DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1951 and Scyl2

DIOPT Version :9

Sequence 1:	NP_651655.1	Gene:	CG1951 / 43423	FlyBaseID:	FBgn0039623	Length:	835	Species:	Drosophila melanogaster
Sequence 2:	XP_006241303.1	Gene:	Scyl2 / 314717	RGDID:	1305665	Length:	934	Species:	Rattus norvegicus

Alignment Length:	900	Identity:	374/900 - (41%)
Similarity:	541/900 - (60%)	Gaps:	100/900 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MINKFYSSAVQTVSTLSGVLPGNNVTREYEVLEQVCTAGVGLMWKVYNGHKKSTKQEVSVFVFEK 67
            |:||..|:..:..:.::..:.||.||||::|...:.:.|.||.||::||.||||||||:||||:|
  Rat     4 MLNKLKSTVTKVTADVTSAVMGNPVTREFDVGRHIASGGNGLAWKIFNGTKKSTKQEVAVFVFDK 68

  Fly    68 KSLERWSKDDRETMLETLRRGVQQLTKIRHPHVLTVQHPLEESRDSLAFATEPVFASLANVVG-- 130
            |.::::.|.:::.::::|:|||||||::|||.:||||||||||||.|||.|||||||||||:|
  Rat    69 KLIDKYQKFEKDQIIDSLKRGVQQLTRLRHPRLLTVQHPLEESRDCLAFCTEPVFASLANVLGNW 133

  Fly   131 DNVRS-------EKKLYDVEIRHGLLQLFDGLQFLHQDAKIVHRNISAETIVINKNRSWKLFGFD 188
            :|:.|       :.||||||.::||||:.:||.|||...|:||.|::.|.|::||:.:||:.|||
  Rat   134 ENLPSSISPDIKDYKLYDVETKYGLLQVSEGLSFLHSSVKMVHGNVTPENIILNKSGAWKIMGFD 198

  Fly   189 FCIANQPATDGTPHWPFREYTTSLHVLAQPSLEYTAPELALNSVNTPDSDLFSLGVLIFTIY-AG 252
            ||:::...::..|.:|.:|:..:|..|..|:.||.|||..|:......||::|||.:::.:: .|
  Rat   199 FCVSSSNPSEQEPKFPCKEWDPNLPSLCLPNPEYLAPEYILSVSCETASDMYSLGAVMYAVFNKG 263

  Fly   253 KPLKMFGSD--YSSFRRYANDLNQRKYPPMNAVPSELTESLKALLHPSANLRPKLHELKQIAYFQ 315
            :|:......  |.||.|..:.|::.....:.::|.|:.|.:|.||:.:..:||...::.:|.:|.
  Rat   264 RPIFEVNKQDIYKSFSRQLDQLSRLGSSSLTSIPEEVREHVKLLLNVTPTVRPDADQMTKIPFFD 328

  Fly   316 DVGVKTLSYLDSLYQWDNLQKSKFYKGLPQIIPTLPHRVNLHSILPYLVKEFVNSPMIPFVLPNV 380
            |||..||.|.|:|:|.||||||:|:||||:::|.||.||.:..|||.|..||||..|:|||||||
  Rat   329 DVGAVTLQYFDTLFQRDNLQKSQFFKGLPKVLPKLPKRVIVQRILPCLTSEFVNPDMVPFVLPNV 393

  Fly   381 LLIAEMSSQREYCDHILPHLKPIFKLTDPIQ----ILLIFMQKMDLLLKLTPAEEVKQSVLPLLY 441
            |||||..::.||...|||.|.|:||..:|||    |||||:|||||||..||.:|:|.||||::|
  Rat   394 LLIAEECTKEEYIKLILPELGPVFKQQEPIQASNMILLIFLQKMDLLLTKTPPDEIKNSVLPMVY 458

  Fly   442 RSLECDMPQIQDLCLAVLPTFSTLIDYNAMKNSVLPRIKKLCLQSSNVSVKVNCLISIGKLLENL 506
            |:||....|||:|||.::|||:.||||.:|||:::||||..|||:|:::|:||.|:.:||:||.|
  Rat   459 RALEAPSIQIQELCLNIIPTFANLIDYPSMKNALIPRIKNACLQTSSLAVRVNSLVCLGKILEYL 523

  Fly   507 DKWLVLDEILPFLQQIQSREPAIIMGIIGIYKIAMTNTKLGITKDVMAHKCIPYLVPLSVENGLT 571
            |||.|||:||||||||.|:|||::|||:||||...|:.||||||:.:|.|.:|:|:|||:||.|.
  Rat   524 DKWFVLDDILPFLQQIPSKEPAVLMGILGIYKCTFTHKKLGITKEQLAGKVLPHLIPLSIENNLN 588

  Fly   572 IAQFNTIISLIKEMMGRVEQEQREKLQQLSTIQRDNKPKDASEILANEL---ENSTLSPYGSIN- 632
            :.||::.|::||||:.|:|.|.|.||:||..:|...:..|    :.|::   |.:.::|.|:..
  Rat   589 LNQFSSFIAVIKEMLSRLESEHRTKLEQLHIMQEQQRSLD----IGNQMSTSEETKVTPSGTQQI 649

  Fly   633 ---GNKINDDMFSGFTVG---------QPKAAIGAAIAPAK---AREQ-----------LKISHN 671
               .|.|..|:.||   |         |.|...|:.....|   |:||           ||...:
  Rat   650 DKVFNNIGADLLSG---GESENREDGLQGKQKRGSLTLEEKQKLAKEQEQAQKLKSQQPLKPQVH 711

  Fly   672 TISAPPAARPDILSSMMQ--SNLTGLGTITVAAAPPPTTTQMPS------------------NNG 716
            |..||.....|:..::|:  |:||.|...|...:...|.|.:||                  .||
  Rat   712 TPIAPVKQTKDLTDTLMENMSSLTSLSVSTPKISASSTFTSVPSTGLSMMFSTPIDNTKRNLTNG 776

  Fly   717 WHSANPLVMNHQLASPQASNNNSFSLDDLDPFAGGRPSVGAPKANNTNGANMYTV-QQPTVNYIY 780
            . :||..........|...|.|.||                  ..:|.|....|: ..||::...
  Rat   777 L-NANMGFQTSGFNMPVNPNQNFFS------------------GTSTAGVTTMTLGAPPTMSNFS 822

  Fly   781 PTGYSLNSIQQHQQQQLLGKPSQAPTLQPQTQPLLPTDNQNLNALSQQDILNFLN 835
            |......|::|.||     :|.....|.....|..|  ..::|.||||....:||
  Rat   823 PLSIPPASVKQTQQ-----RPPDMSALNNLFGPQKP--KVSMNQLSQQKPNQWLN 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1951	NP_651655.1	Pkinase	31..314	CDD:278497	126/294 (43%)
		PK_SCY1_like	37..316	CDD:270913	126/290 (43%)
		HEAT repeat	396..425	CDD:293787	21/32 (66%)
		HEAT repeat	435..465	CDD:293787	17/29 (59%)
		HEAT repeat	474..501	CDD:293787	12/26 (46%)
Scyl2	XP_006241303.1	S_TKc	32..327	CDD:214567	126/294 (43%)
		PK_SCY1_like	38..329	CDD:270913	126/290 (43%)
		HEAT repeat	373..403	CDD:293787	20/29 (69%)
		HEAT repeat	413..442	CDD:293787	18/28 (64%)
		HEAT repeat	452..482	CDD:293787	17/29 (59%)
		HEAT repeat	491..518	CDD:293787	12/26 (46%)
		Forkhead_N	746..878	CDD:254796	33/150 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341522
Domainoid	1	1.000	370	1.000	Domainoid score	I877
eggNOG	1	0.900	-	-		E1_KOG2137
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13349
Inparanoid	1	1.050	643	1.000	Inparanoid score	I780
OMA	1	1.010	-	-		QHG54564
OrthoDB	1	1.010	-	-		D196028at2759
OrthoFinder	1	1.000	-	-		FOG0003248
OrthoInspector	1	1.000	-	-		oto98491
orthoMCL	1	0.900	-	-		OOG6_102086
Panther	1	1.100	-	-	LDO	PTHR12984
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5654
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770