DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wat and FAR1

DIOPT Version :9

Sequence 1:	NP_651652.2	Gene:	wat / 43420	FlyBaseID:	FBgn0039620	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	XP_011518702.1	Gene:	FAR1 / 84188	HGNCID:	26222	Length:	518	Species:	Homo sapiens

Alignment Length:	485	Identity:	169/485 - (34%)
Similarity:	274/485 - (56%)	Gaps:	15/485 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 FYKDKGVFLTGGTGFFGKIIIEKLLR-VTEVGQIYLLIRTKKGKDAFARIEDLFNDPVFAKMKQV 98
            :|:.|.|.|||.|||.||:::||||| ..:|..:|:|:|.|.|:....|:|::.:..:|.:::..
Human     7 YYEGKNVLLTGATGFLGKVLLEKLLRSCPKVNSVYVLVRQKAGQTPQERVEEVLSGKLFDRLRDE 71

  Fly    99 NPKYRCQITIISGDCSLPGLGISADERETIMENVNIVLHSAATVRFDEKLKMAIAINVHGTKEII 163
            ||.:|.:|..|:.:.:.|.|.:|.:::|.|:::.||:.|.||||||:|.|:.|:.:||..|:::|
Human    72 NPDFREKIIAINSELTQPKLALSEEDKEVIIDSTNIIFHCAATVRFNENLRDAVQLNVIATRQLI 136

  Fly   164 KLAKEIVNLKALVHVSTAFAHCNMRHIQERFYSGTMSGENAFKLSECLDEHTLNTLTPTIIKGYP 228
            .||:::.||:..:|||||:|:||.:||.|..|...:..:......|.:|:..:|.:||.:|...|
Human   137 LLAQQMKNLEVFMHVSTAYAYCNRKHIDEVVYPPPVDPKKLIDSLEWMDDGLVNDITPKLIGDRP 201

  Fly   229 NTYTFTKVLAENVVQQSAQNLPVTIFRPGIVITTYREPVTGWIDNMYGPCGVIVGIGSGVLRVFT 293
            |||.:||.|||.||||....|.|.|.||.||..:::||..|||||..||.|:.:..|.|:||...
Human   202 NTYIYTKALAEYVVQQEGAKLNVAIVRPSIVGASWKEPFPGWIDNFNGPSGLFIAAGKGILRTIR 266

  Fly   294 GDMDNKAHIVPVDMCVNALLASAWDIARNKYETP---PIYNYVPDAENMVTW---RRYMEDGFEY 352
            ...:..|.:||||:.||..||:||....|:|..|   .:||....:.|...|   ..::...|:.
Human   267 ASNNALADLVPVDVVVNMSLAAAWYSGVNRYMRPRNIMVYNCTTGSTNPFHWGEVEYHVISTFKR 331

  Fly   353 GCDIPMRKSIWYPRFTIVPHMWQYHILCFLYHTLPALVMDAIMVIIGKKPRMMKIYRKIHKLSNV 417
            .   |:.::...|...:..:...||....:.|..||.:.|..:.:.|:.|||||...::||....
Human   332 N---PLEQAFRRPNVNLTSNHLLYHYWIAVSHKAPAFLYDIYLRMTGRSPRMMKTITRLHKAMVF 393

  Fly   418 LKYFSSNEFRFDNDNVRKLTEKLDDRDKRLFAFDMRDLDWTNLFRVSLYGLRLYVVKDDPSNIPE 482
            |:||:||.:.::.:||..|..:|:..||:.|..|:|.|.|.........|.:.||:.::.|.:|.
Human   394 LEYFTSNSWVWNTENVNMLMNQLNPEDKKTFNIDVRQLHWAEYIENYCLGTKKYVLNEEMSGLPA 458

  Fly   483 SIKRYERLKVLHY--TTLAVFYALAAWALY 510
            :.|...:|:.:.|  .|:.|   :..|.::
Human   459 ARKHLNKLRNIRYGFNTILV---ILIWRIF 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wat	NP_651652.2	PLN02996	35..474	CDD:215538	161/445 (36%)
		FAR-N_SDR_e	39..342	CDD:187547	123/306 (40%)
		FAR_C	382..472	CDD:176924	29/89 (33%)
FAR1	XP_011518702.1	PLN02996	2..449	CDD:215538	160/444 (36%)
		FAR-N_SDR_e	11..333	CDD:187547	125/324 (39%)
		Sterile	360..450	CDD:281068	31/89 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157524
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3320
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H41718
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100550
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X145
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.650