DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1951 and Scyl2

DIOPT Version :9

Sequence 1:	NP_651655.1	Gene:	CG1951 / 43423	FlyBaseID:	FBgn0039623	Length:	835	Species:	Drosophila melanogaster
Sequence 2:	XP_011241696.1	Gene:	Scyl2 / 213326	MGIID:	1289172	Length:	934	Species:	Mus musculus

Alignment Length:	897	Identity:	375/897 - (41%)
Similarity:	543/897 - (60%)	Gaps:	94/897 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MINKFYSSAVQTVSTLSGVLPGNNVTREYEVLEQVCTAGVGLMWKVYNGHKKSTKQEVSVFVFEK 67
            |:||..|:..:..:.::..:.||.||||::|...:.:.|.||.||::||.||||||||:||||:|
Mouse     4 MLNKLKSTVTKVTADVTSAVMGNPVTREFDVGRHIASGGNGLAWKIFNGTKKSTKQEVAVFVFDK 68

  Fly    68 KSLERWSKDDRETMLETLRRGVQQLTKIRHPHVLTVQHPLEESRDSLAFATEPVFASLANVVG-- 130
            |.::::.|.:::.::::|:|||||||::|||.:||||||||||||.|||.|||||||||||:|
Mouse    69 KLIDKYQKFEKDQIIDSLKRGVQQLTRLRHPRLLTVQHPLEESRDCLAFCTEPVFASLANVLGNW 133

  Fly   131 DNVRS-------EKKLYDVEIRHGLLQLFDGLQFLHQDAKIVHRNISAETIVINKNRSWKLFGFD 188
            :|:.|       :.||||||.::||||:.:||.|||...|:||.|::.|.:::||:.:||:.|||
Mouse   134 ENLPSSISPDIKDYKLYDVETKYGLLQVSEGLSFLHSSVKMVHGNVTPENVILNKSGAWKIMGFD 198

  Fly   189 FCIANQPATDGTPHWPFREYTTSLHVLAQPSLEYTAPELALNSVNTPDSDLFSLGVLIFTIY-AG 252
            ||:::...::..|.:|.:|:..:|..|..|:.||.|||..|:......||::|||.:::.:: .|
Mouse   199 FCVSSSNPSEQEPKFPCKEWDPNLPSLCLPNPEYLAPEYILSVSCETASDMYSLGAVMYAVFNQG 263

  Fly   253 KPLKMFGSD--YSSFRRYANDLNQRKYPPMNAVPSELTESLKALLHPSANLRPKLHELKQIAYFQ 315
            :|:......  |.||.|..:.|::.....:.::|.|:.|.:|.||:.:..:||...::.:|.:|.
Mouse   264 RPIFEVNKQDIYKSFSRQLDQLSRLGSSSLTSIPEEVREHVKLLLNVTPTVRPDADQMTKIPFFD 328

  Fly   316 DVGVKTLSYLDSLYQWDNLQKSKFYKGLPQIIPTLPHRVNLHSILPYLVKEFVNSPMIPFVLPNV 380
            |||..||.|.|:|:|.||||||:|:||||:::|.||.||.:..|||.|..||||..|:|||||||
Mouse   329 DVGAVTLQYFDTLFQRDNLQKSQFFKGLPKVLPKLPKRVIVQRILPCLTSEFVNPDMVPFVLPNV 393

  Fly   381 LLIAEMSSQREYCDHILPHLKPIFKLTDPIQ----ILLIFMQKMDLLLKLTPAEEVKQSVLPLLY 441
            |||||..::.||...|||.|.|:||..:|||    |||||:|||||||..||.:|:|.||||::|
Mouse   394 LLIAEECTKEEYIKLILPELGPVFKQQEPIQASNMILLIFLQKMDLLLTKTPPDEIKNSVLPMVY 458

  Fly   442 RSLECDMPQIQDLCLAVLPTFSTLIDYNAMKNSVLPRIKKLCLQSSNVSVKVNCLISIGKLLENL 506
            |:||....|||:|||.::|||:.||||.:|||:::||||..|||:|:::|:||.|:.:||:||.|
Mouse   459 RALEAPSIQIQELCLNIIPTFANLIDYPSMKNALIPRIKNACLQTSSLAVRVNSLVCLGKILEYL 523

  Fly   507 DKWLVLDEILPFLQQIQSREPAIIMGIIGIYKIAMTNTKLGITKDVMAHKCIPYLVPLSVENGLT 571
            |||.|||:||||||||.|:|||::|||:||||...|:.||||||:.:|.|.:|:|:|||:||.|.
Mouse   524 DKWFVLDDILPFLQQIPSKEPAVLMGILGIYKCTFTHKKLGITKEQLAGKVLPHLIPLSIENNLN 588

  Fly   572 IAQFNTIISLIKEMMGRVEQEQREKLQQLSTIQRDNKPKDASEILANEL---ENSTLSPYGSIN- 632
            :.||::.|::||||:.|:|.|.|.||:||..:|...:..|    :.|::   |.:.::..||..
Mouse   589 LNQFSSFIAVIKEMLSRLESEHRTKLEQLHVMQEQQRSLD----IGNQMSTSEETKVAHSGSQQI 649

  Fly   633 ---GNKINDDMFSGFTVG------QPKAAIGAAIAPAK---AREQ-----------LKISHNTIS 674
               .|.|..|:.||....      |.|...|:.....|   |:||           ||...:|..
Mouse   650 DKVFNNIGADLLSGSESENREDGMQGKQKRGSLTLEEKQKLAKEQEQAQKLKSQQPLKPQVHTPI 714

  Fly   675 APPAARPDILSSMMQ--SNLTGLGTITVAAAPPPTTTQMPS------------------NNGWHS 719
            ||.....|:..::|:  |:||.|...|...:...|.|.:||                  .||. :
Mouse   715 APIKQTKDLTDTLMENMSSLTSLSVSTPKISASSTFTPVPSTGLGMMFSTPIDNTKRNLTNGL-N 778

  Fly   720 ANPLVMNHQLASPQASNNNSFSLDDLDPFAG-GRPSVGAPKANNTNGANMYTVQQPTVNYIYPTG 783
            ||........:.|...|.|.||....   || ...|:|||               ||::...|..
Mouse   779 ANMGFQTSGFSMPVNPNQNFFSGTGT---AGVTTMSLGAP---------------PTMSNFSPLT 825

  Fly   784 YSLNSIQQHQQQQLLGKPSQAPTLQPQTQPLLPTDNQNLNALSQQDILNFLN 835
            ....|::|.||     :|:....|.....|..|  ..::|.||||....:||
Mouse   826 IPPASVKQPQQ-----RPTDMSALNNLFGPQKP--KVSMNQLSQQKPNQWLN 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1951	NP_651655.1	Pkinase	31..314	CDD:278497	125/294 (43%)
		PK_SCY1_like	37..316	CDD:270913	125/290 (43%)
		HEAT repeat	396..425	CDD:293787	21/32 (66%)
		HEAT repeat	435..465	CDD:293787	17/29 (59%)
		HEAT repeat	474..501	CDD:293787	12/26 (46%)
Scyl2	XP_011241696.1	PK_SCY1_like	38..329	CDD:270913	125/290 (43%)
		HEAT repeat	373..403	CDD:293787	20/29 (69%)
		HEAT repeat	413..442	CDD:293787	18/28 (64%)
		HEAT repeat	452..482	CDD:293787	17/29 (59%)
		HEAT repeat	491..518	CDD:293787	12/26 (46%)
		Forkhead_N	746..884	CDD:369872	37/151 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	373	1.000	Domainoid score	I888
eggNOG	1	0.900	-	-		E1_KOG2137
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13349
Inparanoid	1	1.050	646	1.000	Inparanoid score	I796
Isobase	1	0.950	-	0	Normalized mean entropy	S3280
OMA	1	1.010	-	-		QHG54564
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003248
OrthoInspector	1	1.000	-	-		oto94996
orthoMCL	1	0.900	-	-		OOG6_102086
Panther	1	1.100	-	-	LDO	PTHR12984
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5334
SonicParanoid	1	1.000	-	-		X5654
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.810