DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-gamma and NCAM2

DIOPT Version :9

Sequence 1:	NP_651649.1	Gene:	DIP-gamma / 43417	FlyBaseID:	FBgn0039617	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	XP_011527877.1	Gene:	NCAM2 / 4685	HGNCID:	7657	Length:	874	Species:	Homo sapiens

Alignment Length:	323	Identity:	73/323 - (22%)
Similarity:	135/323 - (41%)	Gaps:	50/323 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 NVTYPAGREAILACSVRNLGKNKVGWLRASDQTVLALQGRVVTHNARISVMHQDMHTWKLKISKL 111
            |.|...|.|...:|......:..:.|.|         .|:::..|.:..:...:.   :|.:..:
Human   244 NATAERGEEMTFSCRASGSPEPAISWFR---------NGKLIEENEKYILKGSNT---ELTVRNI 296

  Fly   112 RESDRGCYMCQ-INTSPMKKQVGCIDVQVPPDIINEESSADLAVQEGEDATLTCKATGNPQPRVT 175
            ..||.|.|:|: .|.:...::...:.|.|.|.||..::.   ...|....||.|.|.|.|.|.:|
Human   297 INSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNE---TTYENGQVTLVCDAEGEPIPEIT 358

  Fly   176 WRRE-DGEMILIRKPGSREL---MKVESYNG-SSLRLLRLERRQMGAYLCIASNDVPPAVSKRVS 235
            |:|. ||   .....|.:.|   ::|:..:| |||.:..::....|.|.|.|::.: ....|.:.
Human   359 WKRAVDG---FTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRI-GGHQKSMY 419

  Fly   236 LSVQFAPMVRAPSQLLGTPLGSDVQLECQVEASPSPVSYWLKGARTSNGFASVSTASLESGSPGP 300
            |.:::||...:...:..:..|:.:.:.|.|:::|....:|   .|......:.:|.:|::.|.|.
Human   420 LDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHW---RRDKLVLPAKNTTNLKTYSTGR 481

  Fly   301 EMLLDGPKYGITERRDGYRGVMLLVVRSFSPSDVGTYHCVSTNSLGR--AEGTLRLYEIKLHP 361
            :|:|:                    :...|.:|.|.|:|.:||.:|.  .|..|.|.::...|
Human   482 KMILE--------------------IAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSP 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-gamma	NP_651649.1	IG_like	47..139	CDD:214653	17/92 (18%)
		Ig	47..129	CDD:299845	16/82 (20%)
		Ig	140..238	CDD:299845	29/102 (28%)
		IG_like	247..355	CDD:214653	22/109 (20%)
		Ig	256..351	CDD:299845	21/96 (22%)
NCAM2	XP_011527877.1	Ig1_NCAM-2	46..137	CDD:143274
		I-set	47..136	CDD:254352
		I-set	142..218	CDD:254352
		IGc2	153..214	CDD:197706
		Ig	233..326	CDD:299845	17/93 (18%)
		I-set	240..323	CDD:254352	16/90 (18%)
		Ig5_NCAM-2	325..422	CDD:143278	30/103 (29%)
		IG_like	333..420	CDD:214653	25/93 (27%)
		IG_like	438..515	CDD:214653	21/99 (21%)
		IGc2	439..507	CDD:197706	19/90 (21%)
		FN3	521..613	CDD:238020	1/4 (25%)
		fn3	619..703	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910