DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-gamma and Iglon5

DIOPT Version :9

Sequence 1:	NP_651649.1	Gene:	DIP-gamma / 43417	FlyBaseID:	FBgn0039617	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	NP_001157990.1	Gene:	Iglon5 / 210094	MGIID:	2686277	Length:	336	Species:	Mus musculus

Alignment Length:	381	Identity:	107/381 - (28%)
Similarity:	153/381 - (40%)	Gaps:	74/381 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SSSQLDPDPEFIGFINNVTYPAGREAILACSVRNLGKNKVGWLRASDQTVLALQGRVVTHNARIS 95
            |...|....||....:|.|...|..|.|:|.: :....:|.||..|:  :|.......|.:.|:.
Mouse    25 SRGLLSQSLEFSSPADNYTVCEGDNATLSCFI-DEHVTRVAWLNRSN--ILYAGNDRWTSDPRVR 86

  Fly    96 VMHQDMHTWKLKISKLRESDRGCYMCQINT--SPMKKQVGCIDVQVPPDIINEESSADLAVQEGE 158
            ::......:.:.|:::...|.|.|.|...|  .|...||..| |.||..|:|  .|:.:||.||.
Mouse    87 LLINTPEEFSILITQVGLGDEGLYTCSFQTRHQPYTTQVYLI-VHVPARIVN--ISSPVAVNEGG 148

  Fly   159 DATLTCKATGNPQPRVTWRR-EDGEMILIRKPGSRELMKVESYNGSSLRLLRLERRQMGAYLCIA 222
            :..|.|.|.|.|:|.||||: .||                .:..|..|.:..::|.|.|.|.|:.
Mouse   149 NVNLLCLAVGRPEPTVTWRQLRDG----------------FTSEGEILEISDIQRGQAGEYECVT 197

  Fly   223 SNDVPPAV-SKRVSLSVQFAPMVRAPSQLLGTPLGSDVQLECQVEASPSPVSYWLKGARTSNGFA 286
            .|.|..|. |:||.::|.:.|.:...:. ..|.||....|.|:..|.|.....|.|..|.
Mouse   198 HNGVNSAPDSRRVLVTVNYPPTITDVTS-ARTALGRAALLRCEAMAVPPADFQWYKDDRL----- 256

  Fly   287 SVSTASLESGSPGPEMLLDGPKYGITERRDGYRGVMLLVVRSFSPSDVGTYHCVSTNSLGRAEGT 351
                  |.|||      .:|.|.. |||...     :|:..:.|....|.|.|.:.|.||.:..:
Mouse   257 ------LSSGS------AEGLKVQ-TERTRS-----MLLFANVSARHYGNYTCRAANRLGASSAS 303

  Fly   352 LRLYEIKLHPGASASNDDHLNYIGGLEEAA-RNAGRSNRTTWQPLLAMLMLLWMRL 406
            :||    |.||:             ||.:| |..|...      ||:.|..||.|:
Mouse   304 MRL----LRPGS-------------LENSAPRPPGPLT------LLSALSWLWWRM 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-gamma	NP_651649.1	IG_like	47..139	CDD:214653	24/93 (26%)
		Ig	47..129	CDD:299845	20/83 (24%)
		Ig	140..238	CDD:299845	33/99 (33%)
		IG_like	247..355	CDD:214653	28/107 (26%)
		Ig	256..351	CDD:299845	25/94 (27%)
Iglon5	NP_001157990.1	Ig	41..129	CDD:416386	23/91 (25%)
		Ig strand A'	41..46	CDD:409353	2/4 (50%)
		Ig strand B	48..56	CDD:409353	3/7 (43%)
		CDR1	56..60	CDD:409353	0/4 (0%)
		FR2	61..68	CDD:409353	3/6 (50%)
		Ig strand C	61..67	CDD:409353	2/5 (40%)
		CDR2	69..79	CDD:409353	2/11 (18%)
		Ig strand C'	71..74	CDD:409353	1/2 (50%)
		Ig strand C'	76..79	CDD:409353	0/2 (0%)
		FR3	80..115	CDD:409353	7/34 (21%)
		Ig strand D	84..91	CDD:409353	1/6 (17%)
		Ig strand E	94..100	CDD:409353	0/5 (0%)
		Ig strand F	107..115	CDD:409353	3/7 (43%)
		CDR3	116..120	CDD:409353	1/3 (33%)
		Ig strand G	120..129	CDD:409353	4/9 (44%)
		FR4	122..129	CDD:409353	3/7 (43%)
		Ig strand A	132..137	CDD:409353	2/4 (50%)
		Ig_3	134..199	CDD:404760	26/82 (32%)
		Ig strand A'	140..145	CDD:409353	1/4 (25%)
		Ig strand B	148..157	CDD:409353	2/8 (25%)
		Ig strand C	163..167	CDD:409353	2/3 (67%)
		Ig strand D	174..177	CDD:409353	0/2 (0%)
		Ig strand E	178..183	CDD:409353	1/4 (25%)
		Ig strand F	191..199	CDD:409353	3/7 (43%)
		Ig_3	217..295	CDD:404760	25/101 (25%)
		putative Ig strand A	218..224	CDD:409353	1/5 (20%)
		Ig strand B	234..238	CDD:409353	1/3 (33%)
		Ig strand C	247..251	CDD:409353	0/3 (0%)
		Ig strand E	274..278	CDD:409353	1/8 (13%)
		Ig strand F	288..293	CDD:409353	2/4 (50%)
		Ig strand G	301..304	CDD:409353	0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	142	1.000	Inparanoid score	I4449
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	1	1.000	-	-		mtm8732
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.870