DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wat and far1

DIOPT Version :9

Sequence 1:	NP_651652.2	Gene:	wat / 43420	FlyBaseID:	FBgn0039620	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	XP_005174372.1	Gene:	far1 / 406829	ZFINID:	ZDB-GENE-040426-2908	Length:	518	Species:	Danio rerio

Alignment Length:	485	Identity:	165/485 - (34%)
Similarity:	270/485 - (55%)	Gaps:	15/485 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 FYKDKGVFLTGGTGFFGKIIIEKLLR-VTEVGQIYLLIRTKKGKDAFARIEDLFNDPVFAKMKQV 98
            :|..|.|.:||.|||.||:::||||| ...|...|:|:|.|.|:...|||.|:.|..:|.::::.
Zfish     7 YYVGKNVLITGATGFMGKVLLEKLLRSCPGVKAAYVLVRPKAGQAPDARIADMINCKLFDRLRED 71

  Fly    99 NPKYRCQITIISGDCSLPGLGISADERETIMENVNIVLHSAATVRFDEKLKMAIAINVHGTKEII 163
            .|.:..:|..|:.|.:.|.|.:||:::||:...:|:|.|.|||:||:|.||.|:.:||..|::::
Zfish    72 QPDFAGKIVAINSDLTQPNLDLSAEDQETLTGCINVVFHCAATIRFNEPLKDAMQLNVLATQKMV 136

  Fly   164 KLAKEIVNLKALVHVSTAFAHCNMRHIQERFYSGTMSGENAFKLSECLDEHTLNTLTPTIIKGYP 228
            .||..:.:|:..:|||||:|:|:...|:|..|...:.........|.:|:..::.:||.::...|
Zfish   137 SLAHRMKHLEVFIHVSTAYANCDRELIEEVVYPPPVDYRKLIDTLEWMDDKLVSLMTPRLLGERP 201

  Fly   229 NTYTFTKVLAENVVQQSAQNLPVTIFRPGIVITTYREPVTGWIDNMYGPCGVIVGIGSGVLRVFT 293
            ||||:||.|||.:|||...||.:.|.||.||..:::||..|||||..||.|:.:..|.|:||...
Zfish   202 NTYTYTKALAEQLVQQECGNLNIAIIRPSIVGASWKEPFPGWIDNFNGPSGIFIAAGKGILRTMR 266

  Fly   294 GDMDNKAHIVPVDMCVNALLASAWDIARNKYETPP---IYNYVPDAENMVTW---RRYMEDGFEY 352
            ...:..|.:||||:.:|..||:||.....::..|.   :||......|...|   ..::...|:.
Zfish   267 ASNNAVADLVPVDVVINTTLAAAWYSGSQRHARPRSLLVYNCTTGGINPFHWGEVEYHVISTFKR 331

  Fly   353 GCDIPMRKSIWYPRFTIVPH--MWQYHILCFLYHTLPALVMDAIMVIIGKKPRMMKIYRKIHKLS 415
            .   |:.::...|...:..:  :.||.|.  :.|..||.:.|..:.:.|::|||||...::||..
Zfish   332 N---PLEQAFRRPNVNLTTNHLINQYWIA--VSHKAPAFLYDLFLRMSGREPRMMKTITRLHKAM 391

  Fly   416 NVLKYFSSNEFRFDNDNVRKLTEKLDDRDKRLFAFDMRDLDWTNLFRVSLYGLRLYVVKDDPSNI 480
            .||:||:|:.:.::.|||..|..::...||::|.||:|.|.|.........|.:.||:.::.|.:
Zfish   392 MVLEYFTSHSWVWNTDNVTMLMNQMGAEDKKVFNFDVRQLHWAEYMENYCMGTKKYVLNEELSGL 456

  Fly   481 PESIKRYERLKVLHYTTLAVFYALAAWALY 510
            |.:.|...:|:.:.||...|...| .|.::
Zfish   457 PAARKHLNKLRNIRYTFNTVLVVL-IWRIF 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wat	NP_651652.2	PLN02996	35..474	CDD:215538	156/447 (35%)
		FAR-N_SDR_e	39..342	CDD:187547	116/306 (38%)
		FAR_C	382..472	CDD:176924	30/89 (34%)
far1	XP_005174372.1	FAR-N_SDR_e	11..333	CDD:187547	118/324 (36%)
far1	XP_005174372.1	Sterile	360..450	CDD:308580	32/89 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593276
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100550
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X145
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.750