DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-gamma and Dscam3

DIOPT Version :9

Sequence 1:	NP_651649.1	Gene:	DIP-gamma / 43417	FlyBaseID:	FBgn0039617	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster

Alignment Length:	388	Identity:	85/388 - (21%)
Similarity:	145/388 - (37%)	Gaps:	89/388 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 KC-GSGSTQNQHHESSSQLDP-DPEFIGFINNVTYPAGREAILACSVRNLGKNKVGWLRASDQTV 80
            || .|.|..:..|  |::|:. .|.::..|..:...||.:.|:.|........::.|.:|..:
  Fly   518 KCVASNSMGSVQH--SARLNVYGPPYVRAIGPIKAVAGEDIIVHCPFAGYPVEQIRWEKAHQE-- 578

  Fly    81 LALQGRVVTHNARISVMHQDMHT----WKLKISKLRES-DRGCYMCQINTSPMKKQVG------- 133
                  :.|.|      |.::.:    .:|.|..:... |:|.|.|.:     :.:.|
  Fly   579 ------LTTSN------HYELASVADGGQLVIKNVEPGRDQGIYTCIV-----RSRAGEEARRDM 626

  Fly   134 CIDVQVPPDIINEESSADLAVQEGEDATLTCKATGNPQP-RVTWRREDGEMILIRKPGSRELMKV 197
            .::|..||.|  |.......:|||..|.:||..:....| ..:|:::|..:     |.|.::.:.
  Fly   627 QLNVNSPPVI--EPFKFPKNLQEGGRAQITCAVSSGDMPIYFSWKKDDSSI-----PSSLQITEK 684

  Fly   198 ESYNGSSLRLLRLERRQMGAYLCIASNDVPPAVSKRVSLSVQFAPMVRAPSQLLGTPLGSDVQLE 262
            :....|.|....:..|..|.|.|.||| ....|:....|.|:.||..|.........||:.:.:.
  Fly   685 KEEFYSLLVFKDISARHSGKYTCYASN-AAAKVNYTAELQVRVAPRWRYEPMDTAIMLGNTISIN 748

  Fly   263 CQVEASPSPVSYWLKGARTSNGFASVSTASLESGSPGPEMLLDGPKYGITERRDGYRGVMLLVVR 327
            |:.|..|.|...|.||  ...|.......|:.:.|                          |::.
  Fly   749 CEAEGYPIPTITWFKG--QGKGSKDFKPLSMRNHS--------------------------LLLN 785

  Fly   328 SFSPSDVGTYHCVSTNSLGRA-EGTLRLYEIKLHPGASASNDDHLNYIGGLEEAARN-AGRSN 388
            ..:.:|.|.|.|.:||.:|.. :.|:|:               ::|.....|::||| :.|.|
  Fly   786 LATDNDEGYYMCQATNEIGAGLKKTIRI---------------NVNEPARFEQSARNISSRRN 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-gamma	NP_651649.1	IG_like	47..139	CDD:214653	17/103 (17%)
		Ig	47..129	CDD:299845	15/86 (17%)
		Ig	140..238	CDD:299845	26/98 (27%)
		IG_like	247..355	CDD:214653	22/108 (20%)
		Ig	256..351	CDD:299845	19/95 (20%)
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352
		Ig	264..334	CDD:143165
		I-set	345..433	CDD:254352
		Ig	358..431	CDD:143165
		Ig	456..533	CDD:143165	6/16 (38%)
		IGc2	553..619	CDD:197706	14/84 (17%)
		I-set	634..724	CDD:254352	25/97 (26%)
		ig	645..712	CDD:278476	20/72 (28%)
		IG_like	734..815	CDD:214653	22/123 (18%)
		Ig	745..815	CDD:299845	20/112 (18%)
		I-set	820..913	CDD:254352	6/14 (43%)
		Ig	838..920	CDD:299845
		FN3	917..1033	CDD:238020
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810