DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-gamma and Nrg

DIOPT Version :9

Sequence 1:	NP_651649.1	Gene:	DIP-gamma / 43417	FlyBaseID:	FBgn0039617	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster

Alignment Length:	409	Identity:	98/409 - (23%)
Similarity:	160/409 - (39%)	Gaps:	113/409 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SSSQLDPDPEFIGFINNVT-YPAGREAILACSVRNLGKN--KVG----------WLRASD----- 77
            ::|::..|||...:.:||| ..|..:...|||..::.::  |:|          .:.||.
  Fly   182 NNSRMTLDPEGNLWFSNVTREDASSDFYYACSATSVFRSEYKIGNKVLLDVKQMGVSASQNKHPP 246

  Fly    78 ------------------------------QTVLALQGRVVTHNARISVMHQDMHTWKLKISKLR 112
                                          |||.:..|:.:..:.||:..|   :...|.|.:..
  Fly   247 VRQYVSRRQSLALRGKRMELFCIYGGTPLPQTVWSKDGQRIQWSDRITQGH---YGKSLVIRQTN 308

  Fly   113 ESDRGCYMCQINTSPMKKQVGCI--DVQVPPDIINEESSADLAVQEGEDATLTCKATGNPQPRVT 175
            ..|.|.|.|.::......|...|  :|...|....|...|..|  |.|:....|:|.|.|:|:::
  Fly   309 FDDAGTYTCDVSNGVGNAQSFSIILNVNSVPYFTKEPEIATAA--EDEEVVFECRAAGVPEPKIS 371

  Fly   176 WRREDGEMILIRKPGSRELMKVESYNGSSLRLLRLERRQMGAYLCIASNDVPPAVSKRVSLSVQF 240
            | ..:|:.|....|..|     .:...:::|::.|.:...|.|.|.|:|.: ..|.|.|.|:||.
  Fly   372 W-IHNGKPIEQSTPNPR-----RTVTDNTIRIINLVKGDTGNYGCNATNSL-GYVYKDVYLNVQA 429

  Fly   241 AP--MVRAPSQLLGTPLGSDVQLECQVEASPSPVSYWLKGARTSNGFASVSTASLESGSPGPEML 303
            .|  :..||: .:.|..|.:|.::|:|..||.|:..||   |.||                   .
  Fly   430 EPPTISEAPA-AVSTVDGRNVTIKCRVNGSPKPLVKWL---RASN-------------------W 471

  Fly   304 LDGPKYGITERRDGYRGVMLLVVRSFSPSDVGTYHCVSTNSLG--RAEGTL------------RL 354
            |.|.:|.:....|       |.::..:.||.|.|.|.:.|..|  :|:|:|            :.
  Fly   472 LTGGRYNVQANGD-------LEIQDVTFSDAGKYTCYAQNKFGEIQADGSLVVKEHTRITQEPQN 529

  Fly   355 YEIKLHPGASAS---NDDH 370
            ||:.  .|.||:   |:.|
  Fly   530 YEVA--AGQSATFRCNEAH 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-gamma	NP_651649.1	IG_like	47..139	CDD:214653	27/141 (19%)
		Ig	47..129	CDD:299845	24/129 (19%)
		Ig	140..238	CDD:299845	27/97 (28%)
		IG_like	247..355	CDD:214653	29/121 (24%)
		Ig	256..351	CDD:299845	25/96 (26%)
Nrg	NP_001245581.1	Ig	55..128	CDD:299845
		IG_like	57..127	CDD:214653
		Ig	135..214	CDD:299845	10/31 (32%)
		IG_like	141..216	CDD:214653	11/33 (33%)
		ig	251..332	CDD:278476	14/83 (17%)
		I-set	339..427	CDD:254352	27/96 (28%)
		Ig	354..427	CDD:299845	22/79 (28%)
		I-set	432..517	CDD:254352	30/114 (26%)
		Ig	446..517	CDD:299845	27/99 (27%)
		I-set	522..611	CDD:254352	7/27 (26%)
		ig	525..609	CDD:278476	7/24 (29%)
		FN3	613..707	CDD:238020
		FN3	716..807	CDD:238020
		fn3	817..905	CDD:278470
		FN3	917..1004	CDD:238020
		FN3	1041..1111	CDD:238020
		Bravo_FIGEY	1155..>1221	CDD:290593
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010