DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wat and CG4020

DIOPT Version :9

Sequence 1:	NP_651652.2	Gene:	wat / 43420	FlyBaseID:	FBgn0039620	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001259264.1	Gene:	CG4020 / 31522	FlyBaseID:	FBgn0029821	Length:	494	Species:	Drosophila melanogaster

Alignment Length:	493	Identity:	162/493 - (32%)
Similarity:	262/493 - (53%)	Gaps:	24/493 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 YKDKGVFLTGGTGFFGKIIIEKLLR-VTEVGQIYLLIRTKKGKDAFARIEDLFNDPVFAKMKQVN 99
            ::|:.:|:||.:||.||.:|||||| ..::|:||:|:|.|||.....|::..:...::.::::..
  Fly     7 FEDQEIFVTGASGFVGKALIEKLLRSCPKLGRIYVLMRPKKGHTIEERLQLQWESRLYERLRREQ 71

  Fly   100 PKYRCQITIISGDCSLPGLGISADERETIMENVNIVLHSAATVRFDEKLKMAIAINVHGTKEIIK 164
            |..|.::..|:||....||||.:.:.|. :.|||||.||||:||||:.|..||.:|..||.|::|
  Fly    72 PNARSKLVAIAGDVEQLGLGIGSADLER-LRNVNIVYHSAASVRFDDALSTAILLNTRGTHELVK 135

  Fly   165 LAKEIVNLKALVHVSTAFAHCNMRHIQERFYSGTMSGENAFKLSECLDEHTLNTLTPTIIKGYPN 229
            ||.|...|||.|||||.:::..:..::||.|..........||:|..|...|:..........||
  Fly   136 LALEWPKLKAFVHVSTTYSNPGVLEVEERVYPPLADWRTTIKLAETYDAEILDIFNLKYGNFQPN 200

  Fly   230 TYTFTKVLAENVVQQSAQNLPVTIFRPGIVITTYREPVTGWIDNMYGPCGVIVGIGSGVLRVFTG 294
            ||||||.|||.||.:....||:.||||.||::|..|||.||.||..||.|::|..|.|:||....
  Fly   201 TYTFTKSLAEQVVNEYRDRLPIFIFRPSIVVSTIEEPVPGWADNFNGPTGLLVACGVGILRSQNC 265

  Fly   295 DMDNKAHIVPVDMCVNALLASAWDI---ARNKYETPPIY-------NYVPDAENMVTWRRYMEDG 349
            |.:..|..||.|:....|:.|.:..   ::::.:...:|       |..|     :|....::.|
  Fly   266 DPNIVADFVPADIVARTLITSVYKFMGESKSRAKDSDLYVVNCATANISP-----ITMGEVIDIG 325

  Fly   350 FEYGCDIPMRKSIWYP--RFTIVPHMWQYHILCF-LYHTLPALVMDAIMVIIGKKPRMMKIYRKI 411
            ..:....|..|::|.|  ..|..|.:   |.:.| ..|.|.|:|:|.::.:..:||.:||:.|:|
  Fly   326 KTFIRKNPFEKTLWLPGGGMTTCPVL---HFVRFCTMHLLMAIVVDTLLRLYNEKPFLMKLQRRI 387

  Fly   412 HKLSNVLKYFSSNEFRFDNDNVRKLTEKLDDRDKRLFAF-DMRDLDWTNLFRVSLYGLRLYVVKD 475
            ....:.|:.|:..|:.|.|||.|.|.:.:...:...|.| ...::::|..|:..:.|.:.:::|:
  Fly   388 FAAFSALQVFAMTEWHFQNDNFRALHDVVPANEVSNFGFMQHANINYTEFFQHGIRGAKEFLLKE 452

  Fly   476 DPSNIPESIKRYERLKVLHYTTLAVFYALAAWALYALL 513
            .|.:...:..|.:...||.:....:.|:.....::..|
  Fly   453 SPESSSAARFRVKIFYVLDFLCRGIVYSFLLRLIFRFL 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wat	NP_651652.2	PLN02996	35..474	CDD:215538	155/452 (34%)
		FAR-N_SDR_e	39..342	CDD:187547	119/313 (38%)
		FAR_C	382..472	CDD:176924	25/90 (28%)
CG4020	NP_001259264.1	FAR-N_SDR_e	12..333	CDD:187547	121/326 (37%)
CG4020	NP_001259264.1	FAR_C	359..450	CDD:176924	25/90 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466787
Domainoid	1	1.000	159	1.000	Domainoid score	I1277
eggNOG	1	0.900	-	-		E1_COG3320
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I1437
Isobase	1	0.950	-	0.712175	Normalized mean entropy	S3219
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	1	1.000	-	-		mtm964
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X145
	11	10.850