DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-gamma and robo4

DIOPT Version :9

Sequence 1:	NP_651649.1	Gene:	DIP-gamma / 43417	FlyBaseID:	FBgn0039617	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	XP_689255.3	Gene:	robo4 / 560765	ZFINID:	ZDB-GENE-020809-1	Length:	1134	Species:	Danio rerio

Alignment Length:	413	Identity:	91/413 - (22%)
Similarity:	136/413 - (32%)	Gaps:	117/413 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 HHESSSQLDPD---PEFIGFINNVTYPAGREAILACSVRNLGKNKVGWLR-----------ASDQ 78
            |....|:|..:   |..:...::|....|..|.|:|......:..:.|||           |..|
Zfish    57 HRRKGSRLVSEINLPRIVHHPSDVVVRVGSPATLSCRAEGNPEPTIQWLRNGQPLDTDKMDAQSQ 121

  Fly    79 TVLALQGRV--------------------VTHNARISVMHQDMHTWKLKISKLRESDRGCYMCQI 123
            .::...|.:                    :.||   |:.:.......|.|:.|||
Zfish   122 PIVLPDGSLFFFSVVPGRKGQSHEAVYACIAHN---SIGNATSRNASLHIAALRE---------- 173

  Fly   124 NTSPMKKQVGCIDVQVPPDIINEESSADLAVQEGEDATLTCK-ATGNPQPRVTWRREDGEMILIR 187
                        |.:|.|        :|:.|..||.||:.|. ..|:|:|.||||: ||  |||.
Zfish   174 ------------DFRVQP--------SDVEVAIGEMATINCSPPVGHPEPNVTWRK-DG--ILIN 215

  Fly   188 KPGSRELMKVESYN--GSSLRLLRLERRQMGAYLCIASNDVPPAVSKRVSLSVQFAPMVRAPSQL 250
            ...       |.|.  ...|.:...::...|.|.|||||.:....|:...|||...|::....:.
Zfish   216 SSN-------EHYTELKGKLIIAPAQKNDSGVYSCIASNMIGVRESRAARLSVLAKPVLLRKPED 273

  Fly   251 LGTPLGSDVQLECQVEASPSPVSYWLKGARTSNGFASVSTASLESGSPGPEMLLDGPKYGITERR 315
            :...||...|..|:.:..|.|...|                   |...||   |...:|.|....
Zfish   274 VSVQLGESAQFFCEADGDPMPSIEW-------------------SREQGP---LPNGRYLINPDH 316

  Fly   316 DGYRGVMLLVVRSFSPSDVGTYHCVSTNSLGRAEGTLRLYEIKLHPGASASNDDHLNYIGGLEEA 380
            .       |.:...:..|:|.|.|...|.||.:..:.:|  :....|.:...|.|      .|.:
Zfish   317 S-------LQIHYVTAQDMGRYSCTVENKLGVSVASAQL--LVEDAGGTRLRDLH------KELS 366

  Fly   381 ARNAGRSNRTTWQPLLAMLMLLW 403
            |......|.|.......|..::|
Zfish   367 ALRVSLENVTVMSTASNMSQVMW 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-gamma	NP_651649.1	IG_like	47..139	CDD:214653	20/122 (16%)
		Ig	47..129	CDD:299845	19/112 (17%)
		Ig	140..238	CDD:299845	32/100 (32%)
		IG_like	247..355	CDD:214653	21/107 (20%)
		Ig	256..351	CDD:299845	20/94 (21%)
robo4	XP_689255.3	Ig1_Robo	70..169	CDD:143317	16/101 (16%)
		I-set	71..168	CDD:254352	16/99 (16%)
		I-set	175..261	CDD:254352	33/103 (32%)
		Ig2_Robo	177..261	CDD:143201	33/101 (33%)
		I-set	265..350	CDD:254352	23/115 (20%)
		Ig	282..350	CDD:299845	20/98 (20%)
		FN3	373..448	CDD:214495	4/17 (24%)
		FN3	472..560	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900