DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-gamma and DIP-delta

DIOPT Version :9

Sequence 1:	NP_651649.1	Gene:	DIP-gamma / 43417	FlyBaseID:	FBgn0039617	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	NP_001097508.2	Gene:	DIP-delta / 5740816	FlyBaseID:	FBgn0085420	Length:	469	Species:	Drosophila melanogaster

Alignment Length:	353	Identity:	139/353 - (39%)
Similarity:	200/353 - (56%)	Gaps:	33/353 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 DPEFIGFINNVTYPAGREAILACSVRNLGKNKVGWLRASDQTVLALQGRVVTHNARISVMHQDMH 102
            :|.|...|.|||...||:|.|.|.|.:||..||.|:....|.:|.:...|::...|.|:.:.| :
  Fly    43 EPRFAQPIPNVTVAVGRDANLPCVVEHLGGYKVAWIHIDRQMILTIHRHVISRIPRYSITYTD-N 106

  Fly   103 TWKLKISKLRESDRGCYMCQINTSPMKKQVGCIDVQVPPDIINEESS-ADLAVQEGEDATLTCKA 166
            ||.|.:::..:.|||.||||:||:||..|||.:.|.|||:|::.||: :.:||:|.::..:||:|
  Fly   107 TWLLHVNQAHQDDRGYYMCQVNTNPMISQVGYLQVVVPPNILDIESTPSSVAVRENQNINMTCRA 171

  Fly   167 TGNPQPRVTWRREDGEMILIRKPGSRELMKVESYNGSSLRLLRLERRQMGAYLCIASNDVPPAVS 231
            .|.|.|::.|||||||.|.:.|.     .||..|:...|.|.::.|.:||||||||:|.|||:||
  Fly   172 DGFPAPKIIWRREDGEEIAVEKK-----KKVLVYDADVLPLTKVSRNEMGAYLCIATNGVPPSVS 231

  Fly   232 KRVSLSVQFAPMVRAPSQLLGTPLGSDVQLECQVEASPSPVSYWLKGARTSNGFASVSTASLESG 296
            ||:.|.|:|:||:..|:||:|.|.|:||.::|..||.|..:.||:        :.||
  Fly   232 KRIILDVEFSPMIWVPNQLVGAPSGTDVTIDCHTEAHPKAIIYWV--------YNSV-------- 280

  Fly   297 SPGPEMLLDGPKYGITERRDGYRGVMLLVVRSFSPSDVGTYHCVSTNSLGRAEGTLRLYEIKLHP 361
                 |:|...||......:.||..|.|.:|:....|.|.|.|:|.||||..||::|:|||.| |
  Fly   281 -----MVLPSKKYKTDYTENSYRAHMKLTIRNLQYGDFGNYRCISKNSLGETEGSIRVYEIPL-P 339

  Fly   362 GASASNDDHLNYIGGLEEAARNAGRSNR 389
            ...:....|..    :|....|...|:|
  Fly   340 STPSKQVTHTT----VESRENNIIPSSR 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-gamma	NP_651649.1	IG_like	47..139	CDD:214653	38/91 (42%)
		Ig	47..129	CDD:299845	33/81 (41%)
		Ig	140..238	CDD:299845	46/98 (47%)
		IG_like	247..355	CDD:214653	37/107 (35%)
		Ig	256..351	CDD:299845	30/94 (32%)
DIP-delta	NP_001097508.2	IG	51..143	CDD:214652	38/92 (41%)
		Ig	145..238	CDD:416386	45/97 (46%)
		Ig strand A	145..149	CDD:409353	2/3 (67%)
		Ig strand A'	154..159	CDD:409353	0/4 (0%)
		Ig strand B	165..172	CDD:409353	2/6 (33%)
		Ig strand C	178..183	CDD:409353	1/4 (25%)
		Ig strand C'	185..187	CDD:409353	1/1 (100%)
		Ig strand D	195..199	CDD:409353	2/3 (67%)
		Ig strand E	203..209	CDD:409353	2/5 (40%)
		Ig strand F	216..223	CDD:409353	6/6 (100%)
		Ig strand G	230..238	CDD:409353	5/7 (71%)
		Ig	242..333	CDD:416386	38/111 (34%)
		Ig strand A'	250..253	CDD:409353	1/2 (50%)
		Ig strand B	259..266	CDD:409353	2/6 (33%)
		Ig strand C	272..277	CDD:409353	2/12 (17%)
		Ig strand C'	281..283	CDD:409353	1/1 (100%)
		Ig strand D	289..293	CDD:409353	0/3 (0%)
		Ig strand E	295..305	CDD:409353	4/9 (44%)
		Ig strand F	314..322	CDD:409353	4/7 (57%)
		Ig strand G	325..334	CDD:409353	4/8 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	40	1.000	Domainoid score	I12510
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	128	1.000	Inparanoid score	I4644
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D102261at50557
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	1	1.000	-	-		mtm8732
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
	9	8.970