DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-gamma and Sdk2

DIOPT Version :9

Sequence 1:	NP_651649.1	Gene:	DIP-gamma / 43417	FlyBaseID:	FBgn0039617	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	XP_006247755.1	Gene:	Sdk2 / 360652	RGDID:	1310397	Length:	2175	Species:	Rattus norvegicus

Alignment Length:	380	Identity:	91/380 - (23%)
Similarity:	151/380 - (39%)	Gaps:	83/380 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LQSTLFVILIMATKCG-----SGSTQNQHHESSSQL-----------DP-DPEFIGFINNVTYPA 52
            |::||.::..:|...|     :.:.:|..:::|..:           || .|..|....|.:..|
  Rat   167 LENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLAVENVGGPADPIAPTIIIPPKNTSVVA 231

  Fly    53 G-REAILAC--SVRNLGKNKVGWLRASDQTVLALQGRVVTHNARISVMHQDMHTWKLKISKLRES 114
            | .|..:.|  :.|.|.|..:.|.:  |..:|:  ..:..:|.|:::.:..:            |
  Rat   232 GTSEVTMECVANARPLIKLHIVWKK--DGALLS--NGISDYNRRLTITNPMV------------S 280

  Fly   115 DRGCYMCQI-----NTSPMKKQVGCIDVQVPPDIINEESSADLAVQEGEDATLTCKATGNPQPRV 174
            |.|.|.|:.     :.:|:.:. ..:.|..||..:.|......|..| :...:.|:|.|.|.|.:
  Rat   281 DAGYYECEAMLRSSSVAPVTRG-AYLSVLEPPQFVREPERHITAEME-KVVDIPCRAKGVPPPSI 343

  Fly   175 TWRREDGEMILIRKPGSRELMKVESYNGSSLRLLRLERRQMGAYLCIASNDVPPAVSKRVSLSVQ 239
            ||.: |..::.:.|     |.:.:..:...|::..|.....|...|.|.|....|.:........
  Rat   344 TWYK-DAALVEVGK-----LTRFKQRSDGGLQISGLLPDDTGMVQCFAHNAAGEAQTSTYLAVTS 402

  Fly   240 FAP-MVRAPSQLLGTPL-GSDVQLECQVEASPSPVSYWLKGARTSNGFASVSTASLESGSPGPEM 302
            .|| :.|.|  |..|.: |..|.|.|:...:|.|...|.||.|.           |.|||
  Rat   403 IAPNITRGP--LDSTVIDGMSVVLACETSGAPRPAITWQKGERI-----------LASGS----- 449

  Fly   303 LLDGPKYGITERRDGYRGVMLLVVRSFSP---SDVGTYHCVSTNSLGRAEGTLRL 354
             :..|::.:.|     .|.:|:     ||   ||.|||.|::|||.|..|.:..|
  Rat   450 -VQLPRFTLLE-----SGSLLI-----SPTHISDAGTYTCLATNSRGVDEASADL 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-gamma	NP_651649.1	IG_like	47..139	CDD:214653	20/99 (20%)
		Ig	47..129	CDD:299845	19/89 (21%)
		Ig	140..238	CDD:299845	22/97 (23%)
		IG_like	247..355	CDD:214653	35/112 (31%)
		Ig	256..351	CDD:299845	31/97 (32%)
Sdk2	XP_006247755.1	IG_like	43..112	CDD:214653
		IGc2	43..101	CDD:197706
		IG_like	123..206	CDD:214653	7/38 (18%)
		Ig	135..191	CDD:299845	5/23 (22%)
		IG_like	225..307	CDD:214653	19/98 (19%)
		IGc2	236..289	CDD:197706	14/68 (21%)
		I-set	311..400	CDD:254352	21/95 (22%)
		Ig	329..397	CDD:143165	17/73 (23%)
		I-set	405..495	CDD:254352	37/118 (31%)
		Ig	419..495	CDD:299845	32/102 (31%)
		Ig	505..589	CDD:299845
		IG_like	505..589	CDD:214653
		FN3	593..684	CDD:238020
		FN3	696..789	CDD:238020
		FN3	797..893	CDD:238020
		FN3	898..986	CDD:238020
		FN3	996..1090	CDD:238020
		FN3	1102..1197	CDD:238020
		FN3	1204..1293	CDD:238020
		FN3	1304..1397	CDD:238020
		FN3	1403..1487	CDD:238020
		FN3	1506..1619	CDD:238020
		FN3	1629..1722	CDD:238020
		FN3	1727..1808	CDD:238020
		FN3	1840..1919	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810