DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-gamma and ush2a

DIOPT Version :9

Sequence 1:	NP_651649.1	Gene:	DIP-gamma / 43417	FlyBaseID:	FBgn0039617	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	XP_009291422.1	Gene:	ush2a / 568982	ZFINID:	ZDB-GENE-060503-794	Length:	5243	Species:	Danio rerio

Alignment Length:	456	Identity:	88/456 - (19%)
Similarity:	149/456 - (32%)	Gaps:	181/456 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 AILACSVRNLGKNKVGWLRASDQTVLALQGRVVTHNARISVMHQDMHTWKLKIS----KLRESDR 116
            ||:||:|       .|.:.:....:..|:|...|.::.|.   .|:.::.|.:|    ..:..:.
Zfish  4358 AIIACTV-------AGCVTSGPTQIRTLEGAPATVDSPIL---SDITSYSLNVSWTVPSFQNGEI 4412

  Fly   117 GCYMCQINTSPM----KKQVGCIDVQ--VPPDII-------NEESSADLAVQEGED-----ATLT 163
            ..|:.::|...:    :..|..:|:|  |...||       ...||:.:.:|..|.     ...|
Zfish  4413 VVYILKVNNDEVYRGKRLSVQVLDLQPHVSYSIILTACTNGGCTSSSPILIQTREAPPSGMPAPT 4477

  Fly   164 CKATGNPQPRVTWR--------------REDGEMILIRKPGSRELMKVESYNGSSLR------LL 208
            .|.||.....||||              |.:|.:|               |.|:..|      |.
Zfish  4478 LKVTGPESVEVTWREPVHPNGVIMGYELRRNGSLI---------------YTGTDTRYHDFTLLP 4527

  Fly   209 RLERRQMGAYLCIASND-----VPPAVSKR------------------VSLSVQFAPMVRAPSQL 250
            .:|.    :|...|:|.     .||||::.                  .|:.|::.|..|....:
Zfish  4528 SVEY----SYTITANNSEGATTSPPAVARTQPSAPSGVAPPRLQALGPFSVMVKWDPPARPNGVI 4588

  Fly   251 LG------TPLGSDV--------------------------QLECQVEASPSPVSYWLKGARTSN 283
            :.      .|..::|                          :.|.:|||..      |.|...|:
Zfish  4589 ISYSLYKRDPAENNVKRFVFASHHSAFQSRSFSLNTLKPYYRYEVRVEACS------LLGCAASD 4647

  Fly   284 GFASVSTASLES---GSPGPEMLLDGPKYGITERRDGYRGVMLLVVRSFSPSDVGTYHCVSTNSL 345
             ::|:.|  |||   |.|.|          :.|.:...:|:..:.:.|:||..
Zfish  4648 -WSSIQT--LESPPAGQPAP----------LLELQTNPKGLQTVFLLSWSPPT------------ 4687

  Fly   346 GRAEGTLRLYEI-KLH---------------PGASASNDDHLNYIGGLEE---AARNAGRSNRTT 391
             ...|.|..||: :.|               ..:::.:||.|......|.   |..:|||:. :.
Zfish  4688 -EPNGKLLHYELYRKHLSDMESRSVTTLVYSDSSTSCHDDKLQPYTAYEYQVWAVNSAGRAG-SP 4750

  Fly   392 W 392
            |
Zfish  4751 W 4751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-gamma	NP_651649.1	IG_like	47..139	CDD:214653	18/92 (20%)
		Ig	47..129	CDD:299845	15/80 (19%)
		Ig	140..238	CDD:299845	30/152 (20%)
		IG_like	247..355	CDD:214653	24/142 (17%)
		Ig	256..351	CDD:299845	21/123 (17%)
ush2a	XP_009291422.1	Laminin_G_3	160..297	CDD:290121
		Laminin_N	307..528	CDD:295486
		EGF_Lam	529..577	CDD:238012
		EGF_Lam	586..638	CDD:238012
		Laminin_EGF	653..703	CDD:278482
		Laminin_EGF	706..756	CDD:278482
		EGF_Lam	759..797	CDD:214543
		Laminin_EGF	808..857	CDD:278482
		EGF_Lam	859..912	CDD:238012
		EGF_Lam	913..963	CDD:238012
		EGF_Lam	965..1014	CDD:238012
		EGF_Lam	1015..1064	CDD:238012
		FN3	1177..1253	CDD:238020
		FN3	1264..1375	CDD:238020
		FN3	1386..1469	CDD:214495
		LamG	1537..1699	CDD:238058
		LamG	1737..1890	CDD:238058
		FN3	1981..2071	CDD:238020
		FN3	2163..2253	CDD:238020
		FN3	2258..2341	CDD:238020
		FN3	2352..2443	CDD:238020
		FN3	2447..2544	CDD:238020
		FN3	2547..2633	CDD:238020
		FN3	2635..2733	CDD:238020
		FN3	2743..2807	CDD:238020
		FN3	2830..2932	CDD:238020
		fn3	2939..3014	CDD:278470
		FN3	3032..>3099	CDD:238020
		FN3	3542..3611	CDD:238020
		FN3	3615..3701	CDD:238020
		fn3	3718..3784	CDD:278470
		FN3	3801..3887	CDD:238020
		FN3	3908..3971	CDD:238020
		FN3	3996..4086	CDD:238020
		FN3	4186..4284	CDD:238020
		fn3	4288..4366	CDD:278470	5/14 (36%)
		FN3	4382..4465	CDD:238020	15/85 (18%)
		FN3	4470..4553	CDD:238020	23/101 (23%)
		FN3	4555..4653	CDD:238020	14/104 (13%)
		FN3	4679..4753	CDD:238020	17/87 (20%)
		fn3	4760..4830	CDD:278470
		FN3	4864..4955	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900