DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-gamma and Dscam1

DIOPT Version :9

Sequence 1:	NP_651649.1	Gene:	DIP-gamma / 43417	FlyBaseID:	FBgn0039617	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster

Alignment Length:	355	Identity:	76/355 - (21%)
Similarity:	124/355 - (34%)	Gaps:	82/355 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 SSQLDPDPEFIGFINNVTYPAGREAILACSVRNLGKNKVGWLRASDQTVLALQGRVVTHNARISV 96
            |:::||..:.:.|        ||.|:..|.........|.|::         .|:.:.|:..:
  Fly   348 SAKIDPPTQTVDF--------GRPAVFTCQYTGNPIKTVSWMK---------DGKAIGHSEPV-- 393

  Fly    97 MHQDMHTWKLKISKLRESDRGCYMCQI-------NTSPMKKQVGCIDVQVPPDIINEESSADLAV 154
                     |:|..:::.|:|.|.|.:       ..|...|..|..|..|......||:     :
  Fly   394 ---------LRIESVKKEDKGMYQCFVRNDQESAEASAELKLGGRFDPPVIRQAFQEET-----M 444

  Fly   155 QEGEDATLTCKATGNPQPRVTWRREDGEMILIRKPGSRELMKVESY---NG---SSLRLLRLERR 213
            :.|....|.|.|.|||.|.::|.. ||     :|..:.:..:|..|   ||   |.|.:..:...
  Fly   445 EPGPSVFLKCVAGGNPTPEISWEL-DG-----KKIANNDRYQVGQYVTVNGDVVSYLNITSVHAN 503

  Fly   214 QMGAYLCIASNDVPPAVSKRVSLSVQFAPMVRAPSQLLGTPLGSDVQLECQVEASPSPVSYWLKG 278
            ..|.|.|||.:.|..| .....|:|...|.:| ..:......|..:.:.|.|...|.....|.:
  Fly   504 DGGLYKCIAKSKVGVA-EHSAKLNVYGLPYIR-QMEKKAIVAGETLIVTCPVAGYPIDSIVWER- 565

  Fly   279 ARTSNGFASVSTASLESGSPGPEMLLDGPKYGITERRDGYRGVMLLVVRSFSPSDVGTYHCVSTN 343
                                      |.....|..::..:....|::......||..||.||:.|
  Fly   566 --------------------------DNRALPINRKQKVFPNGTLIIENVERNSDQATYTCVAKN 604

  Fly   344 SLG-RAEGTLRLYEIKLHPGASASNDDHLN 372
            ..| .|.|:|.:..:.|......:.:|.:|
  Fly   605 QEGYSARGSLEVQVMVLPQIVPFAYEDLIN 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-gamma	NP_651649.1	IG_like	47..139	CDD:214653	18/98 (18%)
		Ig	47..129	CDD:299845	15/88 (17%)
		Ig	140..238	CDD:299845	28/103 (27%)
		IG_like	247..355	CDD:214653	19/108 (18%)
		Ig	256..351	CDD:299845	17/95 (18%)
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653	17/99 (17%)
		IGc2	361..413	CDD:197706	14/71 (20%)
		I-set	433..527	CDD:254352	29/105 (28%)
		IGc2	446..517	CDD:197706	23/76 (30%)
		I-set	533..618	CDD:254352	20/112 (18%)
		IGc2	544..607	CDD:197706	15/89 (17%)
		Ig	641..714	CDD:143165
		IGc2	735..804	CDD:197706
		I-set	819..914	CDD:254352
		Ig	833..921	CDD:299845
		FN3	918..1011	CDD:238020
		FN3	1018..1116	CDD:238020
		FN3	1124..1217	CDD:238020
		FN3	1222..1312	CDD:238020
		Ig	1339..1406	CDD:299845
		FN3	1409..1499	CDD:238020
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900