DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wat and fard-1

DIOPT Version :9

Sequence 1:	NP_651652.2	Gene:	wat / 43420	FlyBaseID:	FBgn0039620	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001370741.1	Gene:	fard-1 / 180582	WormBaseID:	WBGene00022200	Length:	536	Species:	Caenorhabditis elegans

Alignment Length:	474	Identity:	164/474 - (34%)
Similarity:	270/474 - (56%)	Gaps:	11/474 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 YKDKGVFLTGGTGFFGKIIIEKLL-RVTEVGQIYLLIRTKKGKDAFARIEDLFNDPVFAKMKQVN 99
            |....|.|||||||.||:|:|||| .:.::..|||:|||:|||:...|:..|.:||:|.:::|..
Worm     9 YAGSSVLLTGGTGFLGKVIVEKLLWTIDDIQNIYLMIRTRKGKNPQERLSGLLHDPLFNRIRQEK 73

  Fly   100 PKYRCQITIISGDCSLPGLGISADERETIMENVNIVLHSAATVRFDEKLKMAIAINVHGTKEIIK 164
            |:...::..|.||..:..||:..::...|.:|||:|:||||||:|||.|:.|:.:||.|||.||.
Worm    74 PEAFDKLKAIGGDMMVENLGMDPEDVMLIRDNVNVVIHSAATVKFDEHLRAAVTMNVIGTKRIID 138

  Fly   165 LAKEIVNLKALVHVSTAFAHCNMRHIQERFYSGTMSGENAFKLSECLDEHTLNTLTPTIIKGYPN 229
            |..:|.:||.|||||||:|:|:.....|:.|...|:.:........:|:.||..:||.|:...||
Worm   139 LCHQIKDLKVLVHVSTAYANCDRFETTEKIYKSPMAPQKLVDALSWMDDETLTKITPKILGLRPN 203

  Fly   230 TYTFTKVLAENVVQQSAQNLPVTIFRPGIVITTYREPVTGWIDNMYGPCGVIVGIGSGVLRVFTG 294
            |||.||.|||:.::..|:::||.|.||.||...::.|:.||.||:.||.|:...:|.|||....|
Worm   204 TYTLTKALAESTIETEAKDIPVIIIRPSIVGAMWQGPLPGWTDNINGPTGIFAAVGRGVLTNMCG 268

  Fly   295 DMDNKAHIVPVDMCVNALLASA-WDIARNKYETPPIYNYVPDAE-NMVTWRR---YMEDGFEYGC 354
            ..::||.|:|||:..|.::||| :..:.|..|.|.|  :....| |.:.|..   ::|..::
Worm   269 SSESKADIIPVDIVANMIIASASYRTSINTTEIPVI--HCSSGELNPLYWGHIVLFLEQFYK--- 328

  Fly   355 DIPMRKSIWYPRFTIVPHMWQYHILCFLYHTLPALVMDAIMVIIGKKPRMMKIYRKIHKLSNVLK 419
            ..||.:....|..........:.|..::.|.:||.:.|....:|||:...:|:|.|:.|:...|.
Worm   329 KYPMEQCFAVPSTYFHKSRSLFLINYYIKHHIPAAISDISARLIGKRKNNVKLYSKVWKMIETLH 393

  Fly   420 YFSSNEFRFDNDNVRKLTEKLDDRDKRLFAFDMRDLDWTNLFRVSLYGLRLYVVKDDPSNIPESI 484
            :|::..:.|:...:.:..||:...|::.:.||:|.:||.:.....:.|::.:::|::..|:..|.
Worm   394 FFTTRGWSFNARGLPEFFEKMTPADQKEYNFDVRQVDWNSYLFDYVMGIKKFLLKENLENLNRSR 458

  Fly   485 KRYERLKVLHYTTLAVFYA 503
            ....::::......|:.||
Worm   459 AHLLKMRIRRQVIAAIVYA 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wat	NP_651652.2	PLN02996	35..474	CDD:215538	158/443 (36%)
		FAR-N_SDR_e	39..342	CDD:187547	128/305 (42%)
		FAR_C	382..472	CDD:176924	23/89 (26%)
fard-1	NP_001370741.1	FAR-N_SDR_e	13..331	CDD:187547	130/322 (40%)
fard-1	NP_001370741.1	Sterile	358..448	CDD:397244	23/89 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165457
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3320
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.712175	Normalized mean entropy	S3219
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100550
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X145
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.600