DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-gamma and Kirrel3

DIOPT Version :9

Sequence 1:	NP_651649.1	Gene:	DIP-gamma / 43417	FlyBaseID:	FBgn0039617	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	XP_006510620.1	Gene:	Kirrel3 / 67703	MGIID:	1914953	Length:	803	Species:	Mus musculus

Alignment Length:	439	Identity:	94/439 - (21%)
Similarity:	160/439 - (36%)	Gaps:	112/439 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 STLFVILIMATKCGSGSTQNQHHESSSQLDPDPEFIGFINNVTYPAGREAILACSVR-----NLG 66
            ||||:                   |...::.....:....|...|.|:|..:...::     ||.
Mouse   210 STLFI-------------------SPGDVENGQSIVCRATNKAIPGGKETSVTIDIQHPPLVNLS 255

  Fly    67 KNKVGWLRASDQTVLALQGRVVT-HNARISVMHQDMHTWKLKISKLRESDRGCYMCQINTSPMKK 130
                    ...|.|  |:..:|| |.:..:......:.|..:...::|:....|...::.:...:
Mouse   256 --------VEPQPV--LEDNIVTFHCSAKANPAVTQYRWAKRGHIIKEASGELYRTTVDYTYFSE 310

  Fly   131 QVGC--------------IDVQVPPDIINEESSADLAVQEGEDATLTCKATGNPQPRVTWRREDG 181
            .|.|              :||...|.:.:|..|  |.|..|.||..:|...|||...:.|.:...
Mouse   311 PVSCEVTNALGSTNLSRTVDVYFGPRMTSEPQS--LLVDLGSDAVFSCAWIGNPSLTIVWMKRGS 373

  Fly   182 EMILIRKPGSRELMKVESYNGSSLRLLRLERRQMGAYLCIASNDVPPAV---SKRVSLSVQFAPM 243
            .::|              .|..:|.|..:.:...|.|:|.|   |.|.|   .:.|:|:|...|:
Mouse   374 GVVL--------------SNEKTLTLKSVRQEDAGKYVCRA---VVPRVGAGEREVTLTVNGPPI 421

  Fly   244 VRAPSQLLGTPLGSDVQLECQVEASPSP--VSY-WLKGARTSNGFASVSTASLESGSPGPEMLLD 305
            : :.:|......|...|::|.:.::|.|  ::: |.:..             ||||:.|
Mouse   422 I-SSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENV-------------LESGTSG------ 466

  Fly   306 GPKYGITERRDGYRGVM-LLVVRSFSPSDVGT-YHCVSTNSLGRAEGTLRL----YEIKLHPGAS 364
              :|.: |..:...||: .|.:.:...:|..| |:|.:.||.|.....:||    .|:|...|..
Mouse   467 --RYTV-ETVNTEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLE 528

  Fly   365 ASNDDHLNYIGGLEEAARNAGRSNRTTWQPLLAMLMLLWMRLSLR-TGG 412
            |.:......||    .|..||    ..:..|:|.::......|.| |||
Mouse   529 AESVPMAVIIG----VAVGAG----VAFLVLMATIVAFCCARSQRSTGG 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-gamma	NP_651649.1	IG_like	47..139	CDD:214653	19/111 (17%)
		Ig	47..129	CDD:299845	15/87 (17%)
		Ig	140..238	CDD:299845	26/100 (26%)
		IG_like	247..355	CDD:214653	26/116 (22%)
		Ig	256..351	CDD:299845	23/99 (23%)
Kirrel3	XP_006510620.1	IG_like	54..143	CDD:214653
		Ig strand A'	56..60	CDD:409353
		Ig strand B	64..71	CDD:409353
		Ig strand C	78..82	CDD:409353
		Ig strand C'	84..87	CDD:409353
		Ig strand D	97..101	CDD:409353
		Ig strand E	104..116	CDD:409353
		Ig strand G	132..143	CDD:409353
		IgI_2_KIRREL3-like	149..246	CDD:409416	9/54 (17%)
		Ig strand B	166..170	CDD:409416
		Ig strand C	180..184	CDD:409416
		Ig strand E	210..214	CDD:409416	3/3 (100%)
		Ig strand F	224..229	CDD:409416	0/4 (0%)
		Ig strand G	239..242	CDD:409416	1/2 (50%)
		Ig	<267..334	CDD:416386	10/66 (15%)
		Ig strand B	267..274	CDD:409353	3/6 (50%)
		Ig strand C	279..286	CDD:409353	1/6 (17%)
		Ig strand C'	288..291	CDD:409353	0/2 (0%)
		Ig strand D	298..302	CDD:409353	1/3 (33%)
		Ig strand E	304..310	CDD:409353	0/5 (0%)
		Ig strand G	321..334	CDD:409353	2/12 (17%)
		Ig	335..416	CDD:416386	26/99 (26%)
		Ig strand A'	343..347	CDD:409353	2/5 (40%)
		Ig strand B	350..360	CDD:409353	3/9 (33%)
		Ig strand C	365..371	CDD:409353	1/5 (20%)
		Ig strand E	381..387	CDD:409353	2/5 (40%)
		IgI_5_KIRREL3	418..515	CDD:409479	26/119 (22%)
		Ig strand B	436..440	CDD:409479	1/3 (33%)
		Ig strand C	450..454	CDD:409479	0/3 (0%)
		Ig strand E	481..485	CDD:409479	1/3 (33%)
		Ig strand F	496..501	CDD:409479	2/4 (50%)
		Ig strand G	509..512	CDD:409479	0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810