DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-gamma and KIRREL1

DIOPT Version :9

Sequence 1:	NP_651649.1	Gene:	DIP-gamma / 43417	FlyBaseID:	FBgn0039617	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	XP_005245362.1	Gene:	KIRREL1 / 55243	HGNCID:	15734	Length:	773	Species:	Homo sapiens

Alignment Length:	432	Identity:	91/432 - (21%)
Similarity:	147/432 - (34%)	Gaps:	113/432 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 STLFVILIMATKCGSGSTQNQHHESSSQLDPDPEFIGFINNVTYPAGREAILACSVRNLGKNKVG 71
            |.|..||.::.....|:......|.:.|              |..||:.|:|.|.:.|. ...|.
Human     3 SLLVWILTLSDTFSQGTQTRFSQEPADQ--------------TVVAGQRAVLPCVLLNY-SGIVQ 52

  Fly    72 WLRASDQTVLAL-QGRVVTHNARISVMHQDMHTWKLKISKLRESDRGCYMCQINTSPMKKQVGCI 135
            |.:  |...|.: ||.......|: |...|...:.|:|:....||...|.||...:.::.:...:
Human    53 WTK--DGLALGMGQGLKAWPRYRV-VGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKL 114

  Fly   136 DVQVPPDIINEESSADLAVQEGEDATLTCKA-TGNPQPRVTWRREDG----------EMILIRKP 189
            .|.:||:....:....:.:|.|....|||:| ...|...:.|.| ||          |::   |.
Human   115 TVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFR-DGTQQEGAVASTELL---KD 175

  Fly   190 GSRELMKVE-SYNGSSLRLLRLERRQMGAYLCIASND-VPPAVSKRVSLSVQFAPMVRAPSQLLG 252
            |.||....: ..|.:.|.:.|:       :.|.:.|: :|......:.|.|...|.|....:...
Human   176 GKRETTVSQLLINPTDLDIGRV-------FTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQT 233

  Fly   253 TPLGSDVQLECQVEASPSPVSY-WLKG--------------------------ARTSNGFASVST 290
            ...|..|...||..|:|..:.| |.||                          ....|...|.:.
Human   234 VQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNV 298

  Fly   291 ASLESGSPGPEMLLDGPKYGITE----------------------RRDGYRGVM----------- 322
            ::|.:....|.:::| ||...|:                      ::|...|..
Human   299 STLVNVHFAPRIVVD-PKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMGPRPPGSPPEAALS 362

  Fly   323 --------LLVVRSFSPSDVGTYHC-VSTNSLGRAEGTLRLY 355
                    .|:::|.:.:|.|||.| .....:|.||..:.||
Human   363 AQVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLY 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-gamma	NP_651649.1	IG_like	47..139	CDD:214653	24/92 (26%)
		Ig	47..129	CDD:299845	23/82 (28%)
		Ig	140..238	CDD:299845	25/110 (23%)
		IG_like	247..355	CDD:214653	30/176 (17%)
		Ig	256..351	CDD:299845	30/163 (18%)
KIRREL1	XP_005245362.1	I-set	22..116	CDD:254352	25/111 (23%)
		Ig	25..116	CDD:299845	25/108 (23%)
		Ig2_KIRREL3-like	138..219	CDD:143236	21/91 (23%)
		I-set	223..304	CDD:254352	15/80 (19%)
		Ig_2	227..305	CDD:290606	13/77 (17%)
		Ig_2	311..405	CDD:290606	18/95 (19%)
		IG_like	314..405	CDD:214653	17/91 (19%)
		Ig5_KIRREL3	407..504	CDD:143306
		IG_like	416..504	CDD:214653
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810