DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wat and FarO

DIOPT Version :9

Sequence 1:	NP_651652.2	Gene:	wat / 43420	FlyBaseID:	FBgn0039620	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_652021.1	Gene:	FarO / 45707	FlyBaseID:	FBgn0023550	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	504	Identity:	161/504 - (31%)
Similarity:	257/504 - (50%)	Gaps:	46/504 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 MQMFYKDKGVFLTGGTGFFGKIIIEKLLRVTEVGQIYLLIRTKKGKDAFARIEDLFNDPVFAKMK 96
            |:.|::|..:|:|||:|..||.::|||||...|.:||:|:|.:|...|..|:..|....||..:.
  Fly     9 MEEFFEDSEIFVTGGSGVVGKALVEKLLRSCNVRRIYVLLRPRKQLTAEQRLVRLRQATVFHVLA 73

  Fly    97 QVNPKYRCQITIISGDCSLPGLGISADERETIMENVNIVLHSAATVRFDEKLKMAIAINVHGTKE 161
            ...|:...:|..:.||.|||||||.....:. |:.|::|.|.||||||||.|:.|:.:||.||.|
  Fly    74 VQKPEELDKIVAVPGDVSLPGLGIDPSMMQR-MKGVSLVYHCAATVRFDEPLREAVRLNVGGTLE 137

  Fly   162 IIKLAKEIVNLKALVHVSTAFAHCNMRHIQERFYSGTMSGENAFK-LSECLDEHTLNTLTPTIIK 225
            .:|.|:.:..|:|.:||||.:::..:..::.::||..|......: :.:..|:..||.||..:|.
  Fly   138 ALKFAETLPQLRAFIHVSTFYSNPYLTRVEPKYYSSPMDWRLCLRMIDDVADDGMLNALTRKLIM 202

  Fly   226 GYPNTYTFTKVLAENVVQQSAQNLPVTIFRPGIVITTYREPVTGWIDNMYGPCGVIVGIGSGVLR 290
            |:||||||||.|||::|......|||.::||.||:....:|..|:..::.|..|:...:|:|:|:
  Fly   203 GFPNTYTFTKNLAESLVNDYRHRLPVIVYRPSIVLFAVEDPSPGFSPSLMGAMGLFALVGAGILK 267

  Fly   291 VFTGDMDNKAHIVPVDMCVNALLA---SAWDIARNKYETPPI--------------YNYVPDAEN 338
            ......|.:..|.|.|:.:.::|.   ..:||.|   :.||.              :.:...||.
  Fly   268 TVYLGKDIRLDITPQDIGIKSMLCYTKMGYDIYR---QGPPADLPVFLSSSCTHVPHTFTQIAEQ 329

  Fly   339 MVT---WRRYMEDGFEYGCDIPMRKSIWYPRFTIVPHMWQYHILCFLYHTLPALVMDAIMVIIGK 400
            |.|   ||           |:...|::..|........|.|..|.|....||||::|.::.|.|:
  Fly   330 MDTLDLWR-----------DVAFEKNLMIPGCHYTDKRWAYQFLVFTKQILPALILDLLLRIFGQ 383

  Fly   401 KPRMMKIYRKIHKLSNVLKYFSSNEFRFDNDNVRKLTEKLDDRDKRLF---AFDMRDLDWTNLFR 462
            ||.:|...||.::...|::.|..|  .:|:..|..:.......:...|   ||:..|:....:..
  Fly   384 KPVLMSAVRKAYQTLEVMQPFMFN--NWDSPGVSDMETLSKHGEGSAFNFDAFNHPDIHGLVIQS 446

  Fly   463 VS--LYGLRLYVVKDDPSNIPESIKRYERLKVLHYTTLAVF--YALAAW 507
            .|  |:.:|.:::::||..:..| ||..|:||..|..|.:|  |.|..|
  Fly   447 CSNMLHSIRTHLLREDPKTLERS-KRILRIKVFLYRLLRLFLLYKLILW 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wat	NP_651652.2	PLN02996	35..474	CDD:215538	146/464 (31%)
		FAR-N_SDR_e	39..342	CDD:187547	111/323 (34%)
		FAR_C	382..472	CDD:176924	24/94 (26%)
FarO	NP_652021.1	FAR-N_SDR_e	18..328	CDD:187547	107/313 (34%)
FarO	NP_652021.1	FAR_C	379..>410	CDD:296071	10/32 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466751
Domainoid	1	1.000	159	1.000	Domainoid score	I1277
eggNOG	1	0.900	-	-		E1_COG3320
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	1	1.000	-	-		mtm964
orthoMCL	1	0.900	-	-		OOG6_100550
Panther	1	1.100	-	-	P	PTHR11011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X145
	10	9.750