DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-gamma and Igsf9

DIOPT Version :9

Sequence 1:	NP_651649.1	Gene:	DIP-gamma / 43417	FlyBaseID:	FBgn0039617	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	NP_001100667.1	Gene:	Igsf9 / 304982	RGDID:	1304566	Length:	1179	Species:	Rattus norvegicus

Alignment Length:	406	Identity:	96/406 - (23%)
Similarity:	141/406 - (34%)	Gaps:	121/406 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 PEFIGFINNVTYPAGREAILACS-VRNLGK---NKVGWLRASDQTVLALQ-------------GR 86
            ||.:..:..    ||..|:|.|. :...|:   :.:.|||......:.:|             ||
  Rat    24 PEVVSVVGR----AGESAVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGR 84

  Fly    87 VVTHNARISVMHQDMHTWKLKISKLRESDRGCYMCQI----NTSPMKKQVG----CIDVQVPPDI 143
            |......           .|:|..||..|:|.|.|::    ..||.:....    .:.|..||.
  Rat    85 VRLQTGA-----------SLQIEGLRVEDQGWYECRVLFLDQHSPEQDFANGSWVHLTVNSPPQ- 137

  Fly   144 INEESSADLAVQEGEDATLTCKATGNPQPRVTWRREDGEMILIRKPGSRELMKVESYNGSSLRLL 208
            ..|.....|.|:|.|..||.|.|.|:|||.|||:....::       .:...:|:..|| :|.:.
  Rat   138 FQETPPLVLEVKELEAVTLRCVALGSPQPYVTWKFRGQDL-------GKGQGQVQVRNG-TLWIR 194

  Fly   209 RLERRQMGAYLCIASNDVPPAVSKRVSLSVQFAPMVRAPSQLLGTPLGSDVQLECQVEASPSPVS 273
            |:||...|.|.|.||: ...:|:....|.|...|::..|..........||.|.|:.||.|:.::
  Rat   195 RVERGSAGDYTCQASS-TEGSVTHTTQLLVLGPPVIVVPPNNNTVNASQDVSLACRAEAYPANLT 258

  Fly   274 Y---------------------------WLKGAR----------TSNGFASVSTAS--------- 292
            |                           ||:..:          .||||....:||
  Rat   259 YSWFQDRINVFHISRLQSRVRILVDGSLWLQATQPDDAGHYTCVPSNGFPHPPSASAYLTVLYPA 323

  Fly   293 ----------LESGSPG----------PEMLLDGPKYGITERRDGYRGVML-----LVVRSFSPS 332
                      |..|..|          |.:.:...|.|...:.|.:.|..|     ||:...:..
  Rat   324 QVTVMPPETPLPIGMRGVIRCPVRANPPLLFVTWTKDGQALQLDKFPGWSLGPEGSLVIALGNED 388

  Fly   333 DVGTYHCVSTNSLGRA 348
            .:|.|.|...||||.|
  Rat   389 ALGEYSCTPYNSLGTA 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-gamma	NP_651649.1	IG_like	47..139	CDD:214653	24/116 (21%)
		Ig	47..129	CDD:299845	23/102 (23%)
		Ig	140..238	CDD:299845	32/97 (33%)
		IG_like	247..355	CDD:214653	36/173 (21%)
		Ig	256..351	CDD:299845	35/164 (21%)
Igsf9	NP_001100667.1	IG	28..110	CDD:214652	21/96 (22%)
		Ig strand A	136..139	CDD:409353	1/3 (33%)
		IG_like	143..223	CDD:214653	29/88 (33%)
		Ig strand A'	145..148	CDD:409353	1/2 (50%)
		Ig strand B	154..161	CDD:409353	3/6 (50%)
		Ig strand C	167..172	CDD:409353	3/4 (75%)
		Ig strand C'	175..177	CDD:409353	0/1 (0%)
		Ig strand D	183..187	CDD:409353	1/3 (33%)
		Ig strand E	189..193	CDD:409353	2/4 (50%)
		Ig strand F	202..210	CDD:409353	4/7 (57%)
		Ig strand G	213..223	CDD:409353	2/9 (22%)
		Ig_3	226..305	CDD:404760	12/78 (15%)
		putative Ig strand A	226..230	CDD:409353	1/3 (33%)
		putative Ig strand A'	235..239	CDD:409353	0/3 (0%)
		putative Ig strand B	241..251	CDD:409353	4/9 (44%)
		putative Ig strand C'	267..270	CDD:409353	0/2 (0%)
		putative Ig strand D	279..282	CDD:409353	0/2 (0%)
		putative Ig strand E	284..290	CDD:409353	2/5 (40%)
		putative Ig strand F	297..305	CDD:409353	0/7 (0%)
		putative Ig strand G	310..319	CDD:409353	2/8 (25%)
		Ig	322..407	CDD:416386	19/83 (23%)
		Ig strand A'	324..328	CDD:409353	0/3 (0%)
		Ig strand B	333..347	CDD:409353	3/13 (23%)
		Ig strand C	353..359	CDD:409353	0/5 (0%)
		Ig strand C'	362..364	CDD:409353	0/1 (0%)
		Ig strand D	371..374	CDD:409353	1/2 (50%)
		Ig strand E	378..382	CDD:409353	1/3 (33%)
		Ig strand F	391..399	CDD:409353	3/7 (43%)
		Ig	418..503	CDD:416386
		Ig strand A	418..421	CDD:409353
		Ig strand A'	427..430	CDD:409353
		Ig strand B	436..443	CDD:409353
		Ig strand C	449..454	CDD:409353
		Ig strand C'	457..459	CDD:409353
		Ig strand D	462..466	CDD:409353
		Ig strand E	469..473	CDD:409353
		Ig strand F	482..490	CDD:409353
		Ig strand G	493..503	CDD:409353
		FN3	508..599	CDD:238020
		FN3	625..715	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	766..807
		PHA03247	<777..1062	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..846
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	869..895
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	942..979
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1016..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000