DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1951 and AgaP_AGAP009032

DIOPT Version :9

Sequence 1:	NP_651655.1	Gene:	CG1951 / 43423	FlyBaseID:	FBgn0039623	Length:	835	Species:	Drosophila melanogaster
Sequence 2:	XP_319783.4	Gene:	AgaP_AGAP009032 / 1279990	VectorBaseID:	AGAP009032	Length:	706	Species:	Anopheles gambiae

Alignment Length:	459	Identity:	107/459 - (23%)
Similarity:	176/459 - (38%)	Gaps:	124/459 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 WKVYNGHKKSTKQEV--SVFVFEKKSL---ERWSKDDRETMLETLRRGVQQLTKIRHPHVLTVQH 105
            |.:|||...:.....  |:.:|:.::|   :.|:..:      .|.|.::.|...|||::|  ::
Mosquito    24 WSLYNGELPNANGAAPSSISIFQGETLVSGQFWTNQN------PLERAIRNLKIYRHPYIL--KY 80

  Fly   106 PLEESRDSL-AFATE---PVFASLANVVGDNVRSEKKLYDVEIRHGLLQLFDGLQFLHQDAKIVH 166
            ....|:.|| ..|||   |:...|      |:.|     ||:|..||..:...|.||.:.|.:.|
Mosquito    81 FASWSKGSLKMLATERCRPLATCL------NITS-----DVQICLGLRNVLCALIFLLEQAAVRH 134

  Fly   167 RNISAETIVINKNRSWKLFGF-------DFCIANQPATDGTPHWPFREYTTSLHVLAQPSLEYTA 224
            .:||..:|.:..:.:|:|.||       ||   ||...:.:.  |:| ||.::     .|.|.|.
Mosquito   135 LSISISSIYVTDDGAWRLAGFEHLWRTVDF---NQTLLEKSQ--PYR-YTKAI-----DSNELTG 188

  Fly   225 PELALNSVNTPDSDLFSLGVLIFTIYAGKPLKMFGSDYSSFRRYANDLNQRKYPPMNAVPSELTE 289
            ...||        :.::.||:...|...|                .|.|         :|:  .|
Mosquito   189 KGQAL--------EQYAFGVMCEEILHNK----------------TDAN---------IPA--VE 218

  Fly   290 SLKA-----LLHPSANLRPKLHELKQIAYFQDVGVKTLSYLDSLYQWDNLQKSKFYKGLPQIIPT 349
            ..||     |.|.:..:||.|..:.....|....:...|:|..|.......|.:|:..|..
Mosquito   219 DFKAYCATHLKHGNPAMRPNLSAVLLHPIFNHDFILIHSFLTELPLKGTQAKQEFFISLAD---- 279

  Fly   350 LPHRVNLHSILPYLVKEFVNSPMIP-----------FVLPNVL------LIAEMSSQREYCDHIL 397
                 .|.|..|..|.|.:.|.::.           .|.|.||      |...:.:.:.:..:||
Mosquito   280 -----RLRSFDPETVAEQMCSLLLSRIVLLDTTAQLCVTPYVLRPKSDDLSPGLFTPKIFSAYIL 339

  Fly   398 PHLKPIFKLTDPIQILLIFMQKMDLLLKLTPAEEVKQSVLPLLYRSLECDMPQIQD-------LC 455
            |.:|.:|.:.| .||.|:.::.....::....|:::..:||.|...::    ...|       ||
Mosquito   340 PKVKQVFCVQD-AQIRLMLLEYFPAYVEFFTKEDLQDHILPQLLLGIK----DTNDVLVAKTLLC 399

  Fly   456 LAVL 459
            ||.|
Mosquito   400 LADL 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1951	NP_651655.1	Pkinase	31..314	CDD:278497	70/288 (24%)
		PK_SCY1_like	37..316	CDD:270913	71/290 (24%)
		HEAT repeat	396..425	CDD:293787	9/28 (32%)
		HEAT repeat	435..465	CDD:293787	9/32 (28%)
		HEAT repeat	474..501	CDD:293787
AgaP_AGAP009032	XP_319783.4	PKc_like	24..>156	CDD:304357	41/150 (27%)
		HEAT repeat	337..367	CDD:293787	9/30 (30%)
		HEAT repeat	376..402	CDD:293787	7/29 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910