DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wat and CG8303

DIOPT Version :9

Sequence 1:	NP_651652.2	Gene:	wat / 43420	FlyBaseID:	FBgn0039620	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001286495.1	Gene:	CG8303 / 36858	FlyBaseID:	FBgn0034143	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	529	Identity:	159/529 - (30%)
Similarity:	251/529 - (47%)	Gaps:	43/529 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 NIMNGMKSLEDHCQLISDVKDESPMQMFYKDKGVFLTGGTGFFGKIIIEKLLRV-TEVGQIYLLI 71
            :|.||...:..| ||.:.:    .:..|:..|.:|:||||||.|.::||.||.. .::|.||:|:
  Fly    20 SIGNGKHRVNGH-QLSTSL----TIPEFFAHKNIFVTGGTGFLGTVLIEALLDTHPDIGTIYVLV 79

  Fly    72 RTKKGKDAFARIEDLFNDPVFAKMKQVNPKYRCQITIISGDCSLPGLGISADERETIMENVNIVL 136
            |.|:..|...||..|...|:|.|..:   |...::..:.|:.|.|..|...:..:.:::.||::.
  Fly    80 RGKRKFDPNERIRRLLQKPIFEKYSE---KTLSKVVPVVGELSEPNFGFGPELLQELIDRVNVIY 141

  Fly   137 HSAATVRFDEKLKMAIAINVHGTKEIIKLAKEIVNLKALVHVSTAFAHCNMRH-IQERFYSGTMS 200
            |||||::|...|:.||..|:.||...|:|||::..|.|.::.||||.:.|.|. |.|..|.....
  Fly   142 HSAATIKFSSPLRTAIRTNLTGTMRTIELAKQLKQLAAYIYCSTAFCNSNNRGLIAEEVYKSQFD 206

  Fly   201 GENAFKLSECLDEHTLNTLTPTIIKGY----PNTYTFTKVLAENVVQQSAQNLPVTIFRPGIVIT 261
            .....|::|  |:......|....|||    ||||||||.|:||::......||..|.||.||..
  Fly   207 PYEMMKMAE--DDSAWEDFTDQKCKGYIRDHPNTYTFTKNLSENLLMAEMSGLPAAIVRPSIVYG 269

  Fly   262 TYREPVTGWIDNM-YGPCGVIVGIGSGVLRVFTGDMDNKAHIVPVDMCVNALLASAWDIARNKYE 325
            |...|:.||:.|. .|..|.:.|...|:.|...|:.:....|:|.|..:|:.|...|.:...|.|
  Fly   270 TLEHPMKGWVGNANSGHLGFLAGFVKGIFRTMCGNANAVIDIIPCDYVINSSLVMGWYVGTRKLE 334

  Fly   326 TPPIYNYVPDAENMVTWRRY---MEDGFEYGCDIPMRKSIWYPRFTIVPHMWQYHILCFLYHTLP 387
            .|.|.:......|.:....:   :.|..|..   |....:|.| .|.:.:.|:|::..:|:|.||
  Fly   335 QPEIIHCTSGEVNPLNLAEFCTIINDSVERH---PPNSFVWKP-VTKLRNGWRYNLFFYLFHLLP 395

  Fly   388 ALVMDAIMVIIGKK------PR-----MMKIYRKIHKLSNVLKYFSSNEFRFDNDNVRKLTEKLD 441
            |:|.     ||.:|      |:     .|::::|..|   ...||...:||:...|..:::..:.
  Fly   396 AMVF-----IIPEKLFGIGMPQHTAYEYMRVFQKGTK---AFDYFLDKDFRYSLKNALRISALIP 452

  Fly   442 DRDKRLFAFDMRDLDWTNLFRVSLYGLRLYVVKDDPSNIPESIKRYERLKVLHYTTLAVFYALAA 506
            :.|:|.:.||....||:......|.|:|.:..|:...........::...||:|....|.:|:..
  Fly   453 ESDRRRYNFDASQCDWSEFIDRCLIGIRRFYFKESAVTTDWHRNYWKVFNVLYYAGYVVIFAVLY 517

  Fly   507 WALYALLKL 515
            :||...|.|
  Fly   518 FALTLTLGL 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wat	NP_651652.2	PLN02996	35..474	CDD:215538	143/459 (31%)
		FAR-N_SDR_e	39..342	CDD:187547	107/309 (35%)
		FAR_C	382..472	CDD:176924	27/100 (27%)
CG8303	NP_001286495.1	FAR-N_SDR_e	46..366	CDD:187547	109/327 (33%)
CG8303	NP_001286495.1	Sterile	392..485	CDD:281068	26/100 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466796
Domainoid	1	1.000	159	1.000	Domainoid score	I1277
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I1437
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	1	1.000	-	-		mtm964
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	8.000