DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1951 and AgaP_AGAP002142

DIOPT Version :9

Sequence 1:	NP_651655.1	Gene:	CG1951 / 43423	FlyBaseID:	FBgn0039623	Length:	835	Species:	Drosophila melanogaster
Sequence 2:	XP_308053.4	Gene:	AgaP_AGAP002142 / 1269416	VectorBaseID:	AGAP002142	Length:	810	Species:	Anopheles gambiae

Alignment Length:	865	Identity:	336/865 - (38%)
Similarity:	501/865 - (57%)	Gaps:	88/865 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDMINKFYSSAVQTVSTLSGVLPGNNVTREYEVLEQVCTAGVGLMWKVYNGHKKSTKQEVSVFVF 65
            ||.|||.|||..|||||||.|..||.:|::|::.|.:.:||..|:||:|.|.|::||:..|:|||
Mosquito     1 MDAINKIYSSVSQTVSTLSAVFLGNPLTKDYDIAEHIGSAGTELVWKIYTGSKRTTKEVASIFVF 65

  Fly    66 EKKSLERWSKDDRETMLETLRRGVQQLTKIRHPHVLTVQHPLEESRDSLAFATEPVFASLANVVG 130
            :||.||.::||:||.:.|.:||||.||||||||.||||||.:|||||::|||||||.|||||::|
Mosquito    66 DKKQLELFTKDEREEICENIRRGVVQLTKIRHPQVLTVQHAMEESRDTIAFATEPVVASLANLLG 130

  Fly   131 DNVR-------SEKKLYDVEIRHGLLQLFDGLQFLHQDAKIVHRNISAETIVINKNRSWKLFGFD 188
            :...       :|.||.:.:.:.|:.:|..|::|||.:.::|||::..|.|::||...||||||.
Mosquito   131 NTTNVSNTGLLAEYKLSEFDTKFGIFELIKGIRFLHDEVQLVHRHLCTENIIVNKQGVWKLFGFG 195

  Fly   189 FCIANQPATDGTP--HWPFREYTTSLHVLAQPSLEYTAPELALNSVNTPDSDLFSLGVLIFTIYA 251
            ||.:.:  ..|||  :.||:.     .:|..|..::|||||.|.  ||        .:||:|||.
Mosquito   196 FCWSKR--APGTPVGNHPFKS-----RLLGNPGSKWTAPELILE--NT--------CILIYTIYT 243

  Fly   252 GK--PLKMFGSDYSSFRRYANDLNQRKYPPMNAVPSELTESLKALLHPSANLRPKLHELKQIAYF 314
            .:  |.....||...:::....|:.:..|.:..:|..|...:|.:|..:...||.|..|.||:||
Mosquito   244 RENIPSPDASSDLYGYKQSVTKLSNQGPPKLTVIPESLRSEVKKMLSVNPQARPTLQSLTQISYF 308

  Fly   315 QDVGVKTLSYLDSLYQWDNLQKSKFYKGLPQIIPTLPHRVNLHSILPYLVKEFVNSPMIPFVLPN 379
            .|..|:.|..|::|:..|||:||:|||.|..||..:||||.|:.|||.|||||||..||||||.|
Mosquito   309 CDQYVQCLDSLETLFPKDNLEKSEFYKRLATIIGDIPHRVRLYRILPLLVKEFVNCSMIPFVLTN 373

  Fly   380 VLLIAEMSSQREYCDHILPHLKPIFKLTDPIQILLIFMQKMDLLLKLTPAEEVKQSVLPLLYRSL 444
            :|.|....::.||..|:..||:|:..|.:|:||:|||.|.:|:|||:.|:||::.|||||:|::|
Mosquito   374 ILTITASCTRAEYMQHVSSHLRPVMLLDEPVQIMLIFFQNLDVLLKVCPSEEIRASVLPLVYKAL 438

  Fly   445 ECDMPQIQDLCLAVLPTFSTLIDYNAMKNSVLPRIKKLCLQSSNVSVKVNCLISIGKLLENLDKW 509
            |....|||:|||:::|:....:|...:|..::||||.||..::.|||:|.||:.:|:|...:|||
Mosquito   439 ESKSQQIQELCLSIIPSVVVHLDKATIKGGLVPRIKTLCSGTNLVSVRVKCLLCLGQLAPKIDKW 503

  Fly   510 LVLDEILPFLQQIQSREPAIIMGIIGIYKIAMTNTKLGITKDVMAHKCIPYLVPLSVENGLTIAQ 574
            :::|:|:.:|..:..||||:||.|:|:|||:.....|||.|||:|.|.:|:|.|:::.|||::.|
Mosquito   504 VMIDDIVSYLPSVNCREPAVIMAIVGVYKISFNTDGLGIPKDVLACKVLPHLFPMTIVNGLSLQQ 568

  Fly   575 FNTIISLIKEMMGRVEQEQREKL-QQLSTIQRDNKPKDASEILANELENSTLSPYGSI---NGNK 635
            ||.||:||||...::|.||.:|| .:..:|..........|...:||:.|    :||:   :||
Mosquito   569 FNAIIALIKEFTRKIEDEQGDKLGSKAGSISSSTSSSSLQEKQQSELQQS----FGSLGFGSGN- 628

  Fly   636 INDDMFSGFTVGQPKAAIGAAIAPAKAREQLKISHNTISAPPAARPDILSSMMQSNLTGLGTITV 700
               |::..| :..|.:.:....|.:.|::|.:.........| .:..:.....||||..
Mosquito   629 ---DLYGDF-MQSPASPVPKQTAQSTAQQQQQQQQRKAGGGP-MKLQLKPLQAQSNLNW------ 682

  Fly   701 AAAPPPTTTQMPSNNGWHSANPLVMNHQLASPQASNNNSFSLDDL--DPFAGGRPSVGAPKANNT 763
            :.:|..||.:..|||          .:.....|...|.|.:|.:.  .|.|...|.:.||.|..|
Mosquito   683 SVSPMATTAKENSNN----------YNLFTQQQQQQNASSTLQNKVHPPPAIAMPMMPAPAAAPT 737

  Fly   764 --NGANMYTVQQPTVNYIYPTGYSLNSIQQHQQQQLLGKPSQAPTLQP--QTQPLLPTDNQ---- 820
              ..:||:      :|....||.:        ::..|..|:.:.:..|  |.|||:||.:|
Mosquito   738 ASMASNMW------MNNNGSTGVT--------KRLELTSPTNSSSSNPYGQLQPLIPTPSQTGGK 788

  Fly   821 ------NLNALSQQDILNFL 834
                  ....||::||:.||
Mosquito   789 ASAKSATSPMLSKEDIMEFL 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1951	NP_651655.1	Pkinase	31..314	CDD:278497	120/293 (41%)
		PK_SCY1_like	37..316	CDD:270913	120/289 (42%)
		HEAT repeat	396..425	CDD:293787	13/28 (46%)
		HEAT repeat	435..465	CDD:293787	15/29 (52%)
		HEAT repeat	474..501	CDD:293787	12/26 (46%)
AgaP_AGAP002142	XP_308053.4	Pkinase	31..308	CDD:278497	120/293 (41%)
		PK_SCY1_like	37..310	CDD:270913	120/289 (42%)
		HEAT repeat	429..459	CDD:293787	15/29 (52%)
		HEAT repeat	468..495	CDD:293787	12/26 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	305	1.000	Domainoid score	I3597
eggNOG	1	0.900	-	-		E1_KOG2137
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13349
Inparanoid	1	1.050	577	1.000	Inparanoid score	I2539
OMA	1	1.010	-	-		QHG54564
OrthoDB	1	1.010	-	-		D17851at33392
OrthoFinder	1	1.000	-	-		FOG0003248
OrthoInspector	1	1.000	-	-		oto110909
Panther	1	1.100	-	-	LDO	PTHR12984
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5654
TreeFam	1	0.960	-	-
	13	12.940