DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-gamma and ncam1a

DIOPT Version :9

Sequence 1:	NP_651649.1	Gene:	DIP-gamma / 43417	FlyBaseID:	FBgn0039617	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	XP_009293555.1	Gene:	ncam1a / 30447	ZFINID:	ZDB-GENE-990415-31	Length:	1010	Species:	Danio rerio

Alignment Length:	394	Identity:	92/394 - (23%)
Similarity:	147/394 - (37%)	Gaps:	94/394 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 KC--GSGSTQNQ-------HHESSSQLDPDPEFIGFINNVTYPAGREAILACSVRNLGKNKVGW- 72
            ||  .||..::|       ..:.:.|..|.|:        .:..|.:|.:.|.|.:.....:.|
Zfish    93 KCVAKSGEKESQGTIIVKIFQKLTFQYAPSPQ--------EFNEGDDADIICDVISSPPPTIIWR 149

  Fly    73 ---LRASDQTVLALQGRVVTHNARISVMHQDMHTWKLKISKLRESDRGCYMCQ---INTSPMKKQ 131
               :|...:|.:.|  :|:::|             .|:|..::::|.|.|.|:   :....:..:
Zfish   150 YKKMRIQPETDVRL--KVLSNN-------------HLQIRGIKKTDEGDYTCEGRIMARGEIDLR 199

  Fly   132 VGCIDVQVPPDIINEESSADLAVQEGEDATLTCKATGNPQPRVTWRREDGEMILIRKPGSRELMK 196
            |..:.|.|.|.|....:..:......:..||.|.|.|.|:|.|.|.|           |:.||..
Zfish   200 VIKVIVNVLPSIRTRYTELNATADINQAVTLACHADGYPEPTVKWAR-----------GNTELES 253

  Fly   197 VESY----NGSSLRLLRLERRQMGAYLCIASNDVPPAVSKRVSLSVQFAPMVRAPSQLLGTPLGS 257
            .|.|    :||.|.:..:.:...|.|.|||.|..... |:.|:|:|...|.:........:.|..
Zfish   254 DEKYSLNEDGSELTIKDVNKLDEGDYKCIARNKAGER-SEEVTLNVFVQPKITFLENQTASELEE 317

  Fly   258 DVQLECQVEASPSPVSYWLKGAR--TSNGFASVSTASLESGSPGPEMLLDGPKYGITERRDGYRG 320
            .:.|.|:....|:|...|..|.|  |.|..||.:       .|.....|||   .:..|.|.  .
Zfish   318 QITLTCEATGDPTPNIIWSFGRRVFTENEQASWT-------RPEKHKSLDG---NVVVRSDA--R 370

  Fly   321 VMLLVVRSFSPSDVGTYHCVSTNSLG--------------RAEGTLRLY-----------EIKLH 360
            |..|.::....:|.|.|.|.:.||:|              :.:|...::           |...|
Zfish   371 VSSLTLKYVQFTDAGQYLCTARNSIGQDIQSMYLEVRYAPKIQGPQAVFTWEGNPANITCEALAH 435

  Fly   361 PGAS 364
            ||||
Zfish   436 PGAS 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-gamma	NP_651649.1	IG_like	47..139	CDD:214653	18/98 (18%)
		Ig	47..129	CDD:299845	16/88 (18%)
		Ig	140..238	CDD:299845	29/101 (29%)
		IG_like	247..355	CDD:214653	28/123 (23%)
		Ig	256..351	CDD:299845	26/110 (24%)
ncam1a	XP_009293555.1	Ig	20..112	CDD:299845	5/18 (28%)
		I-set	21..111	CDD:254352	5/17 (29%)
		IG_like	121..200	CDD:214653	18/101 (18%)
		IGc2	128..189	CDD:197706	16/75 (21%)
		Ig	208..301	CDD:299845	30/104 (29%)
		IG_like	219..298	CDD:214653	27/90 (30%)
		Ig	300..406	CDD:299845	28/117 (24%)
		IG_like	308..406	CDD:214653	27/109 (25%)
		ig	413..498	CDD:278476	7/27 (26%)
		IG_like	415..498	CDD:214653	6/25 (24%)
		fn3	505..589	CDD:278470
		FN3	624..715	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810