DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-gamma and Ncam2

DIOPT Version :9

Sequence 1:	NP_651649.1	Gene:	DIP-gamma / 43417	FlyBaseID:	FBgn0039617	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	NP_001106679.1	Gene:	Ncam2 / 17968	MGIID:	97282	Length:	837	Species:	Mus musculus

Alignment Length:	359	Identity:	86/359 - (23%)
Similarity:	147/359 - (40%)	Gaps:	64/359 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 KCGSGSTQNQHHESSSQLD--PDPEFIGFINNVTYPAGREAILACSVRNLGKNKVGWLRASDQTV 80
            :|.:...:.|..|::..|:  ....|...::...:..|.:|.:.|.|.:.....|.||..:::..
Mouse    92 RCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVT 156

  Fly    81 LALQGR--VVTHNARISVMHQDMHTWKLKISKLRESDRGCYMCQINTSPMKKQVGCID------- 136
            .....|  |:.:|             .|:|..:.:||.|.|.|:......    |.||
Mouse   157 TIPDNRFAVLANN-------------NLQILNINKSDEGIYRCEGRVEAR----GEIDFRDIIVI 204

  Fly   137 VQVPPDIINEESSADLAVQEGEDATLTCKATGNPQPRVTWRREDGEMILIRKPGSRELMKVESYN 201
            |.|||.|:..:.|.:...:.||:.||||||:|:|.|.::|.| :|::|   :...:.::|
Mouse   205 VNVPPAIMMPQKSFNATAERGEEMTLTCKASGSPDPTISWFR-NGKLI---EENEKYILK----- 260

  Fly   202 GSS--LRLLRLERRQMGAYLCIASNDVPPAVSKRVSLSVQFAPMVRAPSQLLG--TPLGSDVQLE 262
            ||:  |.:..:..:..|:|:|.|:|..... .|:..|.|...|.:   .||..  |.....|.|.
Mouse   261 GSNTELTVRNIINKDGGSYVCKATNKAGED-QKQAFLQVFVQPHI---LQLKNETTSENGHVTLV 321

  Fly   263 CQVEASPSPVSYWLKGARTSNGFASVSTASLESGSPGPEMLLDGPKYGITERRDGYRGVMLLVVR 327
            |:.|..|.|...|.:         ::.......|...|:        |..|.: |..|...|.:|
Mouse   322 CEAEGEPVPEITWKR---------AIDGVMFSEGDKSPD--------GRIEVK-GQHGRSSLHIR 368

  Fly   328 SFSPSDVGTYHCVSTNSLGRAEGTLRLYEIKLHP 361
            ....||.|.|.|.:.:.:|..:.::.| :|:..|
Mouse   369 DVKLSDSGRYDCEAASRIGGHQRSMHL-DIEYAP 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-gamma	NP_651649.1	IG_like	47..139	CDD:214653	21/100 (21%)
		Ig	47..129	CDD:299845	17/83 (20%)
		Ig	140..238	CDD:299845	30/99 (30%)
		IG_like	247..355	CDD:214653	24/109 (22%)
		Ig	256..351	CDD:299845	21/94 (22%)
Ncam2	NP_001106679.1	Ig1_NCAM-2	21..112	CDD:143274	4/19 (21%)
		I-set	22..111	CDD:254352	4/18 (22%)
		I-set	117..193	CDD:254352	18/88 (20%)
		IGc2	128..189	CDD:197706	17/73 (23%)
		Ig	208..301	CDD:299845	31/102 (30%)
		I-set	215..298	CDD:254352	27/92 (29%)
		Ig	300..397	CDD:299845	26/118 (22%)
		IG_like	308..395	CDD:214653	22/104 (21%)
		IG_like	413..491	CDD:214653
		IGc2	414..482	CDD:197706
		FN3	496..588	CDD:238020
		fn3	594..678	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	764..810
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000