:.:::.:|::..|.||.:...|||||
plant   406 ILPMVLTIAESQDKNDFELTTLPALVPVLS-TATGDTLLLLIKRAELIINKTNAEHLVSHVLPLL 469

  Fly   441 YRSLECDMPQIQDLCLAVLPTFSTLIDYNAMKNSVLPRIKKLCLQSSNVSVKVNCLISIGKLLEN 505
            .|:...:..:||:..|....:.:..:|...::.::|||:..|.|:::..:|:||.|:.:.:|::.
plant   470 LRAYNDNDVRIQEEVLKRSTSVAKQLDGQVVRQAILPRVHGLALKTTVAAVRVNALLCLAELVQT 534

  Fly   506 LDKWLVLDEILPFLQQ---IQSREP------AIIMGIIGIYKIAMTNTKLGITKDVMAHKCIPYL 561
            ||| |.:.|||..:|:   :....|      ||...|:..|.:..|:..:           :|.:
plant   535 LDK-LAVTEILQTIQRCTAVDRSAPTLMCTLAIANAILKQYGVEFTSEHV-----------LPLI 587

  Fly   562 VPLSVENGLTIAQFNTIISLIKEMMGRVEQEQREKLQQLSTIQRDNKPKDASEILANELENSTLS 626
            :||.....|.:.||...|..:|:::.::|:::.      .|:.....|:.....:|:.|:
plant   588 IPLLTAQQLNVQQFAKYILFVKDILRKIEEKRG------VTVNDSGVPEVKPGCVADGLQ----- 641

  Fly   627 PYGSINGNKINDDMFSGFTVGQPKAAIGAAIAPAKAREQLKISHNTISAP----PAARPDILSSM 687
                          |...|....|.|..|..:||...:.  .....||||    ||..|...:|.
plant   642 --------------FQTPTKKTEKVASAAKNSPAWDEDW--ALPTKISAPRDPGPANSPQFNNST 690

  Fly   688 MQ---SNLTGLGTITVAAAPPPTTTQMPSNNGWH-SANPLVMNHQLASPQASNNNSFSLDDLDPF 748
            :|   ||.|.:.|..     |....:.|....:: :|.|  .|.:.....|....:.|.|:||||
plant   691 VQSQSSNRTSVPTTC-----PAVDLEWPPRQSFNATAQP--ANDETRINAAGTPTTPSFDELDPF 748

  Fly   749 AGGRPSVGAPKANNTNGANMYTVQQP--------------------TVNYIYPTG-YSLNSIQQH 792
            |...|...:....:....|..|.|.|                    |.|..:..| .||:|::..
plant   749 ANWPPRPNSASTASGGFHNSTTTQPPINNSGSGLRNNLTDGRQFQTTNNDFWAFGNASLSSMKSQ 813

  Fly   793 QQQQLLGKPSQAPTLQPQTQPLLPTDNQNL---------NALSQQDI 830
            |:...:    :|....|.|...:...||.:         |...|.||
plant   814 QETSGI----RASNADPLTSFGIQNQNQGMPSFGSSSYGNQKPQADI 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1951	NP_651655.1	Pkinase	31..314	CDD:278497	105/308 (34%)
		PK_SCY1_like	37..316	CDD:270913	102/305 (33%)
		HEAT repeat	396..425	CDD:293787	8/28 (29%)
		HEAT repeat	435..465	CDD:293787	9/29 (31%)
		HEAT repeat	474..501	CDD:293787	9/26 (35%)
AT1G22870	NP_173700.2	S_TKc	39..343	CDD:214567	105/308 (34%)
		PK_SCY1_like	45..345	CDD:270913	102/304 (34%)
		HEAT repeat	431..454	CDD:293787	5/23 (22%)
		HEAT repeat	465..493	CDD:293787	9/27 (33%)
		HEAT repeat	503..534	CDD:293787	10/30 (33%)
		HEAT repeat	542..570	CDD:293787	7/27 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	138	1.000	Domainoid score	I1567
eggNOG	1	0.900	-	-		E1_KOG2137
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	291	1.000	Inparanoid score	I830
OMA	1	1.010	-	-		QHG54564
OrthoDB	1	1.010	-	-		D196028at2759
OrthoFinder	1	1.000	-	-		FOG0003248
OrthoInspector	1	1.000	-	-		mtm1180
orthoMCL	1	0.900	-	-		OOG6_102086
Panther	1	1.100	-	-	O	PTHR12984
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.840