DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wat and Far1

DIOPT Version :9

Sequence 1:	NP_651652.2	Gene:	wat / 43420	FlyBaseID:	FBgn0039620	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001272760.1	Gene:	Far1 / 67420	MGIID:	1914670	Length:	515	Species:	Mus musculus

Alignment Length:	487	Identity:	170/487 - (34%)
Similarity:	278/487 - (57%)	Gaps:	22/487 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 FYKDKGVFLTGGTGFFGKIIIEKLLR-VTEVGQIYLLIRTKKGKDAFARIEDLFNDPVFAKMKQV 98
            :|:.|.:.|||.|||.||:::||||| ...|..:|:|:|.|.|:....|:|::.:..:|.:::..
Mouse     7 YYEGKNILLTGATGFLGKVLLEKLLRSCPRVNSVYVLVRQKAGQTPQERVEEILSSKLFDRLRDE 71

  Fly    99 NPKYRCQITIISGDCSLPGLGISADERETIMENVNIVLHSAATVRFDEKLKMAIAINVHGTKEII 163
            ||.:|.:|..|:.:.:.|.|.:|.:::|.|:::.|::.|.||||||:|.|:.|:.:||..|:::|
Mouse    72 NPDFREKIIAINSELTQPKLALSEEDKEIIIDSTNVIFHCAATVRFNENLRDAVQLNVIATRQLI 136

  Fly   164 KLAKEIVNLKALVHVSTAFAHCNMRHIQERFYSGTMSGENAFKLSECLDEHTLNTLTPTIIKGYP 228
            .||:::.||:..:|||||:|:||.:||.|..|...:..:......|.:|:..:|.:||.:|...|
Mouse   137 LLAQQMKNLEVFMHVSTAYAYCNRKHIDEVVYPPPVDPKKLIDSLEWMDDGLVNDITPKLIGDRP 201

  Fly   229 NTYTFTKVLAENVVQQSAQNLPVTIFRPGIVITTYREPVTGWIDNMYGPCGVIVGIGSGVLRVFT 293
            |||.:||.|||.||||....|.|.|.||.||..:::||..|||||..||.|:.:..|.|:||...
Mouse   202 NTYIYTKALAEYVVQQEGAKLNVAIVRPSIVGASWKEPFPGWIDNFNGPSGLFIAAGKGILRTMR 266

  Fly   294 GDMDNKAHIVPVDMCVNALLASAWDIARNKYETPPIYNYVPDAENMVTWRR---YMEDGFEYGCD 355
            ...:..|.:||||:.||..||:||....|:.....:||....:.|...|..   |:...|:..
Mouse   267 ASNNALADLVPVDVVVNTSLAAAWYSGVNRPRNIMVYNCTTGSTNPFHWGEVGDYLNHSFKMN-- 329

  Fly   356 IPMRKSIWYP--RF---TIVPHMWQYHILCFLYHTLPALVMDAIMVIIGKKPRMMKIYRKIHKLS 415
             |:.:...:|  :|   .::.|.|:     .:.||:|||::|..:.:.|:||.|||...::||..
Mouse   330 -PLNQVFRHPYVKFCSNNLMLHYWK-----GVKHTVPALLLDLALRLTGQKPWMMKTITRLHKAM 388

  Fly   416 NVLKYFSSNEFRFDNDNVRKLTEKLDDRDKRLFAFDMRDLDWTNLFRVSLYGLRLYVVKDDPSNI 480
            ..|:||:||.:.::.|||..|..:|:..||:.|..|:|.|.|.........|.:.||:.::.|.:
Mouse   389 VFLEYFTSNSWVWNTDNVNMLMNQLNPEDKKTFNIDVRQLHWAEYIENYCMGTKKYVLNEEMSGL 453

  Fly   481 PESIKRYERLKVLHY--TTLAVFYALAAWALY 510
            |.:.|...:|:.:.|  .|:.|   :..|.::
Mouse   454 PAARKHLNKLRNIRYGFNTILV---ILIWRIF 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wat	NP_651652.2	PLN02996	35..474	CDD:215538	162/447 (36%)
		FAR-N_SDR_e	39..342	CDD:187547	119/303 (39%)
		FAR_C	382..472	CDD:176924	32/89 (36%)
Far1	NP_001272760.1	FAR-N_SDR_e	11..330	CDD:187547	122/321 (38%)
Far1	NP_001272760.1	Sterile	371..447	CDD:376978	28/75 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847913
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3320
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H41718
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.712175	Normalized mean entropy	S3219
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100550
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X145
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.600