DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-gamma and DIP-alpha

DIOPT Version :9

Sequence 1:	NP_651649.1	Gene:	DIP-gamma / 43417	FlyBaseID:	FBgn0039617	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	NP_001259218.1	Gene:	DIP-alpha / 31322	FlyBaseID:	FBgn0052791	Length:	554	Species:	Drosophila melanogaster

Alignment Length:	368	Identity:	161/368 - (43%)
Similarity:	229/368 - (62%)	Gaps:	38/368 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 PEFIGFINNVTYPAGREAILACSVRNLGKNKVGWLRASDQTVLALQGRVVTHNARISVMHQDMHT 103
            |||:..|:||:...||:|...|.||:||..:||||:|..:.:.|:...|:|||.|::|.|.|.:|
  Fly    42 PEFVESISNVSVAVGRDATFTCHVRHLGGYRVGWLKADTKAIQAIHENVITHNPRVTVSHLDQNT 106

  Fly   104 WKLKISKLRESDRGCYMCQINTSPMKKQVGCIDVQVPPDIINEESSADLAVQEGEDATLTCKATG 168
            |.|.|..:.|.|||.||||:||.|||.|:|.:||.:|||.|:|::|:|:.|.||....|||:|.|
  Fly   107 WNLHIKAVSEEDRGGYMCQLNTDPMKSQIGFLDVVIPPDFISEDTSSDVIVPEGSSVRLTCRARG 171

  Fly   169 NPQPRVTWRREDG-EMILIRKPGSRELMKVESYNGSSLRLLRLERRQMGAYLCIASNDVPPAVSK 232
            .|:|.|||||||| |::|....|::.|  ..|:.|..|:|.::.|.:||:|||||||.|||:|||
  Fly   172 YPEPIVTWRREDGNEIVLKDNVGTKTL--APSFRGEVLKLSKISRNEMGSYLCIASNGVPPSVSK 234

  Fly   233 RVSLSVQFAPMVRAPSQLLGTPLGSDVQLECQVEASPSPVSYWLKGARTSNGFASVSTASLESGS 297
            |:|||:.|.|:::.|:||:|.|||:|||:||.|||||..::||:|                ::|
  Fly   235 RISLSIHFHPVIQVPNQLVGAPLGTDVQIECHVEASPKSINYWIK----------------DTG- 282

  Fly   298 PGPEMLLDGPKYGITERRDG-YRGVMLLVVRSFSPSDVGTYHCVSTNSLGRAEGTLRLYEIKLHP 361
               ||::...||.:.|.... |...|.::||.|...|||:|.|::.||||..:.::|||||   |
  Fly   283 ---EMIVTSGKYHVQESSQSMYETKMSMIVRKFQKDDVGSYRCIAKNSLGEVDSSIRLYEI---P 341

  Fly   362 GASASNDDHLN------YIGGLEEAARN----AGRSNRTTWQP 394
            |.: .|.:.||      ..||..:|..|    ..:..:.|:||
  Fly   342 GPN-RNKNPLNGGGKGGGAGGSLDADANDILKQKQQVKVTYQP 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-gamma	NP_651649.1	IG_like	47..139	CDD:214653	45/91 (49%)
		Ig	47..129	CDD:299845	39/81 (48%)
		Ig	140..238	CDD:299845	52/98 (53%)
		IG_like	247..355	CDD:214653	41/108 (38%)
		Ig	256..351	CDD:299845	34/95 (36%)
DIP-alpha	NP_001259218.1	IG_like	49..129	CDD:214653	37/79 (47%)
		Ig	51..131	CDD:299845	37/79 (47%)
		I-set	144..240	CDD:254352	51/97 (53%)
		IGc2	159..228	CDD:197706	35/70 (50%)
		Ig	244..337	CDD:299845	41/112 (37%)
		I-set	244..337	CDD:254352	41/112 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	40	1.000	Domainoid score	I12510
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	128	1.000	Inparanoid score	I4644
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8732
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
	8	7.970