DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-gamma and ncam2

DIOPT Version :9

Sequence 1:	NP_651649.1	Gene:	DIP-gamma / 43417	FlyBaseID:	FBgn0039617	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	NP_571905.1	Gene:	ncam2 / 114441	ZFINID:	ZDB-GENE-010822-1	Length:	795	Species:	Danio rerio

Alignment Length:	409	Identity:	89/409 - (21%)
Similarity:	160/409 - (39%)	Gaps:	68/409 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 KCGSGSTQNQHHESSSQLDPDPEFIGFINNVTYP----AGREAILACSVRNLGKNKVGWLRASDQ 78
            :|.:...|.:..|::..|:...:..  ..:|..|    .|..|.:.|.|.:.....|.|...:.:
Zfish    91 RCQATDAQGETQEATVVLEIYQKLT--FRDVRSPQEFRQGEVAEVVCDVTSSPVPVVSWFYNNIE 153

  Fly    79 TVLALQGRVVTHNARISVMHQDMHTWKLKISKLRESDRGCYMCQINTSPMKKQVGCID------- 136
                    :.....:..::..:    .|::.|:.::|.|.|.|:......    |.||
Zfish   154 --------ITEDTEKFELLQNN----NLQVQKVTKADEGVYRCEARVEAR----GEIDFRNIILV 202

  Fly   137 VQVPPDIINEESSADLAVQEGEDATLTCKATGNPQPRVTWRREDGEMILIRKPGSRELMKVESYN 201
            |.|||.:...:.|.:.....||..|.||:|.|:|:|.|||.|:..::    :...|.:|:.   .
Zfish   203 VNVPPVVSVPQQSFNATADYGESVTFTCRAYGSPEPDVTWHRKGVQL----QESERYVMRA---R 260

  Fly   202 GSSLRLLRLERRQMGAYLCIASNDVPPAVSKRVSLSVQFAPMVRAPSQLLGTPLGSDVQLECQVE 266
            |::|.:..:::...|:|.|.|||.. ..|...:.|.|...|.:.....:.... ||...:.|:.|
Zfish   261 GTTLTVRNIQQDDGGSYTCRASNKA-GEVEHELFLKVFVQPHITKLRNVTAVE-GSAAMISCKAE 323

  Fly   267 ASPSPVSYWLKGARTSNGFASVSTASLESGSPGPEMLLDGPKYGITERRDGYRGVMLLVVRSFSP 331
            ..|.|...|   .|.|:|.      |...|...|:        |..|.|..| |..:|.:.....
Zfish   324 GEPLPEISW---RRASDGH------SFSDGDKSPD--------GRVEVRGRY-GESMLTIVVVKL 370

  Fly   332 SDVGTYHCVSTNSLGRAEGTLRLYEIKLHPGASASNDDHLNYIGGLEEAARNAGRSNRTTWQPLL 396
            ||.|.:.|.:.:.:|..:.::.| :|:..|...|::....::.|.....:.:...:...|
Zfish   371 SDWGRFDCEALSRIGGHQKSMFL-DIEYAPKFQANHTIFFSWEGNPVNISCDVMSNPPAT----- 429

  Fly   397 AMLMLLWMR--LSLRTGGA 413
                :||.|  |::.:.||
Zfish   430 ----MLWRREKLTIPSEGA 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-gamma	NP_651649.1	IG_like	47..139	CDD:214653	18/102 (18%)
		Ig	47..129	CDD:299845	14/85 (16%)
		Ig	140..238	CDD:299845	28/97 (29%)
		IG_like	247..355	CDD:214653	24/107 (22%)
		Ig	256..351	CDD:299845	24/94 (26%)
ncam2	NP_571905.1	Ig1_NCAM-2	20..111	CDD:143274	4/19 (21%)
		I-set	21..110	CDD:254352	4/18 (22%)
		IGc2	127..187	CDD:197706	12/71 (17%)
		Ig	213..299	CDD:299845	27/93 (29%)
		I-set	213..296	CDD:254352	26/90 (29%)
		Ig	298..395	CDD:299845	26/116 (22%)
		I-set	300..393	CDD:254352	25/111 (23%)
		IG_like	411..488	CDD:214653	8/43 (19%)
		IGc2	412..480	CDD:197706	8/42 (19%)
		FN3	494..586	CDD:238020
		fn3	<616..675	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010