DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-gamma and LRIT3

DIOPT Version :9

Sequence 1:	NP_651649.1	Gene:	DIP-gamma / 43417	FlyBaseID:	FBgn0039617	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	NP_940908.3	Gene:	LRIT3 / 345193	HGNCID:	24783	Length:	679	Species:	Homo sapiens

Alignment Length:	268	Identity:	61/268 - (22%)
Similarity:	89/268 - (33%)	Gaps:	52/268 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 GEDATLTCKATGNPQPRVTWRREDGEMI---LIRKPGSRELMKVESYNGSSLRLLRLERRQMGAY 218
            |.:..|.|.|||.|.|::||.|.|...:   :|::  |.|    |....|.:.|..:..:..|.|
Human   268 GSNVLLRCDATGFPTPQITWTRSDSSPVNYTVIQE--SPE----EGVRWSIMSLTGISSKDAGDY 326

  Fly   219 LCIASN--DVPPAVSKRVSLSVQFAPMVRAPSQLLGTPLGSDVQLECQVEASPSPVSYWLKGART 281
            .|.|.|  .:..||.....|.:...|:....|:..|.....|||.......|.|..|.:|    .
Human   327 KCKAKNLAGMSEAVVTVTVLGITTTPIPPDTSERTGDHPEWDVQPGSGRSTSVSSASSYL----W 387

  Fly   282 SNGFASVSTASLESGSPGPEMLLDGPKYGITERRDGYRGVMLLVVRSFSPSDVGTYHCVSTNSLG 346
            |:.|:..|:.|..:.||                    .......:..||.|.|.:...:|| |:.
Human   388 SSSFSPTSSFSASTLSP--------------------PSTASFSLSPFSSSTVSSTTTLST-SIS 431

  Fly   347 RAEGTLRLYEIKLH----------------PGASASNDDHLNYIGGLEEAARNAGRSNRTTWQPL 395
            .:.........:||                |.||.|..:.|..:........||...|.......
Human   432 ASTTMANKRSFQLHQGGKRNLKVAKNGSKLPPASTSKKEELALLDQTMLTETNAAIENLRVVSET 496

  Fly   396 LAMLMLLW 403
            ...:.|.|
Human   497 KESVTLTW 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-gamma	NP_651649.1	IG_like	47..139	CDD:214653
		Ig	47..129	CDD:299845
		Ig	140..238	CDD:299845	26/85 (31%)
		IG_like	247..355	CDD:214653	22/107 (21%)
		Ig	256..351	CDD:299845	20/94 (21%)
LRIT3	NP_940908.3	LRR 1	56..79
		leucine-rich repeat	59..82	CDD:275378
		LRR_8	61..117	CDD:290566
		LRR 2	80..103
		leucine-rich repeat	83..106	CDD:275378
		LRR 3	104..128
		LRR_8	105..165	CDD:290566
		LRR_4	105..146	CDD:289563
		leucine-rich repeat	107..130	CDD:275378
		LRR 4	129..151
		LRR_4	131..170	CDD:289563
		leucine-rich repeat	131..154	CDD:275378
		LRR 5	152..175
		leucine-rich repeat	155..168	CDD:275378
		Ig	267..345	CDD:299845	25/82 (30%)
		IG_like	267..345	CDD:214653	25/82 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	351..375		6/23 (26%)
		FN3	486..550	CDD:214495	3/19 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810