DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-gamma and robo2

DIOPT Version :9

Sequence 1:	NP_651649.1	Gene:	DIP-gamma / 43417	FlyBaseID:	FBgn0039617	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	NP_001259868.1	Gene:	robo2 / 44522	FlyBaseID:	FBgn0002543	Length:	1519	Species:	Drosophila melanogaster

Alignment Length:	421	Identity:	100/421 - (23%)
Similarity:	144/421 - (34%)	Gaps:	133/421 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 NVTYPAGREAILACSV-RNLGKNKVGWLRASDQTVLALQGRVVTHNARISVMHQDMHTWKLKISK 110
            |.....|..|::.|.. |...:.::.| |.:.|| |.|.|     |.||.::...    .|.|.:
  Fly   197 NTRVAQGEVALMECGAPRGSPEPQISW-RKNGQT-LNLVG-----NKRIRIVDGG----NLAIQE 250

  Fly   111 LRESDRGCYMCQINTSPMKKQVGC-------IDVQVPPDIINEESSADLAVQEGEDATLTCKATG 168
            .|:||.|.|.|.:     |..||.       :.|.|.|.:|....:....|  |......|:..|
  Fly   251 ARQSDDGRYQCVV-----KNVVGTRESATAFLKVHVRPFLIRGPQNQTAVV--GSSVVFQCRIGG 308

  Fly   169 NPQPRVTWRREDGEMILIRKPGSRELMKVESYNGSSLRLLRLERRQMGAYLCIASNDVPPAVSKR 233
            :|.|.|.|||       ....|:..|.:|......||:|..:....||.|.|.|.|.|....:..
  Fly   309 DPLPDVLWRR-------TASGGNMPLRRVHVLEDRSLKLDDVTLEDMGEYTCEADNAVGGITATG 366

  Fly   234 VSLSVQFAP--MVRAPSQLLGTPLGSDVQLECQVEASPSPVSYW---------LKGARTS----- 282
            : |:|...|  ::|..:||:  .:|.:|..|||....|.|..||         |.|.|..
  Fly   367 I-LTVHAPPKFVIRPKNQLV--EIGDEVLFECQANGHPRPTLYWSVEGNSSLLLPGYRDGRMEVT 428

  Fly   283 ----------------------------NGFASVSTASLES------------------------ 295
                                        |...|||:.::.|
  Fly   429 LTPEGRSVLSIARFAREDSGKVVTCNALNAVGSVSSRTVVSVDTQFELPPPIIEQGPVNQTLPVK 493

  Fly   296 ----------GSPGPEM--LLDGPKYGIT--ERRDGYRGVMLLVVRSFSPSDVGTYHCVSTNSLG 346
                      |:|.|::  .|||....:.  |||:......|.:.......|.|.|.||::|..|
  Fly   494 SIVVLPCRTLGTPVPQVSWYLDGIPIDVQEHERRNLSDAGALTISDLQRHEDEGLYTCVASNRNG 558

  Fly   347 RA--EGTLRL-------------YEIKLHPG 362
            ::  .|.|||             .|:..:||
  Fly   559 KSSWSGYLRLDTPTNPNIKFFRAPELSTYPG 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-gamma	NP_651649.1	IG_like	47..139	CDD:214653	27/99 (27%)
		Ig	47..129	CDD:299845	23/82 (28%)
		Ig	140..238	CDD:299845	26/97 (27%)
		IG_like	247..355	CDD:214653	40/202 (20%)
		Ig	256..351	CDD:299845	34/176 (19%)
robo2	NP_001259868.1	Ig1_Robo	90..185	CDD:143317
		I-set	91..184	CDD:254352
		I-set	190..279	CDD:254352	26/97 (27%)
		Ig2_Robo	193..279	CDD:143201	26/97 (27%)
		I-set	283..370	CDD:254352	26/96 (27%)
		Ig	300..370	CDD:299845	22/77 (29%)
		Ig	388..>457	CDD:299845	12/68 (18%)
		I-set	479..561	CDD:254352	17/81 (21%)
		Ig	496..561	CDD:143165	17/64 (27%)
		FN3	588..681	CDD:238020	2/2 (100%)
		FN3	<817..856	CDD:238020
		fn3	864..952	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010