DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-gamma and Ncam1

DIOPT Version :9

Sequence 1:	NP_651649.1	Gene:	DIP-gamma / 43417	FlyBaseID:	FBgn0039617	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	XP_006510118.1	Gene:	Ncam1 / 17967	MGIID:	97281	Length:	1162	Species:	Mus musculus

Alignment Length:	366	Identity:	80/366 - (21%)
Similarity:	140/366 - (38%)	Gaps:	77/366 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 PDPEFIGFINNVTYPAGREAILACSVRNLGKNKVGWLRASDQTVLALQGR--VVTHNARISVMHQ 99
            |.|:        .:..|.:|::.|.|.:.....:.|.......:|....|  |:::|
Mouse   124 PTPQ--------EFKEGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNN-------- 172

  Fly   100 DMHTWKLKISKLRESDRGCYMC--------QINTSPMKKQVGCIDVQVPPDIINEESSADLAVQE 156
                 .|:|..::::|.|.|.|        :||...::     :.|.|||.:...:|..:.....
Mouse   173 -----YLQIRGIKKTDEGTYRCEGRILARGEINFKDIQ-----VIVNVPPTVQARQSIVNATANL 227

  Fly   157 GEDATLTCKATGNPQPRVTWRREDGEMILIRKPGSRELMKVESYNGSSLRLLRLERRQMGAYLCI 221
            |:..||.|.|.|.|:|.::|.: |||.|...:....:  .:.|.:.|.|.:..:::.....|:||
Mouse   228 GQSVTLVCDADGFPEPTMSWTK-DGEPIENEEEDDEK--HIFSDDSSELTIRNVDKNDEAEYVCI 289

  Fly   222 ASNDVPPAVSKRVSLSVQFAPMVRAPSQLLGTPLGSDVQLECQVEASPSPVSYWLKGARTSNGFA 286
            |.|..... ...:.|.|...|.:..........|...|.|.|:....|.|...|    |||.  .
Mouse   290 AENKAGEQ-DASIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITW----RTST--R 347

  Fly   287 SVSTASLESGS-PGPEMLLDGPKYGITERRDGYRGVMLLVVRSFSPSDVGTYHCVSTNSLG---- 346
            ::|:....|.: |..:..|||.....:..|     |..|.::|...:|.|.|.|.::|::|
Mouse   348 NISSEEKASWTRPEKQETLDGHMVVRSHAR-----VSSLTLKSIQYTDAGEYICTASNTIGQDSQ 407

  Fly   347 ----------RAEGTLRLY-----------EIKLHPGASAS 366
                      :.:|.:.:|           |:..:|.|:.|
Mouse   408 SMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATIS 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-gamma	NP_651649.1	IG_like	47..139	CDD:214653	18/101 (18%)
		Ig	47..129	CDD:299845	17/91 (19%)
		Ig	140..238	CDD:299845	25/97 (26%)
		IG_like	247..355	CDD:214653	27/122 (22%)
		Ig	256..351	CDD:299845	25/109 (23%)
Ncam1	XP_006510118.1	Ig1_NCAM-1	20..115	CDD:143273
		IG	124..190	CDD:214652	16/86 (19%)
		Ig3_NCAM-1_like	211..308	CDD:143207	26/100 (26%)
		Ig_NCAM-1	307..413	CDD:143277	27/116 (23%)
		Ig_3	417..494	CDD:372822	6/32 (19%)
		FN3	509..606	CDD:238020
		fn3	649..731	CDD:365830
		PHA03247	<905..1140	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000